Institut für Pharmakologie

Publikationen (Publications)


Verma D., Wood J., Lach G., Herzog H., Sperk G. and Tasan R. (2016) Hunger Promotes Fear Extinction by Activation of an Amygdala Microcircuit. Neuropsychopharmacology 41, 431–439.


Asede D., Bosch D., Lüthi A., Ferraguti F. and Ehrlich I. (2015) Sensory Inputs to Intercalated Cells Provide Fear-Learning Modulated Inhibition to the Basolateral Amygdala. Neuron

Bazelot M., Bocchio M., Kasugai Y., Fischer D., Dodson P.D., Ferraguti F. and Capogna M. (2015) Hippocampal Theta Input to the Amygdala Shapes Feedforward Inhibition to Gate Heterosynaptic Plasticity. Neuron 87, 1290–1303.

Bienvenu T.C., Busti D., Micklem B.R., Mansouri M., Magill P.J., Ferraguti F. and Capogna M. (2015) Large intercalated neurons of amygdala relay noxious sensory information. J. Neurosci. 35, 2044–2057.

Botta P., Demmou L., Kasugai Y., Markovic M., Xu C., Fadok J.P., Lu T., Poe M.M., Xu L., Cook J.M., Rudolph U., Sah P., Ferraguti F. and Lüthi A. (2015) Regulating anxiety with extrasynaptic inhibition. Nat. Neurosci. 18, 1493–1500.

Burtscher J., Zangrandi L., Schwarzer C. and Gnaiger E. (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25, 104–112.

Drexel, M., Puhakka, N., Kirchmair, E., Hörtnagl, H., Pitkanen, A. and Sperk, G. (2015) Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury. Neuropharmacology 88, 122-133.

Jagirdar R., Drexel M., Bukovac A., Tasan R.O. and Sperk G. (2015) Expression of class II HDACs in two mouse models of temporal lobe epilepsy. J. Neurochem.

Jagirdar R., Drexel M., Kirchmair E., Tasan R.O. and Sperk G. (2015) Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy. Exp Neurol 273, 92–104.

Kapuralin K., Ćurlin M., Mitrečić D., Kosi N., Schwarzer C., Glavan G. and Gajović S. (2015) STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Mol. Cell. Neurosci. 67, 104–115.

Kuchukhidze G., Wieselthaler-Hölzl A., Drexel M., Unterberger I., Luef G., Ortler M., Becker A.J., Trinka E. and Sperk G. (2015) Calcium-binding proteins in focal cortical dysplasia. Epilepsia 56, 1207–1216.

Mansouri M., Kasugai Y., Fukazawa Y., Bertaso F., Raynaud F., Perroy J., Fagni L., Kaufmann W.A., Watanabe M., Shigemoto R. and Ferraguti F. (2015) Distinct subsynaptic localization of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar cortex. Eur J Neurosci 41, 157–167.

Rizzi S., Knaus H.G. and Schwarzer C. (2015) Differential distribution of the sodium-activated potassium channels Slick and Slack in mouse brain. J Comp Neurol

Tasan R.O., Verma D., Wood J., Lach G., Hörmer B., de Lima T.C., Herzog H. and Sperk G. (2015) The role of Neuropeptide Y in fear conditioning and extinction. Neuropeptides.

Theurl M., Schgoer W., Albrecht-Schgoer K., Lener D., Wolf D., Wolf M., Demetz E., Tymoszuk P., Tancevski I., Fischer-Colbrie R., Franz W.M., Marschang P. and Kirchmair R. (2015) Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E-/- mice without influencing systemic atherosclerosis. Cardiovasc. Res. 105, 96–106.

Thongrong S., Hausott B., Marvaldi L., Agostinho A.S., Zangrandi L., Burtscher J., Fogli B., Schwarzer C. and Klimaschewski L. (2015) Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. Hippocampus

Verma D., Wood J., Lach G., Mietzsch M., Weger S., Heilbronn R., Herzog H., Bonaventure P., Sperk G. and Tasan R.O. (2015) NPY Y2 receptors in the central amygdala reduce cued but not contextual fear. Neuropharmacology 99, 665–674.

Wood J., Verma D., Lach G., Bonaventure P., Herzog H., Sperk G. and Tasan R.O. (2015) Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala. Brain Struct Funct.


Brunner, S. M., Farzi, A., Locker, F., Holub, B. S., Drexel, M., Reichmann, F., Lang, A. A., Mayr, J. A., Vilches, J. J., Navarro, X., Lang, R., Sperk, G., Holzer, P. and Kofler, B. (2014) GAL3 receptor KO mice exhibit an anxiety-like phenotype. Proc Natl Acad Sci U S A 111, 7138-7143.

Burtscher M., Gatterer H., Faulhaber M. and Burtscher J. (2014) Acetazolamide pre-treatment before ascending to high altitudes: when to start? Int J Clin Exp Med 7, 4378–4383.

Gramlich, O. W., Lorenz, K., Grus, F. H., Kriechbaum, M., Ehrlich, D., Humpel, C., Fischer-Colbrie, R., Bechrakis, N. E. and Troger, J. (2014) Catestatin-like immunoreactivity in the rat eye. Neuropeptides 48, 7-13.

Hasslacher, J., Lehner, G. F., Harler, U., Beer, R., Ulmer, H., Kirchmair, R., Fischer-Colbrie, R., Bellmann, R., Dunzendorfer, S. and Joannidis, M. (2014) Secretoneurin as a marker for hypoxic brain injury after cardiopulmonary resuscitation. Intensive Care Med 40, 1518-1527.

Hintersteiner, J., Haider, M., Luger, D., Schwarzer, C., Reznicek, G., Jager, W., Khom, S., Mihovilovic, M. D. and Hering, S. (2014) Esters of valerenic acid as potential prodrugs. Eur J Pharmacol 735, 123-131.

Kardon, A. P., Polgar, E., Hachisuka, J., Snyder, L. M., Cameron, D., Savage, S., Cai, X., Karnup, S., Fan, C. R., Hemenway, G. M., Bernard, C. S., Schwartz, E. S., Nagase, H., Schwarzer, C., Watanabe, M., Furuta, T., Kaneko, T., Koerber, H. R., Todd, A. J. and Ross, S. E. (2014) Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron 82, 573-586.

Kastenberger, I. and Schwarzer, C. (2014) GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner. Horm Behav 66, 628-636.

Lange, M. D., Jungling, K., Paulukat, L., Vieler, M., Gaburro, S., Sosulina, L., Blaesse, P., Sreepathi, H. K., Ferraguti, F. and Pape, H. C. (2014) Glutamic acid decarboxylase 65: a link between GABAergic synaptic plasticity in the lateral amygdala and conditioned fear generalization. Neuropsychopharmacology 39, 2211-2220.

Menard, C., Herzog, H., Schwarzer, C. and Quirion, R. (2014) Possible role of dynorphins in Alzheimer’s disease and age-related cognitive deficits. Neurodegener Dis 13, 82-85.

Nguyen, A. D., Slack, K., Schwarzer, C., Lee, N. J., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R. F., Zhang, L., Lin, S., Shi, Y. C., Baldock, P. A., Herzog, H. and Sainsbury, A. (2014) Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides 48, 143-151.

Peitsch, W. K., Doerflinger, Y., Fischer-Colbrie, R., Huck, V., Bauer, A. T., Utikal, J., Goerdt, S. and Schneider, S. W. (2014) Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. PLoS One 9, e89491.

Prast, J. M., Schardl, A., Schwarzer, C., Dechant, G., Saria, A. and Zernig, G. (2014) Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor. Front Behav Neurosci 8, 317.

Rhomberg W. and Rhomberg T. (2014) Long-term survival in patients with incurable breast cancer. An analysis of 93 cases. Anticancer Res. 34, 5637–5642.

Strommer, B., Khom, S., Kastenberger, I., Cicek, S. S., Stuppner, H., Schwarzer, C. and Hering, S. (2014) A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice. J Pharmacol Exp Ther 351, 234-242.


Brunner J., Ster J., Van-Weert S., Andrasi T., Neubrandt M., Corti C., Corsi M., Ferraguti F., Gerber U. and Szabadics J. (2013) Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells. J. Neurosci. 33, 7285–7298.

Burtscher M., Bodner T., Burtscher J., Ruedl G., Kopp M. and Broessner G. (2013) Life-style characteristics and cardiovascular risk factors in regular downhill skiers: an observational study. BMC Public Health 13, 788.

Dobi A., Sartori S.B., Busti D., Van der Putten H., Singewald N., Shigemoto R. and Ferraguti F. (2013) Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology 66, 274–289.

Drexel, M., Kirchmair, E. and Sperk, G. (2013) Changes in the expression of GABAA receptor subunit mRNAs in parahippocampal areas after kainic acid induced seizures. Front Neural Circuits 7, 142.

Eckart S., Hörtnagl H., Kronenberg G., Gertz K., Hörster H., Endres M. and Hellweg R. (2013) Reduced nerve growth factor levels in stress-related brain regions of folate-deficient mice. Neuroscience 245, 129–135.

Eaton, S. A., Hough, T., Fischer-Colbrie, R. and Peters, J. (2013) Maternal inheritance of the Gnas cluster mutation Ex1A-T affects size, implicating NESP55 in growth. Mamm Genome 24, 276-285.

Hörtnagl H., Tasan R.O., Wieselthaler A., Kirchmair E., Sieghart W. and Sperk G. (2013) Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain. Neuroscience 236, 345–372.

Illig R., Fritsch H. and Schwarzer C. (2013) Spatio-temporal expression of HOX genes in human hindgut development. Dev Dyn 242, 53–66.

Kaufmann W.A., Matsui K., Jeromin A., Nerbonne J.M. and Ferraguti F. (2012) Kv4.2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression. Brain Struct Funct 218, 1115-1132.

Kaya L., Meissner B., Riedl M.C., Muik M., Schwarzer C., Ferraguti F., Sarg B., Lindner H., Schweigreiter R., Knaus H.G., Romanin C. and Bandtlow C.E. (2013) Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons. Biochim. Biophys. Acta 1833, 1421–1433.

Khom S., Strommer B., Schoffmann A., Hintersteiner J., Baburin I., Erker T., Schwarz T., Schwarzer C., Zaugg J., Hamburger M. and Hering S. (2013) GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Biochem. Pharmacol. 85, 1827–1836.

Menard C., Tse Y.C., Cavanagh C., Chabot J.G., Herzog H., Schwarzer C., Wong T.P. and Quirion R. (2013) Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging. J. Neurosci. 33, 12792–12804.

