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Research Interest 

Structure & Function of Chromatin: filamentous fungi

gerald_brosch

In eukaryotic cells, the readout of the genetic information is significantly controlled by structural changes of chromatin. Covalent modifications of DNA and core-histone proteins, the building blocks of nucleosomes, are primarily responsible for genome-wide or localized chromatin alterations. In response to cellular or environmental signals, these modifications affect a variety of regulatory processes during growth, differentiation and development, metabolism, diseases, and abiotic and biotic stress.stefan_graessle

Within the last decade, we have deleted numerous histone modifying enzymes in pathogenic and non-pathogenic filamentous fungi and have analyzed the corresponding mutants with regard to pathogenicity, production of fungal metabolites and fitness under different growth conditions.

Whereas some deletions show only negligible effects, others significantly impact viability, production of important secondary metabolites such as antibiotics and toxins or affect pathogenicity of causative fungi. A further characterization of histone modifying enzymes and the elucidation of their roles as regulators of metabolites, as virulence factors or targets of antifungal substances more...
Group Brosch / Grässle

Antifungal Therapeutics and Resistance

fabio_gsaller

Annually, more than 1.5 million people die as result of fungal infections. Around one third of deaths are caused by the genus Aspergillus, in particular, the major human mold pathogen Aspergillus fumigatus

Fungi as well as mammals belong to the domain of eukaryotes and vital processes in mammalian cells are also conserved in fungal species. Therefore, substances with antifungal activity often have toxic effects on human cells, which makes it particularly challenging more...
Group Gsaller

Molecular Microbiology

hubertus_haasFungi affect the life of mankind positively and negatively. On the one hand, fungi are major players in saprobic decomposition, mutually interact with plants (mycorrhiza), serve directly as food (mushrooms) or in food production (e.g., bread, cheese, alcohol), and produce widely used primary (e.g. citrate, enzymes) and secondary metabolites (e.g. penicillin, cyclosporine A). On the other hand, some fungi are pathogens of plants (e.g. Fusarium spp.) and animals more...
Group Haas

Structure and Function of chromatin: Maize & Mouse

peter_loidl

Chromatin represents a complex structure basically built from repeating units, the nucleosomes. These consist of DNA wrapped around an octamer of the core histones. The octamer is formed by 2 molecules each of histones H2A, H2B, H3, and H4. At least 2 different domains can be distinguished in core histones, a globular domain involved in histone-histone interactions (containing the histone fold motif) and the flexible N-terminal tails (of H3 and H4) or N-terminal and more...
Group Loidl

Chromatin- and Epigenetics

Alexandra_Lusser

The way in which eukaryotic DNA is organized in chromatin has profound effects on all processes that direct DNA metabolism (such as transcription, replication, repair and recombination). Chromatin controls access to the DNA, and it harbors epigenetic information. We are interested to learn about the establishment, maintenance and modification of eukaryotic chromatin structure. We are approaching this question by studying the molecular mechanisms and biological context more...
Group Lusser

Applied Mycology

florentine_marx_ladurnerFilamentous fungi secrete a wide array of different proteins into the external medium where they accomplish the most diverse functions, e.g. assimilation of complex nutrients, communication between other fungal cells, interaction between pathogenic fungi and their host; apart from some secreted enzymes which have been developed for a variety of commercial uses (mainly for the fermentation industry) only few extracellular proteins are well characterized in respect to more...
Group Marx-Ladurner

Lipocalin laboratory

bernhard_redlThe protein superfamily of lipocalins consists of small, mainly secretory proteins defined on the basis of conserved amino acid sequence motifs and their common structure. Functionally, they were found to be important extracellular carriers of lipophilic compounds in vertebrates, invertebrates, plants, and bacteria. There is increasing evidence that this group of proteins is involved in a variety of physiological processes including retinoid, fatty acid and pheromone more...
Group Redl

Publications of the Institute of Molecular Biology

Institut für Molekularbiologie