Romero-Pico A., Vazquez M.J., Gonzalez-Touceda D., Folgueira C., Skibicka K.P., Alvarez-Crespo M., Van Gestel M.A., Velasquez D.A., Schwarzer C., Herzog H., Lopez M., Adan R.A., Dickson S.L., Dieguez C. and Nogueiras R. (2013) Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin. Neuropsychopharmacology 38, 1296–1307.

Schmiedinger T., Vogel G.F., Eiter O., Pfaller K., Kaufmann W.A., Florl A., Gutleben K., Schönherr S., Witting B., Lechleitner T.W., Ebner H.L., Seppi T. and Hess M.W. (2013) Cryo-Immunoelectron Microscopy of Adherent Cells Improved by the Use of Electrospun Cell Culture Substrates. Traffic 14, 886-894.

Shi Y.C., Lau J., Lin Z., Zhang H., Zhai L., Sperk G., Heilbronn R., Mietzsch M., Weger S., Huang X.F., Enriquez R.F., Baldock P.A., Zhang L., Sainsbury A., Herzog H. and Lin S. (2013) Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metab 17, 236–248.

Whittle N., Schmuckermair C., Gunduz Cinar O., Hauschild M., Ferraguti F., Holmes A. and Singewald N. (2013) Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model. Neuropharmacology 64, 414–423.


Albrecht-Schgoer K., Schgoer W., Holfeld J., Theurl M., Wiedemann D., Steger C., Gupta R., Semsroth S., Fischer-Colbrie R., Beer A.G., Stanzl U., Huber E., Misener S., Dejaco D., Kishore R., Pachinger O., Grimm M., Bonaros N. and Kirchmair R. (2012) The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells. Circulation 126, 2491–2501.

Baldock P.A., Driessler F., Lin S., Wong I.P., Shi Y., Yulyaningsih E., Castillo L., Janmaat S., Enriquez R.F., Zengin A., Kieffer B.L., Schwarzer C., Eisman J.A., Sainsbury A. and Herzog H. (2012) The endogenous opioid dynorphin is required for normal bone homeostasis in mice. Neuropeptides 46, 383–394.

Bienvenu T.C., Busti D., Magill P.J., Ferraguti F. and Capogna M. (2012) Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo. Neuron 74, 1059–1074.

Blumer M.J., Hausott B., Schwarzer C., Hayman A.R., Stempel J. and Fritsch H. (2012) Role of tartrate-resistant acid phosphatase (TRAP) in long bone development. Mech. Dev. 129, 162-176.

Denby K.S., Briones A.J., Bourne P.A., Spaulding B.O., Lu D., Fischer-Colbrie R., Qu Z., Wang H.L. and Xu H. (2012) IMP3, NESP55, TTF-1 and CDX2 Serve as an Immunohistochemical Panel in the Distinction Among Small-cell Carcinoma, Gastrointestinal Carcinoid, and Pancreatic Endocrine Tumor Metastasized to the Liver. Appl. Immunohistochem. Mol. Morphol.  20, 573–579.

Drexel M., Kirchmair E., Wieselthaler-Holzl A., Preidt A.P. and Sperk G. (2012) Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy. J Neuropathol. Exp. Neurol. 71, 312–329.

Drexel M., Preidt A.P. and Sperk G. (2012) Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. Neuropharmacology 63, 806–817.

Eberhard N., Mayer C., Santic R., Navio R.P., Wagner A., Bauer H.C., Sperk G., Boehm U. and Kofler B. (2012) Distribution of alarin immunoreactivity in the mouse brain. J. Mol. Neurosci. 46, 18–32.

Geracitano R., Fischer D., Kasugai Y., Ferraguti F. and Capogna M. (2012) Functional expression of the GABA(A) receptor alpha2 and alpha3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala. Front Neural Circuits 6, 32.

Hausott B., Vallant N., Schlick B., Auer M., Nimmervoll B., Obermair G.J., Schwarzer C., Dai F., Brand-Saberi B. and Klimaschewski L. (2012) Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons. Hippocampus 22, 434-441.

Kastenberger I., Lutsch C., Herzog H. and Schwarzer C. (2012) Influence of sex and genetic background on anxiety-related and stress-induced behaviour of prodynorphin-deficient mice. PLoS ONE 7, e34251

Kastenberger I., Lutsch C. and Schwarzer C. (2012) Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol. Psychopharmacology (Berl) 221, 527–535.

Krabichler B., Rostasy K., Baumann M., Karall D., Scholl-Burgi S., Schwarzer C., Gautsch K., Spreiz A., Kotzot D., Zschocke J., Fauth C. and Haberlandt E. (2012) Novel Mutation in Potassium Channel related Gene KCTD7 and Progressive Myoclonic Epilepsy. Ann. Hum. Genet.  76, 326–331.

Lorenz K., Gramlich O.W., Grus F.H., Ehrlich D., Humpel C., Nogalo M., Fischer-Colbrie R., Bechrakis N.E., Hattmannstorfer R. and Troger J. (2012) GE-25-like immunoreactivity in the rat eye. Peptides 36, 286–291.

Schmid E., Nogalo M., Bechrakis N.E., Fischer-Colbrie R., Tasan R., Sperk G., Theurl M., Beer A.G., Kirchmair R., Herzog H. and Troger J. (2012) Secretoneurin, substance P and neuropeptide Y in the oxygen-induced retinopathy in C57Bl/6N mice. Peptides 37, 252–257.

Sperk G., Wieselthaler-Holzl A., Pirker S., Tasan R., Strasser S.S., Drexel M., Pifl C., Marschalek J., Ortler M., Trinka E., Heitmair-Wietzorrek K., Ciofi P., Feucht M., Baumgartner C. and Czech T. (2012) Glutamate decarboxylase 67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients. Hippocampus 22, 590–603.

Sreepathi H.K. and Ferraguti F. (2012) Subpopulations of neurokinin 1 receptor-expressing neurons in the rat lateral amygdala display a differential pattern of innervation from distinct glutamatergic afferents. Neuroscience 203, 59–77.

Stefanova N., Kaufmann W.A., Humpel C., Poewe W. and Wenning G.K. (2012) Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. Acta Neuropathol.  124, 51–65.

Verma D., Tasan R., Herzog H. and Sperk G. (2012) NPY controls fear conditioning and fear extinction by combined action on Y(1) and Y(2) receptors. Br. J. Pharmacol. 166, 1461–1473.


Bartolomucci A., Possenti R., Mahata S.K., Fischer-Colbrie R., Loh Y.P. and Salton S.R. (2011) The extended granin family: structure, function, and biomedical implications. Endocr. Rev. 32, 755–797.

Busti D., Geracitano R., Whittle N., Dalezios Y., Manko M., Kaufmann W., Satzler K., Singewald N., Capogna M. and Ferraguti F. (2011) Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala. J. Neurosci. 31, 5131–5144.

Corti C., Xuereb J.H., Crepaldi L., Corsi M., Michielin F. and Ferraguti F. (2011) Altered levels of glutamatergic receptors and Na(+)/K(+) ATPase-alpha1 in the prefrontal cortex of subjects with schizophrenia. Schizophr. Res. 128, 7-14.

Drexel M., Preidt A.P., Kirchmair E. and Sperk G. (2011) Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures. Neuroscience 189, 316–329.

Gupta M., Lloyd R.V., Fischer-Colbrie R., Tischler A.S. and Dayal Y. (2011) Immunohistochemical expression of neuroendocrine secretory protein-55 (NESP-55) in pituitary adenomas. Endocr. Pathol. 22, 150–154.

Lorenz K., Troger J., Gramlich O., Grus F., Hattmannstorfer R., Fischer-Colbrie R., Joachim S., Schmid E., Teuchner B., Haas G. and Bechrakis N. (2011) PE-11, a peptide derived from chromogranin B, in the rat eye. Peptides 32, 1201-1206.

Ngomba R.T., Santolini I., Biagioni F., Molinaro G., Simonyi A., van Rijn C.M., D’Amore V., Mastroiacovo F., Olivieri G., Gradini R., Ferraguti F., Battaglia G., Bruno V., Puliti A., van Luijtelaar G. and Nicoletti F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology 60, 1281-1291.

Ngomba R.T., Santolini I., Salt T.E., Ferraguti F., Battaglia G., Nicoletti F. and van Luijtelaar G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia 52, 1211–1222.

Nicoletti F., Bockaert J., Collingridge G.L., Conn P.J., Ferraguti F., Schoepp D.D., Wroblewski J.T. and Pin J.P. (2011) Metabotropic glutamate receptors: From the workbench to the bedside. Neuropharmacology. 60, 1017-1041.

Painsipp E., Herzog H., Sperk G. and Holzer P. (2011) Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y. Br. J. Pharmacol. 163, 1302-1314.

Pavlov I., Huusko N., Drexel M., Kirchmair E., Sperk G., Pitkanen A. and Walker M.C. (2011) Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats. Neuroscience 194, 208–219.

Schunk E., Aigner C., Stefanova N., Wenning G., Herzog H. and Schwarzer C. (2011) Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection. Hippocampus 21, 1010–1020.

Tasan R.O., Bukovac A., Peterschmitt Y.N., Sartori S.B., Landgraf R., Singewald N. and Sperk G. (2011) Altered GABA transmission in a mouse model of increased trait anxiety. Neuroscience 183, 71-80.

Teuchner B., Dimmer A., Humpel C., Amberger A., Fischer-Colbrie R., Nemeth J., Waschek J.A., Kieselbach G., Kralinger M., Schmid E., Bechrakis N. and Troger J. (2011) VIP, PACAP-38, BDNF and ADNP in NMDA-induced excitotoxicity in the rat retina. Acta Ophthalmol. 89, 670-675.

Zambello E., Zanetti L., Hedou G.F., Angelici O., Arban R., Tasan R.O., Sperk G. and Caberlotto L. (2011) Neuropeptide Y-Y2 receptor knockout mice: influence of genetic background on anxiety-related behaviors. Neuroscience 176, 420–430.

Zhao E., McNeilly J.R., McNeilly A.S., Fischer-Colbrie R., Basak A., Seong J.Y. and Trudeau V.L. (2011) Secretoneurin stimulates the production and release of luteinizing hormone in mouse LßT2 gonadotropin cells. Am. J. Physiol. Endocrinol. Metab. 301, E288–97.


Allerstorfer D., Longato S., Schwarzer C., Fischer-Colbrie R., Hayman A.R. and Blumer M.J. (2010) VEGF and its role in the early development of the long bone epiphysis. J. Anat. 216, 611–624.

Hedborg F., Fischer-Colbrie R., Ostlin N., Sandstedt B., Tran M.G. and Maxwell P.H. (2010) Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. PLoS ONE 5, e12825.

Herry C., Ferraguti F., Singewald N., Letzkus J.J., Ehrlich I. and Luthi A. (2010) Neuronal circuits of fear extinction. Eur. J. Neurosci. 31, 599–612.

Illig R., Fritsch H. and Schwarzer C. (2010) Efficient mRNA detection from human archival paraffin-embedded tissue: An update. RNA 16, 1446.

Kasugai Y., Swinny J.D., Roberts J.D., Dalezios Y., Fukazawa Y., Sieghart W., Shigemoto R. and Somogyi P. (2010) Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Eur J Neurosci 32, 1868–1888.

Kaufmann W.A., Kasugai Y., Ferraguti F. and Storm J.F. (2010) Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neurons. Neuroscience 169, 974–986.

Khom S., Strommer B., Ramharter J., Schwarz T., Schwarzer C., Erker T., Ecker G.F., Mulzer J. and Hering S. (2010) Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. Br. J. Pharmacol. 161, 65–78.

Lang L., Ingorokva S., Hausott B., Vallant N., Schmidt S., Schwarzer C. and Klimaschewski L. (2010) Selective up-regulation of the vasodilator peptide apelin after dorsal root but not after spinal nerve injury. Neuroscience 170, 954–960.

Mazzuferi M., Palma E., Martinello K., Maiolino F., Roseti C., Fucile S., Fabene P.F., Schio F., Pellitteri M., Sperk G., Miledi R., Eusebi F. and Simonato M. (2010) Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proc. Natl. Acad. Sci. USA 107, 3180–3185.

Möbius W., Cooper B., Kaufmann W.A., Imig C., Ruhwedel T., Snaidero N., Saab A.S. and Varoqueaux F. (2010) Electron microscopy of the mouse central nervous system. Methods Cell Biol. 96, 475–512.

Noe F., Vaghi V., Balducci C., Fitzsimons H., Bland R., Zardoni D., Sperk G., Carli M., During M.J. and Vezzani A. (2010) Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus. Gene Ther. 17, 643–652.

Painsipp E., Sperk G., Herzog H. and Holzer P. (2010) Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice. J. Psychopharmacol. 24, 1541-1549.

Tasan R.O., Nguyen N.K., Weger S., Sartori S.B., Singewald N., Heilbronn R., Herzog H. and Sperk G. (2010) The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression. J. Neurosci. 30, 6282–6290.

Teuchner B., Dimmer A., Troger J., Fischer-Colbrie R., Schmid E., Kieselbach G., Dietrich H. and Bechrakis N. (2010) Secretoneurin and the tachykinins substance P and neurokinin-A/B in NMDA-induced excitotoxicity in the rat retina. Regul. Pept. 165, 123-127.

Willis M., Kaufmann W.A., Wietzorrek G., Hutter-Paier B., Moosmang S., Humpel C., Hofmann F., Windisch M., Gunther Knaus H. and Marksteiner J. (2010) L-Type Calcium Channel Ca{V} 1.2 in Transgenic Mice Overexpressing Human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) Mutations. J. Alzheimers Dis. 20, 1167-1180.


Hermann-Kleiter N., Ghaffari-Tabrizi N., Blumer M.J., Schwarzer C., Mazur M.A. and Artner I. (2009) Lasp1 misexpression influences chondrocyte differentiation in the vertebral column. Int. J. Dev. Biol. 53, 983-991.

Illig R., Fritsch H. and Schwarzer C. (2009) Breaking the seals: efficient mRNA detection from human archival paraffin-embedded tissue. RNA 15, 1588–1596.

Kaufmann W.A., Ferraguti F., Fukazawa Y., Kasugai Y., Shigemoto R., Laake P., Sexton J.A., Ruth P., Wietzorrek G., Knaus H.G., Storm J.F. and Ottersen O.P. (2009) Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains. J. Comp. Neurol. 515, 215–230.

Kratzer I., Bernhart E., Wintersperger A., Hammer A., Waltl S., Malle E., Sperk G., Wietzorrek G., Dieplinger H. and Sattler W. (2009) Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier. J. Neurochem. 108, 707–718.

Nguyen N.K., Sartori S.B., Herzog H., Tasan R., Sperk G. and Singewald N. (2009) Effect of neuropeptide Y Y2 receptor deletion on emotional stress-induced neuronal activation in mice. Synapse 63, 236–246.

Noe F., Frasca A., Balducci C., Carli M., Sperk G., Ferraguti F., Pitkanen A., Bland R., Fitzsimons H., During M. and Vezzani A. (2009) Neuropeptide Y overexpression using recombinant adeno-associated viral vectors. Neurotherapeutics 6, 300–306.

Paco S., Margeli M.A., Olkkonen V.M., Imai A., Blasi J., Fischer-Colbrie R. and Aguado F. (2009) Regulation of exocytotic protein expression and Ca2+-dependent peptide secretion in astrocytes. J. Neurochem. 110, 143–156.

Pirker S., Gasser E., Czech T., Baumgartner C., Schuh E., Feucht M., Novak K., Zimprich F. and Sperk G. (2009) Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy. Hippocampus 19, 1051–1054.

Schgoer W., Theurl M., Jeschke J., Beer A.G., Albrecht K., Gander R., Rong S., Vasiljevic D., Egger M., Wolf A.M., Frauscher S., Koller B., Tancevski I., Patsch J.R., Schratzberger P., Piza-Katzer H., Ritsch A., Bahlmann F.H., Fischer-Colbrie R., Wolf D. and Kirchmair R. (2009) Gene therapy with the angiogenic cytokine secretoneurin induces therapeutic angiogenesis by a nitric oxide-dependent mechanism. Circ. Res. 105, 994–1002.

Schwarzer C. (2009) 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases. Pharmacol. Ther. 123, 353–370.

Sperk G., Drexel M. and Pirker S. (2009) Neuronal plasticity in animal models and the epileptic human hippocampus. Epilepsia 50 Suppl 12, 29–31.

Subramanyam P., Obermair G.J., Baumgartner S., Gebhart M., Striessnig J., Kaufmann W.A., Geley S. and Flucher B.E. (2009) Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells. Channels (Austin) 3, 343–355.

Tasan R.O., Lin S., Hetzenauer A., Singewald N., Herzog H. and Sperk G. (2009) Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice. Neuroscience 158, 1717–1730.

Wittmann W., Schunk E., Rosskothen I., Gaburro S., Singewald N., Herzog H. and Schwarzer C. (2009) Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. Neuropsychopharmacology 34, 775–785.


Balastik M., Ferraguti F., Pires-da Silva A., Lee T.H., Alvarez-Bolado G., Lu K.P. and Gruss P. (2008) Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc. Natl. Acad. Sci. USA 105, 12016–12021.

Boscia F., Ferraguti F., Moroni F., Annunziato L. and Pellegrini-Giampietro D.E. (2008) mGlu1alpha receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain. Neuropharmacology 55, 428–439.

Ebner K., Singewald G.M., Whittle N., Ferraguti F. and Singewald N. (2008) Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission. Neuropsychopharmacology 33, 1929–1941.

Ferraguti F., Crepaldi L. and Nicoletti F. (2008) Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol Rev 60, 536–581.

Hetzenauer A., Corti C., Herdy S., Corsi M., Ferraguti F. and Singewald N. (2008) Individual contribution of metabotropic glutamate receptor (mGlu) 2 and 3 to c-Fos expression pattern evoked by mGlu2/3 antagonism. Psychopharmacology 201, 1–13.

Li Y., Fischer-Colbrie R. and Dahlström A. (2008) Neuroendocrine secretory protein 55 (NESP55) in the spinal cord of rat: an immunocytochemical study. J. Comp. Neurol. 506, 733–744.

Lorenz K., Troger J., Fischer-Colbrie R., Kremser B., Schmid E., Kralinger M., Teuchner B., Bechrakis N. and Kieselbach G. (2008) Substance P and secretoneurin in vitreous aspirates of patients with various vitreoretinal diseases. Peptides 29, 1561–1565.

Ngomba R.T., Ferraguti F., Badura A., Citraro R., Santolini I., Battaglia G., Bruno V., De Sarro G., Simonyi A., van Luijtelaar G. and Nicoletti F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology 54, 344–354.

Noe F., Pool A.H., Nissinen J., Gobbi M., Bland R., Rizzi M., Balducci C., Ferraguti F., Sperk G., During M.J., Pitkanen A. and Vezzani A. (2008) Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Brain 131, 1506–1515.

Painsipp E., Wultsch T., Edelsbrunner M.E., Tasan R.O., Singewald N., Herzog H. and Holzer P. (2008) Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice. Genes Brain Behav 7, 532–542.

Singewald N., Chicchi G.G., Thurner C.C., Tsao K.L., Spetea M., Schmidhammer H., Sreepathi H.K., Ferraguti F., Singewald G.M. and Ebner K. (2008) Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429. J. Neurochem. 106, 2476-2488.


Blumer M.J., Longato S., Schwarzer C. and Fritsch H. (2007) Bone development in the femoral epiphysis of mice: The role of cartilage canals and the fate of resting chondrocytes. Dev. Dynamics 236, 2077–2088.

Corti C., Crepaldi L., Mion S., Roth A.L., Xuereb J.H. and Ferraguti F. (2007) Altered dimerization of metabotropic glutamate receptor 3 in schizophrenia. Biol. Psychiatry 62, 747–755.

Crepaldi L., Lackner C., Corti C. and Ferraguti F. (2007) Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor. J. Biol. Chem. 282, 17877–17889.

Druckenthaner M., Schwarzer C., Ensinger C., Gabriel M., Prommegger R., Riccabona G. and Decristoforo C. (2007) Evidence for somatostatin receptor 2 in thyroid tissue. Regul. Pept. 138, 32–39.

Egger M., Schgoer W., Beer A.G., Jeschke J., Leierer J., Theurl M., Frauscher S., Tepper O.M., Niederwanger A., Ritsch A., Kearney M., Wanschitz J., Gurtner G.C., Fischer-Colbrie R., Weiss G., Piza-Katzer H., Losordo D.W., Patsch J.R., Schratzberger P. and Kirchmair R. (2007) Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1alpha- and basic FGF-dependent pathway in muscle cells. FASEB J. 21, 2906–2917.

Fritsch H., Aigner F., Ludwikowski B., Reinstadler-Zankl S., Illig R., Urbas D., Schwarzer C. and Longato S. (2007) Epithelial and muscular regionalization of the human developing anorectum. Anat Rec (Hoboken) 290, 1449–1458.

Geracitano R., Kaufmann W., Szabo G., Ferraguti F. and Capogna M. (2007) Synaptic heterogeneity between mouse paracapsular intercalated neurons of the amygdala. J. Physiol. 585, 117-134.

Kuramoto E., Fujiyama F., Unzai T., Nakamura K., Hioki H., Furuta T., Shigemoto R., Ferraguti F. and Kaneko T. (2007) Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. J. Comp. Neurol. 500, 908–922.

Loacker S., Sayyah M., Wittmann W., Herzog H. and Schwarzer C. (2007) Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors. Brain 130, 1017–1028.

Noe' F., Nissinen J., Pitkänen A., Gobbi M., Sperk G., During M. and Vezzani A. (2007) Gene therapy in epilepsy: the focus on NPY. Peptides 28, 377–383.

Sainsbury A., Lin S., McNamara K., Slack K., Enriquez R., Lee N.J., Boey D., Smythe G.A., Schwarzer C., Baldock P., Karl T., Lin E.J., Couzens M. and Herzog H. (2007) Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice. Mol. Endocrinol. 21, 1722–1735.

Sperk G. (2007) Changes in GABAA receptors in status epilepticus. Epilepsia 48 Suppl 8, 11–13.

Sperk G., Hamilton T. and Colmers W.F. (2007) Neuropeptide Y in the dentate gyrus. Prog. Brain Res. 163, 285–297.


Bitsche M., Schrott-Fischer A., Hinterhoelzl J., Fischer-Colbrie R., Sergi C., Glueckert R., Humpel C. and Marksteiner J. (2006) First localization and biochemical identification of chromogranin B- and secretoneurin-like immunoreactivity in the fetal human vagal/nucleus solitary complex. Regul. Pept. 134, 97-104.

Blumer M. J., Schwarzer C., Perez M. T., Konakci K. Z. and Fritsch H. (2006) Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre. J. Anat. 208, 695-707.

Ferraguti F. and Shigemoto R. (2006) Metabotropic glutamate receptors. Cell Tissue Res. 326, 483-504.

Lin S., Boey D., Lee N., Schwarzer C., Sainsbury A. and Herzog H. (2006) Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain. Neuropeptides 40, 115-123.

Reginster J. Y., Abadie E., Delmas P., Rizzoli R., Dere W., van der Auwera P., Avouac B., Brandi M. L., Daifotis A., Diez-Perez A., Calvo G., Johnell O., Kaufman J. M., Kreutz G., Laslop A., Lekkerkerker F., Mitlak B., Nilsson P., Orloff J., Smillie M., Taylor A., Tsouderos Y., Ethgen D. and Flamion B. (2006) Recommendations for an update of the current (2001) regulatory requirements for registration of drugs to be used in the treatment of osteoporosis in postmenopausal women and in men. Osteoporos. Int. 17, 1-7.

Sailer C.A., Kaufmann W.A., Kogler M., Chen L., Sausbier U., Ottersen O.P., Ruth P., Shipston M.J. and Knaus H.G. (2006) Immunolocalization of BK channels in hippocampal pyramidal neurons. Eur J Neurosci 24, 442–454.

Sainsbury A., Bergen H. T., Boey D., Bamming D., Cooney G. J., Lin S., Couzens M., Stroth N., Lee N. J., Lindner D., Singewald N., Karl T., Duffy L., Enriquez R., Slack K., Sperk G. and Herzog H. (2006) Y2Y4 Receptor Double Knockout Protects Against Obesity Due to a High-Fat Diet or Y1 Receptor Deficiency in Mice. Diabetes 55, 19-26.

Schmid E., Leierer J., Kieselbach G., Teuchner B., Kralinger M., Fischer-Colbrie R., Krause J.E., Nguyen Q.A., Haas G., Stemberger K. and Troger J. (2006) Neurokinin A and neurokinin B in the human retina. Peptides 27, 3370-3376.

Wultsch T., Painsipp E., Donner S., Sperk G., Herzog H., Peskar B. A. and Holzer P. (2006) Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice. Behav. Brain Res. 168, 255-260.


Abadie E. C., Devogealer J. P., Ringe J. D., Ethgen D. J., Bouvenot G. M., Kreutz G., Laslop A., Orloff J. J., van der Auwera P. M., Delmas P. D., Dere W. H., Branco J., Altman R. D., Avouac B. P., Menkes C. J., Vanhaelst L., Mitlak B. H., Tsouderos Y. and Reginster J. Y. (2005) Recommendations for the registration of agents to be used in the prevention and treatment of glucocorticoid-induced osteoporosis: updated recommendations from the Group for the Respect of Ethics and Excellence in Science. Semin. Arthritis Rheum. 35, 1-4.

Altman R. D., Abadie E., Avouac B., Bouvenot G., Branco J., Bruyere O., Calvo G., Devogelaer J. P., Dreiser R. L., Herrero-Beaumont G., Kahan A., Kreutz G., Laslop A., Lemmel E. M., Menkes C. J., Pavelka K., Van De Putte L., Vanhaelst L. and Reginster J. Y. (2005) Total joint replacement of hip or knee as an outcome measure for structure modifying trials in osteoarthritis. Osteoarthritis Cartilage 13, 13-19.

Csaba Z., Pirker S., Lelouvier B., Simon A., Videau C., Epelbaum J., Czech T., Baumgartner C., Sperk G. and Dournaud P. (2005) Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus. J. Neuropathol. Exp. Neurol. 64, 956-969.

El Bahh B., Balosso S., Hamilton T., Herzog H., Beck-Sickinger A. G., Sperk G., Gehlert D. R., Vezzani A. and Colmers W. F. (2005) The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors. Eur. J. Neurosci. 22, 1417-1430.

Ferraguti F., Klausberger T., Cobden P., Baude A., Roberts J. D., Szucs P., Kinoshita A., Shigemoto R., Somogyi P. and Dalezios Y. (2005) Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. J. Neurosci. 25, 10520-10536.

Fischer-Colbrie R., Kirchmair R., Kähler C. M., Wiedermann C. J. and Saria A. (2005) Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system. Curr. Protein Pept. Sci. 6, 373-385.

Korsgren M., Fischer-Colbrie R., Andersson M., Coman W. B., Mackay-Sim A., Persson C. G., Sundler F., Wallwork B. and Greiff L. (2005) Secretoneurin is released into human airways by topical histamine but not capsaicin. Allergy 60, 459-463.

Nishimura T., Schwarzer C., Gasser E., Kato N., Vezzani A. and Sperk G. (2005) Altered expression of GABA(a) and GABA(b) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. Neuroscience 134, 691-704.

Plagge A., Isles A. R., Gordon E., Humby T., Dean W., Gritsch S., Fischer-Colbrie R., Wilkinson L. S. and Kelsey G. (2005) Imprinted nesp55 influences behavioral reactivity to novel environments. Mol. Cell. Biol. 25, 3019-3026.

Schmid E., Leierer J., Doblinger A., Laslop A., Fischer-Colbrie R., Humpel C., Theodorsson E., Teuchner B., Lalehabbasi D., Dragosits E., Kunze C., Philipp W., Gottinger W. and Troger J. (2005) Neurokinin a is a main constituent of sensory neurons innervating the anterior segment of the eye. Invest Ophthalmol Vis Sci 46, 268-274.

Scimemi A., Semyanov A., Sperk G., Kullmann D. M. and Walker M. C. (2005) Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus. J Neurosci 25, 10016-10024.

Troger J., Doblinger A., Leierer J., Laslop A., Schmid E., Teuchner B., Opatril M., Philipp W., Klimaschewski L., Pfaller K., Gottinger W. and Fischer-Colbrie R. (2005) Secretoneurin in the peripheral ocular innervation. Invest Ophthalmol Vis Sci 46, 647-654.

Wittmann W., Loacker S., Kapeller I., Herzog H. and Schwarzer C. (2005) Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. Neuroscience 136, 241-250.

Wultsch T., Painsipp E., Thoeringer C. K., Herzog H., Sperk G. and Holzer P. (2005) Endogenous neuropeptide Y depresses the afferent signaling of gastric acid challenge to the mouse brainstem via neuropeptide Y type Y2 and Y4 receptors. Neuroscience 136, 1097-1107.


Abadie E., Ethgen D., Avouac B., Bouvenot G., Branco J., Bruyere O., Calvo G., Devogelaer J. P., Dreiser R. L., Herrero-Beaumont G., Kahan A., Kreutz G., Laslop A., Lemmel E. M., Nuki G., Van De Putte L., Vanhaelst L. and Reginster J. Y. (2004) Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis. Osteoarthritis Cartilage 12, 263-268.

Bandtlow C. E., Dlaska M., Pirker S., Czech T., Baumgartner C. and Sperk G. (2004) Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy. Eur J Neurosci 20, 195-206.

Berger A. P., Niescher M., Fischer-Colbrie R., Pelzer A., Bartsch G. and Horninger W. (2004) Single-agent chemotherapy with docetaxel significantly reduces PSA levels in patients with high-grade localized prostate cancers. Urol Int 73, 110-112.

Eder S., Leierer J., Klimaschewski L., Wilhelm A., Volknandt W., Laslop A. and Fischer-Colbrie R. (2004) Secretion and molecular forms of NESP55, a novel genomically imprinted neuroendocrine-specific protein from AtT-20 cells. Neurosignals 13, 298-307.

Karl T., Lin S., Schwarzer C., Sainsbury A., Couzens M., Wittmann W., Boey D., von Hörsten S. and Herzog H. (2004) Y1 receptors regulate aggressive behavior by modulating serotonin pathways. Proc Natl Acad Sci U S A 101, 12742-12747.

Kirchmair R., Gander R., Egger M., Hanley A., Silver M., Ritsch A., Murayama T., Kaneider N., Sturm W., Kearny M., Fischer-Colbrie R., Kircher B., Gaenzer H., Wiedermann C. J., Ropper A. H., Losordo D. W., Patsch J. R. and Schratzberger P. (2004) The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo. Circulation 109, 777-783.

Kirchmair R., Egger M., Walter D. H., Eisterer W., Niederwanger A., Woell E., Nagl M., Pedrini M., Murayama T., Frauscher S., Hanley A., Silver M., Brodmann M., Sturm W., Fischer-Colbrie R., Losordo D. W., Patsch J. R. and Schratzberger P. (2004) Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis. Circulation 110, 1121-1127.

Malosio M. L., Giordano T., Laslop A. and Meldolesi J. (2004) Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype. J. Cell Sci. 117, 743-749.

Richichi C., Lin E. J., Stefanin D., Colella D., Ravizza T., Grignaschi G., Veglianese P., Sperk G., During M. J. and Vezzani A. (2004) Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus. J. Neurosci. 24, 3051-3059.

Sperk G., Furtinger S., Schwarzer C. and Pirker S. (2004) GABA and its receptors in epilepsy. Adv Exp Med Biol 548, 92-103.

Srivastava A., Padilla O., Fischer-Colbrie R., Tischler A. S. and Dayal Y. (2004) Neuroendocrine Secretory Protein-55 (NESP-55) Expression Discriminates Pancreatic Endocrine Tumors and Pheochromocytomas From Gastrointestinal and Pulmonary Carcinoids. Am. J. Surg. Pathol 28., 1371-1378.

Stemberger K., Pallhuber J., Doblinger A., Troger J., Kirchmair R., Kralinger M., Fischer-Colbrie R. and Kieselbach G. (2004) Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels. Peptides 25, 2115-2118.

Vezzani A. and Sperk G. (2004) Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy? Neuropeptides 38, 245-252.


Corti C., Clarkson R. W., Crepaldi L., Sala C. F., Xuereb J. H. and Ferraguti F. (2003) Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. J Biol Chem 278, 33105-33119.

Devogelaer J. P., Dreiser R. L., Abadie E., Avouac B., Bouvenot G., Carbonell Abello J., Kaufman J. M., Koes B. W., Laslop A., Lemmel E., Richy F., Rozenberg S., Tavares V., Valat J. P. and Reginster J. Y. (2003) Guidelines for clinical studies assessing the efficacy of drugs for the management of acute low back pain. Clin Exp Rheumatol 21, 691-694.

Doblinger A., Becker A., Seidah N. G. and Laslop A. (2003) Proteolytic processing of chromogranin A by the prohormone convertase PC2. Regul Pept 111, 111-116.

Furtinger S., Bettler B. and Sperk G. (2003) Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats. Brain Res Mol Brain Res 113, 107-115.

Furtinger S., Pirker S., Czech T., Baumgartner C. and Sperk G. (2003) Increased expression of g-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy. Neurosci Lett 352, 141-145.

Gasser M. C., Berti I., Hauser K. F., Fischer-Colbrie R. and Saria A. (2003) Secretoneurin promotes pertussis toxin-sensitive neurite outgrowth in cerebellar granule cells. J Neurochem 85, 662-669.

Hinterhoelzl J. K., Salimi K., Humpel C., Singewald N., Adlassnig C., Fischer-Colbrie R., Fleischhacker W. W. and Marksteiner J. (2003) Differential effects of phencyclidine application on secretogranin II expression in organotypic slices of rat prefrontal cortex. J Neurochem 87, 13-21.

Jakobsen A. M., Ahlman H., Kolby L., Abrahamsson J., Fischer-Colbrie R. and Nilsson O. (2003) NESP55, a novel chromogranin-like peptide, is expressed in endocrine tumours of the pancreas and adrenal medulla but not in ileal carcinoids. Br J Cancer 88, 1746-1754.

Korsgren M., Erjefalt J. S., Hinterholzl J., Fischer-Colbrie R., Emanuelsson C. A., Andersson M., Persson C. G., Mackay-Sim A., Sundler F. and Greiff L. (2003) Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitis. Am J Respir Crit Care Med 167, 1504-1508.

Kralinger M. T., Hinterholzl J., Troger J., Nguyen Q. A., Kremser B., Fischer-Colbrie R. and Kieselbach G. F. (2003) Elevated levels of secretoneurin in the rabbit aqueous humor in response to formaldehyde irritation. Graefes Arch Clin Exp Ophthalmol 241, 577-581.

Pirker S., Schwarzer C., Czech T., Baumgartner C., Pockberger H., Maier H., Hauer B., Sieghart W., Furtinger S. and Sperk G. (2003) Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy. J Neuropathol Exp Neurol 62, 820-834.

Sperk G., Schwarzer C., Heilman J., Furtinger S., Reimer R. J., Edwards R. H. and Nelson N. (2003) Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Hippocampus 13, 806-815.

Tschenett A., Singewald N., Carli M., Balducci C., Salchner P., Vezzani A., Herzog H. and Sperk G. (2003) Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur J Neurosci 18, 143-148.


Delmas P. D., Calvo G., Boers M., Abadie E., Avouac B., Kahan A., Kaufman J. M., Laslop A., Lekkerkerker J. F., Nilsson P., Van Z. B., Kreutz G. and Reginster J. Y. (2002) The use of placebo-controlled and non-inferiority trials for the evaluation of new drugs in the treatment of postmenopausal osteoporosis. Osteoporos Int 13, 1-5.

Fischer-Colbrie R., Eder S., Lovisetti-Scamihorn P., Becker A. and Laslop A. (2002) Neuroendocrine secretory protein 55: a novel marker for the constitutive secretory pathway. Ann N Y Acad Sci 971, 317-322.

Fürtinger S., Pirker S., Czech T., Baumgartner C. and Sperk G. (2002) Altered expression of neuropeptide y, -y1, and -y2 receptors in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia 43 Suppl 5, 152.

Kaneider N. C., Djanani A., Fischer-Colbrie R. and Wiedermann C. J. (2002) Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester. Biochem Biophys Res Commun 297, 806-810.

Laslop A. and Mahata S. K. (2002) Neuropeptides and chromogranins: session overview. Ann N Y Acad Sci 971, 294-299.

Laslop A., Becker A., Lindberg I. and Fischer-Colbrie R. (2002) Proteolytic processing of chromogranins is modified in brains of transgenic mice. Ann N Y Acad Sci 971, 49-52.

Li J. Y., Lovisetti-Scamihorn P., Fischer-Colbrie R., Winkler H. and Dahlström A. (2002) Distribution and intraneuronal trafficking of a novel member of the chromogranin family, NESP55, in the rat peripheral nervous system. Neuroscience 110, 731-745.

Sailer C. A., Hu H., Kaufmann W. A., Trieb M., Schwarzer C., Storm J. F. and Knaus H. G. (2002) Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain. J Neurosci 22, 9698-9707.

Sainsbury A., Schwarzer C., Couzens M., Fetissov S., Furtinger S., Jenkins A., Cox H. M., Sperk G., Hokfelt T. and Herzog H. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci U S A 99, 8938-8943.

Sieghart W. and Sperk G. (2002) Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr Top Med Chem 2, 795-816.

Vezzani A., Michalkiewicz M., Michalkiewicz T., Moneta D., Ravizza T., Richichi C., Aliprandi M., Mule F., Pirona L., Gobbi M., Schwarzer C. and Sperk G. (2002) Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y. Neuroscience 110, 237-243.

Wakonigg G., Zernig G., Berger I., Fischer-Colbrie R., Laslop A. and Saria A. (2002) Lack of a distinctive behavioural effect of chromogranin-derived peptides in rodents. Regul Pept 103, 85-91.


Fürtinger S., Pirker S., Czech T., Baumgartner C., Ransmayr G., and Sperk G. (2001) Plasticity of y1 and y2 receptors and neuropeptide y fibers in patients with temporal lobe epilepsy. J Neurosci 21, 5804-5812.

Marksteiner J., Weiss U., Weis C., Laslop A., Fischer-Colbrie R., Humpel C., Feldon J., and Fleischhacker W.W. (2001) Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment. Neuroscience 104, 325-333.

Nishimura T., Schwarzer C., Furtinger S., Imai H., Kato N., and Sperk G. (2001) Changes in the GABA-ergic system induced by trimethyltin application in the rat. Brain Res Mol Brain Res 97, 1-6.

Pirker S., Czech T., Baumgartner C., Maier H., Novak K., Furtinger S., Fischer-Colbrie R., and Sperk G. (2001) Chromogranins as markers of altered hippocampal circuitry in temporal lobe epilepsy. Ann Neurol 50, 216-226.

Schwarzer C., Berresneim U., Pirker S., Wieselthaler A., Fuchs K., Sieghart W., and Sperk G. (2001) Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol 433, 526-549.

Weiss C., Winkler H., and Laslop A. (2001) Regulation of chromogranin biosynthesis by neurotrophic growth factors in neuroblastoma cells. Neurochem. Int. 38, 43-52.


Bauer R., Mayr A., Lederer W., Needham P. L., Kilpatrick I. C., Fleischhacker W. W., and Marksteiner J. (2000) Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs. Neuropsychopharmacology 23, 46-55.

Bauer R., Hoflehner J., Doblinger A., Kapeller I., and Laslop A. (2000) Regulation of the biosynthesis and processing of chromogranins in organotypic slices: influence of depolarization, forskolin and differentiating factors. Eur. J. Neurosci. 12, 2746-2756.

Collins J.J., Wilson K., Fischer-Colbrie R., and Papka R.E. (2000) Distribution and origin of secretoneurin-immunoreactive nerves in the female rat uterus. Neuroscience 95, 255-264.

Ekonomou A., Sperk G., Kostopoulos G., and Angelatou F. (2000) Reduction of A1 adenosine receptors in rat hippocampus after kainic acid-induced limbic seizures. Neurosci. Lett. 284, 49-52.

Ischia R., Hobisch A., Bauer R., Weiss U., Gasser R.W., Horninger W., Bartsch G., Jr., Fuchs D., Bartsch G., Winkler H., Klocker H., Fischer-Colbrie R., and Culig Z. (2000) Elevated levels of serum secretoneurin in patients with therapy resistant carcinoma of the prostate. J Urol 163, 1161-1164.

Ischia R., Gasser R.W., Fischer-Colbrie R., Eder U., Pagani A., Cubeddu L.X., Lovisetti-Scamihorn P., Finkenstedt G., Laslop A., and Winkler H. (2000) Levels and molecular properties of secretoneurin-immunoreactivity in the serum and urine of control and neuroendocrine tumor patients. J Clin Endocrinol Metab 85, 355-360.

Kähler C.M. and Fischer-Colbrie R. (2000) Secretoneurin - a novel link between the nervous and the immune system. Conservation of the sequence and functional aspects. Adv Exp Med Biol 482, 279-290.

Kandlhofer S., Hoertnagl B., Czech T., Baumgartner C., Maier H., Novak K., and Sperk G. (2000) Chromogranins in temporal lobe epilepsy. Epilepsia 41, S111-114.

Kato A., Kammen-Jolly K., Fischer-Colbrie R., Humpel C., Schrott-Fischer A., and Marksteiner J. (2000) Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem. Brain Res 852, 444-452.

Laslop A., Doblinger A., and Weiss U. (2000) Proteolytic processing of chromogranins. Adv Exp Med Biol 482, 155-166.

Pirker S., Schwarzer C., Wieselthaler A., Sieghart W., and Sperk G. (2000) GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101, 815-850.

Szabo G., Kartarova Z., Hoertnagl B., Somogyi R., and Sperk G. (2000) Differential regulation of adult and embryonic glutamate decarboxylases in rat dentate granule cells after kainate-induced limbic seizures. Neuroscience 100, 287-295.

Takahashi Y., Tsunashima K., Sadamatsu M., Schwarzer C., Amano S., Ihara N., Sasa M., Kato N., and Sperk G. (2000) Altered hippocampal expression of neuropeptide Y, somatostatin, and glutamate decarboxylase in Ihara's epileptic rats and spontaneously epileptic rats. Neurosci. Lett. 287, 105-108.

Vezzani A., Moneta D., Conti M., Richichi C., Ravizza T., De Luigi A., De Simoni M.G., Sperk G., Andell-Jonsson S., Lundkvist J., Iverfeldt K., and Bartfai T. (2000) Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc Natl Acad Sci U S A 97, 11534-11539.

Weiss U., Ischia R., Eder S., Lovisetti-Scamihorn P., Bauer R., and Fischer-Colbrie R. (2000) Neuroendocrine Secretory Protein 55 (NESP55): Alternative splicing onto transcripts of the GNAS gene and posttranslational processing of a maternally expressed protein. Neuroendocrinology 71, 177-186.


Bauer R., Ischia R., Marksteiner J., Kapeller I., and Fischer-Colbrie R. (1999) Localization of neuroendocrine secretory protein 55 messenger RNA in the rat brain. Neuroscience 91, 685-694.

Bauer R., Weiss C., Marksteiner J., Doblinger A., Fischer-Colbrie R., and Laslop A. (1999) The new chromogranin-like protein NESP55 is preferentially localized in adrenaline-synthesizing cells of the bovine and rat adrenal medulla. Neurosci Lett 263, 13-16.

Kähler C.M., Kaufmann G., Hogue-Angeletti R., Fischer-Colbrie R., Dunzendorfer S., Reinisch N., and Wiedermann C.J. (1999) A soluble gradient of the neuropeptide secretoneurin promotes the transendothelial migration of monocytes in vitro. Eur J Pharmacol 365, 65-75.

Leitner B., LovisettiScamihorn P., Heilmann J., Striessnig J., Blakely R.D., Eiden L.E., and Winkler H. (1999) Subcellular localization of chromogranins, calcium channels, amine carriers, and proteins of the exocytotic machinery in bovine splenic nerve. J Neurochem 72, 1110-1116.

Li J.Y., Leitner B., Lovisetti-Scamihorn P., Winkler H., and Dahlström A. (1999) Proteolytic processing, axonal transport and differential distribution of chromogranins A and B, and secretogranin II (secretoneurin) in rat sciatic nerve and spinal cord. Eur J Neurosci 11, 528-544.

Liang F., Li J.-Y., Lovisetti-Scamihorn P., Coen E., Depreitere J., Claeys M., Wechsung E., Dahlström A., Winkler H., and De Potter W.P. (1999) The processing of secretogranin II in the peripheral nervous system: release of secretoneurin from porcine sympathetic nerve terminals. Brain Res 818, 459-467.

Lovisetti-Scamihorn P., Fischer-Colbrie R., Leitner B., Scherzer G., and Winkler H. (1999) Relative amounts and molecular forms of NESP55 in various bovine tissues. Brain Res 829, 99-106.

Lovisetti-Scamihorn P., Liang F., Leitner B., De Potter W., and Winkler H. (1999) Pig splenic nerve: peptides derived from chromogranins by proteolytic processing during axonal transport. Regul Peptides 79, 63-67.

Marksteiner J., Bauer R., Kaufmann W.A., Weiss E., Barnas U., and Maier H. (1999) PE-11, a peptide derived from chromogranin B, in the human brain. Neuroscience 91, 1155-1170.

Vezzani A., Sperk G., and Colmers W.F. (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci 22, 25-30.


Eder U., Fischer-Colbrie R., Kogner P., Leitner B., Bjellerup P., and Winkler H. (1998) Levels and molecular forms of chromogranins in human childhood neuroblastomas and ganglioneuromas. Neurosci Lett 253, 17-20.

Eder U., Leitner B., Kirchmair R., Pohl P., Jobst K.A., Smith A.D., Mally J., Benzer A., Riederer P., Reichmann H., Saria A., and Winkler H. (1998) Levels and proteolytic processing of chromogranin A and B and secretogranin II in cerebrospinal fluid in neurological diseases. J. Neural Transm. 105, 39-51.

Gobbi M., Gariboldi M., Piwko C., Hoyer D., Sperk G., and Vezzani A. (1998) Distinct changes in peptide YY binding to, and mRNA levels of, Y1 and Y2 receptors in the rat hippocampus associated with kindling epileptogenesis. J Neurochem 70, 1615-22.

Hörtnagl H., Groll-Knapp E., Khanakah G., Sperk G., and Bubna-Littitz H. (1998) Perception of species-specific vocalizations in rats: role of the cholinergic septo-hippocampal pathway and aging. Int. J. Dev. Neurosci. 16, 715-27.

Howes E. A., Hurst S., Laslop A. and Jones R. (1998) Cellular distribution and molecular heterogeneity of MAC393 antigen (clusterin, beta-chain) on the surface membrane of bull spermatozoa. Mol. Hum. Reprod. 4, 673-681.

Ischia R., Culig Z., Eder U., Bartsch G., Winkler H., Fischer-Colbrie R., and Klocker H. (1998) Presence of chromogranins and regulation of their synthesis and processing in a neuroendocrine prostate tumor cell line. Prostate 8, 80-87.

Kaufmann W.A., Barnas U., Humpel C., Nowakowski K., DeCol C., Gurka P., Ransmayr G., Hinterhuber H., Winkler H., and Marksteiner J. (1998) Synaptic loss reflected by secretoneurin-like immunoreactivity in the human hippocampus in Alzheimer's disease. Eur. J. Neurosci. 10, 1084-1094.

Laslop A., Weiss C., Savaria D., Eiter C., Tooze S.A., Seidah N.G., and Winkler H. (1998) Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases. J. Neurochem. 70, 374-383.

Leitner B., Schneitler C., Klocker H., Volknandt W., Zimmermann H., Winkler H., and Fischer-Colbrie R. (1998) Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains. Neurosci. Lett. 248, 105-108. Abstract

Li J.Y., Leitner B., Winkler H., and Dahlström A. (1998) Distribution of chromogranins A and B and secretogranin II (secretoneurin) in rat pelvic neurons and vas deferens. Neuroscience 84, 281-294.

Prommegger R., Obrist P., Ensinger C., Schwelberger H.G., Wolf C., Fischer-Colbrie R., Mikuz G., and Bodner E. (1998) Secretoneurin in carcinoids of the appendix - immunohistochemical comparison with chromogranins A, B and secretogranin II. Anticancer Res 18, 3999-4002.

Sadamatsu M., Tsunashima K., Schwarzer C., Takahashi Y., Kato N., and Sperk G. (1998) Trimethyltin-induced expression of neuropeptide Y Y2 receptors in rat dentate gyrus. Neurotoxicol Teratol 20, 607-10.

Schneitler C., Kähler C., Wiedermann C.J., Hogue-Angeletti R., and Fischer-Colbrie R. (1998) Specific binding of a 125I-secretoneurin analogue to a human monocytic cell line. J. Neuroimmunol. 86, 87-91. Abstract

Schwarzer C., Auer B., Klima J. and Haselwandter K. (1998) Physiological and electron-microscopic investigations on syntrophic dicyandiamide degradation by soil bacteria. Soil Biol. & Biochem. 30, 385-391.

Schwarzer C., Kirchmair E., and Sperk G. (1998) Metabotropic glutamate receptors mediate activation of NPY-Y2 receptor expression in the rat dentate gyrus. Neuroreport 9, 2347-51.

Schwarzer C., Kofler N., and Sperk G. (1998) Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy. Mol Pharmacol 53, 6-13. Abstract

Schwarzer C. and Sperk G. (1998) Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors. Hippocampus 8, 274-88.

Sperk G., Schwarzer C., Tsunashima K., and Kandlhofer S. (1998) Expression of GABA(A) receptor subunits in the hippocampus of the rat after kainic acid-induced seizures. Epilepsy Res 32, 129-39.

Tsunashima K., Sadamatsu M., Takahashi Y., Kato N., and Sperk G. (1998) Trimethyltin intoxication induces marked changes in neuropeptide expression in the rat hippocampus. Synapse 29, 333-42.

Winkler H. and Fischer-Colbrie R. (1998) Regulation of the biosynthesis of large dense-core vesicles in chromaffin cells and neurons. Cell. Mol. Neurobiol. 18, 193-209.

Winkler H., Laslop A., Leitner B. and Weiss C. (1998) The secretory cocktail of adrenergic large dense-core vesicles: the functional role of the chromogranins. Adv. in Pharmacol. 42, 257-259.


Ang C.W., Dotman C.H., Winkler H., Fischer-Colbrie R., Sonnemans M.A.F., and VanLeeuwen F.W. (1997) Specific expression of secretogranin II in magnocellular vasopressin neurons of the rat supraoptic and paraventricular nucleus in response to osmotic stimulation. Brain Res. 765, 13-20.

Dun N.J., Dun S.L., Lin H.H., Hwang L.L., Saria A., and Fischer-Colbrie R. (1997) Secretoneurin-like immunoreactivity in rat sympathetic, enteric and sensory ganglia. Brain Res. 760, 8-16.

Eder U., Hukkanen M., Leitner B., Mur E., Went P., Kirchmair R., Fischer-Colbrie R., Polak J.M., and Winkler H. (1997) The presence of secretoneurin in human synovium and synovial fluid. Neurosci. Lett. 224, 139-141.

Ischia R., Lovisetti-Scamihorn P., Hogue-Angeletti R., Wolkersdorfer M., Winkler H., and Fischer-Colbrie R. (1997) Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity. J. Biol. Chem. 272, 11657-11662. Abstract

Kähler C.M., Kirchmair R., Kaufmann G., Kähler S.T., Reinisch N., Fischer-Colbrie R., Hogue-Angeletti R., Winkler H., and Wiedermann C.J. (1997) Inhibition of proliferation and stimulation of migration of endothelial cells by secretoneurin in vitro. Arterioscler. Thromb. Vasc. Biol. 17, 932-939.

Koch R.O., Wanner S.G., Koschak A., Hanner M., Schwarzer C., Kaczorowski G.J., Slaughter R.S., Garcia M.L., and Knaus H.G. (1997) Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology. J Biol Chem 272, 27577-81.

Kofler N., Kirchmair E., Schwarzer C., and Sperk G. (1997) Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats. Neurosci Lett 230, 129-32.

Kroesen S., Lang S., Fischer-Colbrie R., and Klimaschewski L. (1997) Plasticity of neuropeptide Y in the rat superior cervical ganglion in response to nerve lesion. Neuroscience 78, 251-258.

Leitner B., Kaufmann W.A., Marksteiner J., Hoflehner J., Traurig H., Saria A., Fischer-Colbrie R., and Winkler H. (1997) Ontogenic development of secretogranin II and of its processing to secretoneurin in rat brain. Dev. Brain Res. 100, 161-168.

Prommegger R., Marksteiner J., Wetscher G., Tschmelitsch J., Eder U., Fischer-Colbrie R., Saria A., and Bodner E. (1997) Obstructive ileus of large bowel is associated with low tissue levels of neuropeptides in prestenotic bowel segment. Dig. Dis. Sci. 42, 1513-1518.

Saria A., Kaufmann W.A., Marksteiner J., Leitner B., Traurig H., Fischer-Colbrie R., and Winkler H. (1997) Distribution and processing of secretoneurin in the developing rat brain. Ann N Y Acad Sci 814, 90-6.

Schratzberger P., Reinisch N., Prodinger W.M., Kähler C.M., Sitte B.A., Bellmann R., Fischer-Colbrie R., Winkler H., and Wiedermann C.J. (1997) Differential chemotactic activities of sensory neuropeptides for human peripheral blood mononuclear cells. J. Immunol. 158, 3895-3901.

Schwarzer C., Marksteiner J., Kroesen S., Kohl C., Sperk G., and Winkler H. (1997) Secretoneurin: a marker in rat hippocampal pathways. J Comp Neurol 377, 29-40.

Schwarzer C., Tsunashima K., Wanzenböck C., Fuchs K., Sieghart W., and Sperk G. (1997) GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience 80, 1001-1017. Abstract

Simonneaux V., Vuillez P., Eder U., Miguez J.M., Pevet P., and Fischer-Colbrie R. (1997) Secretoneurin: A new neuropeptide in the rodent pineal gland. Cell Tissue Res. 288, 427-434.

Sperk G. and Herzog H. (1997) Anticonvulsant action of neuropeptide Y. Neuropeptide Y may act as an endogenous anticonvulsant through Y5 receptors suggesting a new target for antiepileptic drugs [news; comment]. Nat Med 3, 728-9.

Sperk G., Schwarzer C., Tsunashima K., Fuchs K., and Sieghart W. (1997) GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience 80, 987-1000. Abstract

Tsunashima K., Schwarzer C., Kirchmair E., Sieghart W., and Sperk G. (1997) GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy. Neuroscience 80, 1019-1032. Abstract

Tsunashima K., Wolkersdorfer M., Schwarzer C., Sperk G., and Fischer-Colbrie R. (1997) Limbic seizures induce neuropeptide and chromogranin mRNA expression in rat adrenal medulla. Mol. Brain Res. 51, 42-48.

Winkler H. (1997) Membrane composition of adrenergic large and small dense cored vesicles and of synaptic vesicles: consequences for their biogenesis. Neurochem. Res. 22, 921-932.


Klimaschewski L., Kroesen S., Eder U., Leitner B., and Fischer-Colbrie R. (1996) Localization and axotomy-induced regulation of the peptide secretoneurin in the rat superior cervical ganglion. Eur. J. Neurosci. 8, 1953-1964.

Knaus H.G., Schwarzer C., Koch R.O., Eberhart A., Kaczorowski G.J., Glossmann H., Wunder F., Pongs O., Garcia M.L., and Sperk G. (1996) Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals. J Neurosci 16, 955-63.

Kroesen S., Marksteiner J., Leitner B., Hogue-Angeletti R., Fischer-Colbrie R., and Winkler H. (1996) Rat brain: Distribution of immunoreactivity of PE-11, a peptide derived from chromogranin B. Eur. J. Neurosci. 8, 2679-2689.

Leitner B., Fischer-Colbrie R., Scherzer G., and Winkler H. (1996) Secretogranin II: relative amounts and processing to secretoneurin in various rat tissues. J. Neurochem. 66, 1312-1317.

Miller C., Kirchmair R., Troger J., Saria A., Fleischhacker W.W., Fischer-Colbrie R., Benzer A., and Winkler H. (1996) CSF of neuroleptic-naive first-episode schizophrenic patients: levels of biogenic amines, substance P, and peptides derived from chromogranin A (GE-25) and secretogranin II (secretoneurin). Biol. Psych. 39, 911-918.

Nakic M., Mitrovic N., Sperk G., and Schachner M. (1996) Kainic acid activates transient expression of tenascin-C in the adult rat hippocampus. J Neurosci Res 44, 355-62.

Overdick B., Kirchmair R., Marksteiner J., Fischer-Colbrie R., Troger J., Winkler H., and Saria A. (1996) Presence and distribution of a new neuropeptide, secretoneurin, in human retina. Peptides 17, 1-4.

Röder C., Schwarzer C., Vezzani A., Gobbi M., Mennini T., and Sperk G. (1996) Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures. Neuroscience 70, 47-55. Abstract

Schwarzer C., Sperk G., Rauca C., and Pohle W. (1996) Neuropeptide Y and somatostatin immunoreactivity in the rat hippocampus after moderate hypoxia. Naunyn Schmiedebergs Arch Pharmacol 354, 67-71.

Schwarzer C., Sperk G., Samanin R., Rizzi M., Gariboldi M., and Vezzani A. (1996) Neuropeptides-immunoreactivity and their mRNA expression in kindling: functional implications for limbic epileptogenesis. Brain Res Brain Res Rev 22, 27-50. Abstract

Sperk G., Bellmann R., Gruber B., Greber S., Marksteiner J., Röder C., and Rupp E. (1996) Neuropeptide Y expression in animal models of temporal lobe epilepsy. Epilepsy Res Suppl 12, 197-203.

Storch M.K., Fischer-Colbrie R., Smith T., Rinner W.A., Hickey W.F., Cuzner M.L., Winkler H., and Lassmann H. (1996) Co-localization of secretoneurin immunoreactivity and macrophage infiltration in the lesions of experimental autoimmune encephalomyelitis. Neuroscience 71, 885-893.

Vezzani A., Schwarzer C., Lothman E.W., Williamson J., and Sperk G. (1996) Functional changes in somatostatin and neuropeptide Y containing neurons in the rat hippocampus in chronic models of limbic seizures. Epilepsy Res 26, 267-79.

Weiss C., Cahill A.L., Laslop A., Fischer-Colbrie R., Perlman R.L., and Winkler H. (1996) Differences in the composition of chromaffin granules in adrenaline and noradrenaline containing cells of bovine adrenal medulla. Neurosci. Lett. 211, 29-32.

Wolkersdorfer M., Egger C., Laslop A., and Fischer-Colbrie R. (1996) Nicotine and prostaglandin E induce secretogranin II levels in bovine chromaffin cells. Mol. Brain Res. 38, 260-266.

Wolkersdorfer M., Laslop A., Lazure C., Fischer-Colbrie R., and Winkler H. (1996) Processing of chromogranins in chromaffin cell culture: effects of reserpine and a-methyl p-tyrosine. Biochem. J. 316, 953-958.

You Z.B., Saria A., Fischer-Colbrie R., Terenius L., Goiny M., and Herrera-Marschitz M. (1996) Effects of secretogranin II-derived peptides on the release of neurotransmitters monitored in the basal ganglia of the rat with in vivo microdialysis. Naunyn-Schmied. Arch. Pharmacol. 354, 717-724.


Agneter E., Sitte H.H., Stöckl-Hiesleitner S., Fischer-Colbrie R., Winkler H., and Singer E.A. (1995) Sustained dopamine release induced by secretoneurin in the striatum of the rat: a microdialysis study. J. Neurochem. 65, 622-625.

Brinkschmidt C., Stolze P., Fahrenkamp A.G., Hundeiker M., Fischer-Colbrie R., Zelger B., Böcker W., and Schmid K.W. (1995) Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretoneurin in merkel cell carcinoma of the skin. Appl. Immunohistochem. 3, 37-44.

Fahrenkamp A.G., Wibbeke C., Winde G., Öfner D., Böcker W., Fischer-Colbrie R., and Schmid K.W. (1995) Immunohistochemical distribution of chromogranins A and B and secretogranin II in neuroendocrine tumours of the gastrointestinal tract. Virchows Arch. 426, 361-367.

Fischer-Colbrie R., Laslop A., and Kirchmair R. (1995) Secretogranin II: molecular properties, regulation of biosynthesis and processing to the neuropeptide secretoneurin. Prog. Neurobiol. 46, 49-70.

Hoflehner J., Eder U., Laslop A., Seidah N.G., Fischer-Colbrie R., and Winkler H. (1995) Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin. FEBS Lett. 360, 294-298.

Kirchmair R., Leitner B., Fischer-Colbrie R., Marksteiner J., Hogue-Angeletti R., and Winkler H. (1995) Large variations in the proteolytic formation of a chromogranin A-derived peptide (GE-25) in neuroendocrine tissues. Biochem. J. 310, 331-336.

Klimaschewski L., Benndorf K., Kirchmair R., Fischer-Colbrie R., and Heym C. (1995) Secretoneurin-immunoreactivity in nerve terminals apposing identified preganglionic sympathetic neurons in the rat: colocalization with substance P and enkephalin. J. Chem. Neuroanat. 9, 55-63.

Kroesen S., Marksteiner J., Mahata S.K., Mahata M., Fischer-Colbrie R., Saria A., Kapeller I., and Winkler H. (1995) Effects of haloperidol, clozapine and citalopram on messenger RNA levels of chromogranins A and B and secretogranin II in various regions of rat brain. Neuroscience 69, 881-891.

Lang S. and Sperk G. (1995) Neurochemical characterization of preprotachykinin B(50-79) immunoreactivity in the rat. Regul Pept 57, 183-92.

Marksteiner J., Lassnig E., Telser S., Kroesen S., Kirchmair R., Fischer-Colbrie R., Miller C., and Saria A. (1995) Evidence for a high density of secretoneurin-like immunoreactivity in the extended amygdala of the rat. J. Comp. Neurol. 353, 275-290.

Pagani A., Fischer-Colbrie R., Eder U., Pellin A., Llombart-Bosch A., and Bussolati G. (1995) Neural and mesenchymal differentiations in Ewing's sarcoma cell lines. Morphological, immunophenotypic, molecular biological and cytogenetic evidence. Int J Cancer 63, 738-43.

Schmid K.W., Kunk B., Kirchmair R., Tötsch M., Böcker W., and Fischer-Colbrie R. (1995) Immunohistochemical detection of secretoneurin, a novel neuropeptide endoproteolytically processed from secretogranin II, in normal human endocrine and neuronal tissues. Histochem. J. 27, 473-481.

Schmid K.W., Morgan J.M., Baumert M., Fischer-Colbrie R., Böcker W., and Jasani B. (1995) Calcitonin and calcitonin gene-related peptide mRNA detection in a population of hyperplastic parathyroid cells also expressing chromogranin B. Lab. Invest. 73, 90-95.

Schürmann G., Bishop A.E., Facer P., Eder U., Fischer-Colbrie R., Winkler H., and Polak J.M. (1995) Secretoneurin: a new peptide in the human enteric nervous system. Histochem. Cell Biol. 104, 11-19.

Schwarzer C. and Sperk G. (1995) Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat. Neuroscience 69, 705-9.

Schwarzer C., Williamson J.M., Lothman E.W., Vezzani A., and Sperk G. (1995) Somatostatin, neuropeptide Y, neurokinin B and cholecystokinin immunoreactivity in two chronic models of temporal lobe epilepsy. Neuroscience 69, 831-45.

Tötsch M., Padberg B.C., Schröder S., Öfner D., Böcker W., Fischer-Colbrie R., and Schmid K.W. (1995) Secretoneurin in bronchopulmonary carcinoids - immunohistochemical comparison with chromogranins A and B and secretogranin II. Histopathology 26, 357-361.

Tschernitz C., Laslop A., Eiter C., Kroesen S., and Winkler H. (1995) Biosynthesis of large dense-core vesicles in PC12 cells: effects of depolarization and second messengers on the mRNA levels of their constituents. Mol. Brain Res. 31, 131-140.


Selected previous publications

Karobath M, Sperk G (1979) Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid. Proc. Natl. Acad. Sci. (USA) 76, 1004-1006.

Cohn D.V., Zangerle R., Fischer-Colbrie R., Chu L.L.H., Elting J.J., Hamilton J.W., and Winkler H. (1982) Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla. Proc. Natl. Acad. Sci. USA 79, 6056-6059. Abstract

Sperk G. (1982) Simultaneous determination of serotonin, 5-hydroxyindoleacetic acid, 3,4-dihydroxyphenylacetic acid andhomovanillic acid by high performance liquid chromatography with electrochemical detection. J. Neurochem. 38, 840-843.

Lingg G., Fischer-Colbrie R., Schmidt W., and Winkler H. (1983) Exposure of an antigen of chromaffin granules on cell surface during exocytosis. Nature (Lond.) 301, 610-611.

Sperk G, Lassmann H, Baran H, Kish SJ, Seitelberger F, Hornykiewicz O (1983) Kainic acid induced seizures: Neurochemical and histopathological changes. Neuroscience 10, 1301-1315.

Patzak A., Böck G., Fischer-Colbrie R., Schauenstein K., Schmidt W., Lingg G., and Winkler H. (1984) Exocytotic exposure and retrieval of membrane antigens of chromaffin granules: quantitative evaluation of immunofluorescence on thesurface of chromaffin cells. J. Cell Biol. 98, 1817-1824.

Fischer-Colbrie R. and Frischenschlager I. (1985) Immunological characterization of secretory proteins of chromaffin granules: chromogranins A, chromogranins B and enkephalin-containing peptides. J. Neurochem. 44, 1854-1861.

Winkler H., Apps D.K., and Fischer-Colbrie R. (1986) The molecular function of adrenal chromaffin granules: established facts and unresolved topics. Neuroscience 18, 261-290.

Hagn C., Schmidt K.W., Fischer-Colbrie R., and Winkler H. (1986) Chromogranin A, B and C in human adrenal medulla and endocrine tissues. Lab. Invest. 55, 405-411.Schober M., Fischer-Colbrie R., Schmid K.W., Busollati G., O'Connor D.T., and Winkler H. (1987) Comparison of chromogranins A, B and secretogranin II in human adrenal medulla and pheochromocytoma. Lab. Invest. 57, 385-391.

Iacangelo A.L., Fischer-Colbrie R., Koller K.J., Brownstein M.J. and Eiden L.E. (1988) The sequence of porcine chromogranin A messenger RNA demonstrates that chromogranin A can serve as the precursor for the biologically active hormone, pancreastatin. Endocrinology 122, 2339-2341.

Fischer-Colbrie R., Iacangelo A., and Eiden L.E. (1988) Neural and humoral factors separately regulate neuropeptide Y, enkephalin and chromogranin A and B mRNA levels in rat adrenal medulla. Proc. Natl. Acad. Sci. USA 85, 3240-3244.Marksteiner J. and Sperk G. (1988) Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold. Neuroscience 26, 379-385. Abstract

Olenik C., Meyer D. K., Marksteiner J. and Sperk G. (1989) Concentrations of mRNAs encoding for preprosomatostatin and preprocholecystokinin are increased after kainic acid induced seizures. Synapse 4, 223-228. Abstract

Fischer-Colbrie R., Gutierrez J., Hsu C.-M., Iacangelo A., and Eiden L.E. (1990) Sequence analysis, tissue distribution and regulation by cell depolarization and second-messengers of bovine secretogranin II (chromogranin C) mRNA. J. Biol. Chem. 265, 9208-9213.Winkler H. and Fischer-Colbrie R. (1990) Common membrane proteins of chromaffin granules, endocrine and synaptic vesicles: properties, tissue distribution, membrane topography and regulation of synthesis. Neurochem. Int. 17, 245-262.

Weiler R., Marksteiner J., Bellmann R., Wohlfarter T., Schober M., Fischer-Colbrie R., Sperk G., and Winkler H. (1990) Chromogranins in rat brain: characterization, topographical distribution and regulation of synthesis. Brain Res. 532, 87-94.

Sperk G, Marksteiner J, Saria A, Humpel C (1990) Differential changes in tachykinins after kainic acid induced seizures in the rat. Neuroscience 34, 219-224.

Mahata S.K., Mahata M., Marksteiner J., Sperk G., Fischer-Colbrie R., and Winkler H. (1991) Distribution of mRNAs forchromogranins A and B and secretogranin II in rat brain. Europ. J. Neurosci. 3, 895-904.

Bellmann R., Widmann R., Olenik C., Meyer D. K., Maas D., Marksteiner J. and Sperk G. (1991) Enhanced rate of expression and biosynthesis of neuropeptide Y after kainic acid induced seizures. J. Neurochem. 56, 525-530. Abstract

Winkler H. and Fischer-Colbrie R. (1992) The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 49, 497-528.

Marksteiner J., Sperk G. and Krause J. E. (1992) Distribution of neurons expressing neurokinin B in the rat brain: Immunohistochemistry and in situ hybridization. J. Comp. Neurol. 317, 341-356. AbstractMarksteiner J., Wahler R., Bellmann R., Ortler M., Krause J. E. and Sperk G. (1992) Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat. Neuroscience 49, 383-395. Abstract

Sperk G., Marksteiner J., Gruber B., Bellmann R., Mahata M. and Ortler M. (1992) Functional changes in neuropeptide Y and somatostatin containing neurons induced by limbic seizures in the rat. Neuroscience 50, 831-846.

Bauer J.W., Kirchmair R., Egger C., and Fischer-Colbrie R. (1993) Histamine induces a gene-specific synthesis regulation of secretogranin II but not of chromogranin A and B in chromaffin cells in a calcium-dependent manner. J. Biol. Chem. 268, 1586-1589.Kirchmair R., Hogue-Angeletti R., Gutierrez J., Fischer-Colbrie R., and Winkler H. (1993) Secretoneurin - a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C). Neuroscience 53, 359-366. Abstract

Saria A., Troger J., Kirchmair R., Fischer-Colbrie R., Hogue-Angeletti R., and Winkler H. (1993) Secretoneurin releases dopamine from rat striatal slices: a biological effect of a peptide derived from secretogranin II (chromogranin C). Neuroscience 54, 1-4. Abstract

Marksteiner J., Kirchmair R., Mahata S.K., Mahata M., Fischer-Colbrie R., Hogue-Angeletti R., Saria A., and Winkler H.(1993) Distribution of secretoneurin, a peptide derived from secretogranin II, in rat brain. An immunocytochemical and radioimmunological study. Neuroscience 54, 923-944. Abstract

Laslop A., Steiner H.-J., Egger C., Wolkersdorfer M., Kapelari S., Hogue-Angeletti R., Erickson J.D., Fischer-Colbrie R., and Winkler H. (1993) Glycoprotein III (clusterin, sulfated glycoprotein 2) in endocrine, nervous and other tissues: immunochemical characterization, subcellular localization and regulation of biosynthesis. J. Neurochem. 61, 1498-1505.

Bellmann R. and Sperk G. (1993) Effects of antidepressant drug treatment on levels of NPY or prepro-NPY-mRNA in the rat brain. Neurochem. Int. 22, 183-187.Gruber B., Greber S. and Sperk G. (1993) Kainic acid seizures cause enhanced expression of cholecystokinin-octapeptide in the cortex and hippocampus of the rat. Synapse 15, 221-228.

Kirchmair R., Marksteiner J., Troger J., Mahata S.K., Mahata M., Donnerer J., Amman R., Fischer-Colbrie R., Winkler H. and Saria A. (1994) Human and rat primary C-fibre afferents store and release secretoneurin, a novel neuropeptide. Europ. J. Neurosci. 6, 861-868. Abstract

Troger J., Kirchmair R., Marksteiner J., Seidl C.V., Fischer-Colbrie R., Saria A. and Winkler H. (1994) Release of secretoneurin and noradrenaline from hypothalamic slices and its differential inhibition by calcium channel blockers.Naunyn-Schmiedeberg's Arch. Pharmacol. 349, 565-569. Abstract

Marksteiner J., Mahata S.K., Pycha R., Mahata M., Saria A., Fischer-Colbrie R., and Winkler H. (1994) Distribution of secretoneurin-immunoreactivity in the spinal cord and lower brain stem in comparison with that of substance P and calcitonin gene related peptide. J. Comp. Neurol. 340, 243-254.

Laslop A., Mahata S.K., Wolkersdorfer M., Mahata M., Srivastava M., Seidah N.G., Fischer-Colbrie R. and Winkler H. (1994) Large dense core vesicles in rat adrenal after reserpine: levels of mRNAs of soluble and membrane-bound constituents in chromaffin and ganglion cells indicate a biosynthesis of vesicles with higher secretory quanta. J. Neurochem.62, 2448-2456.

Kirchmair R., Benzer A., Troger J., Miller C., Marksteiner J., Saria A., Gasser R.W., Hogue-Angeletti R.H., Fischer-Colbrie R. and Winkler H. (1994) Molecular characterisation of immunoreactivities of peptides derived from chromogranin A (GE-25) and from secretogranin II (secretoneurin) in human and bovine cerebrospinal fluid. Neuroscience 63, 1179-1187.

Greber S., Schwarzer C. and Sperk G. (1994) Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro. Br. J. Pharmacol.113, 737-740. Abstract

Gruber B., Greber S., Rupp E. and Sperk G. (1994) Differential NPY mRNA expression in granule cells and interneuronsof the rat dentate gyrus after kainic acid injection. Hippocampus 4, 474-482.

Sperk G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol. 42, 1-32.



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