Bioprinting

Publications:

 

Book Chapters

Ausserlechner, M. J., Hagenbuchner, J., Fuchs, S., Geiger, K,. and Obexer, P. 2011. FOXO transcription factors as potential therapeutic targets in neuroblastoma, pp. 325-348 In H. Shimada [ed.], Neuroblastoma - Present and Future. InTech, Rijeka, Croatia. Link

Obexer, P., Hagenbuchner, J., Holzner, M., and Ausserlechner, M. J. 2011. p16INK4A - connecting cell cycle control to cell death regulation in human leukemia, pp. 115-130 In O. Babusikova, S. Dovat, and K. S. Payne [eds.], T-cell Leukemia. InTech, Rijeka, Croatia. Link

 

Original Articles (peer reviewed):

 

Hagenbuchner J., Scholl-Buergi, S., Karall, D., Ausserlechner, M.J. (2018) Very long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery. Scientific Reports 19;8(1):3254. doi: 10.1038/s41598-018-21519-2. PubMed

 

Rupp M.*, Hagenbuchner J.*, Rass B., Fiegl H., Kiechl-Kohlendorfer U., Obexer P., Ausserlechner M.J. (2017) FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3. Oncogene. 36(44): 6190-6203. doi: 10.1038/onc.2017.288. PubMed

 

Salcher S., Hermann M., Kiechl-Kohlendorfer U., Ausserlechner M.J., Obexer P. (2017) C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. Mol Cancer. 16(1):95. doi: 10.1186/s12943-017-0661-4. PubMed

 

Hagenbuchner, J., Lungkofler, L., Kiechl-Kohlendorfer, U., Viola, G., Ferlin, M.G., Ausserlechner, M.J., Obexer, P. (2017) The tubulin-inhibitor MG-2477 induces autophagy-regulated cell death and activation of FOXO3 in neuroblastoma. Oncotarget, 8(19):32009-32026. PubMed

 

Hagenbuchner, J., Rupp, M., Salvador, C., Meister, B.,  Kiechl-Kohlendorfer, U., Thomas Müller, T., Geiger, K., Sergi, C., Obexer, P., Ausserlechner, M.J. (2016) Nuclear FOXO3 predicts adverse clinical outcome and promotes tumorangiogenesis in neuroblastoma in vivo. Oncotarget, 7(47):77591-77606. doi: 10.18632/oncotarget.12728. PubMed

 

Hagenbuchner J., Kiechl-Kohlendorfer U., Obexer P., Ausserlechner M.J. (2016) BIRC5/Survivin as target for glycolysis inhibition in high-stage neuroblastoma. Oncogene, 35(16):2052-61. doi: 10.1038/onc.2015.264. PubMed

 

Schäfer S, Salcher S, Seiter M, Ranninger C, Möst M, Obexer P, Huber CG, Ausserlechner M.J., Schwaiger S, Stuppner H (2016). Characterization of the XIAP-Inhibiting Proanthocyanidin Fraction of the Aerial Parts of Ephedra sinica. Planta Med. 82(11-12):973-85. doi: 10.1055/s-0042-107253. PubMed

 

Hagenbuchner J., and Ausserlechner M.J. (2016). Transcription factors as drug targets for small chemical compounds. Biochemical Pharmacology, 107:1-13. doi: 10.1016/j.bcp.2015.12.006 PubMed

 

Ausserlechner M.J., Hagenbuchner J. Mitochondrial survivin – an Achilles’ heel in cancer chemoresistance (2015). Molecular and Cellular Oncology, (invited Author’s view), 29;3(2):e1076589. doi: 10.1080/23723556.2015.1076589. PubMed

 

Salcher S, Hagenbuchner J, Geiger K, Seiter M.A, Rainer J, Kofler R, Hermann M, Kiechl-Kohlendorfer U, Ausserlechner M.J. Obexer P., (2014). C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma, Mol Cancer. 13(1):224. PubMed

 

Seiter M., Salcher S., Rupp M., Hagenbuchner J., Kiechl-Kohlendorfer U., Mortiere J., Wolber G., Rollinger JM., Obexer P., Ausserlechner M.J.  (2014) Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP), FEBS open bio, 4, 659. PubMed

 

Obexer, P., Ausserlechner, M.J. (2014) X-linked inhibitor of apoptosis (XIAP) – a critical death-resistance regulator and therapeutic target for personalized cancer therapy. Frontiers in Oncology, Jul 28;4:197. PubMed

 

Hagenbuchner,J. and Ausserlechner,M.J. (2013) Mitochondria and FOXO3: breath or die. Frontiers in Physiology., 4:147. PubMed

 

Hagenbuchner,J., Kiechl-Kohlendorfer,U., Obexer,P. and Ausserlechner,M.J. (2013) A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration. Oncotarget. ;4(8):1241-52. PubMed

 

Ausserlechner,M.J., Salvador,C., Deutschmann,A., Bodner,M., Viola,G., Bortolozzi,R., Basso,G., Hagenbuchner,J. and Obexer,P. (2013) Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa. Oncotarget, 4(7): 995- 1007. PubMed 

 

Hagenbuchner J, Kuznetsov AV, Obexer P, and Ausserlechner MJ (2013). BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery, Oncogene, 32(40):4748-57. PubMed

 

Geiger, K.*, Hagenbuchner, J.*, Rupp, M., Fiegl, H., Sergi, C., Meister, B., Kiechl-Kohlendorfer, U., Müller, T., Michael J. Ausserlechner, M.J. , Obexer, P. (2012). FOXO3/FKHRL1 is activated by 5-Aza-2-deoxycytidine (5-azadC) and induces silenced Caspase-8 in neuroblastoma. Molecular Biology of the Cell, 23(11): 2226-34. PubMed

 

Hagenbuchner, J., Kuznetsov, A. V., Hermann, M., Hausott, B., Obexer, P., Ausserlechner, M. J. (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11/Bim and SESN3. Journal of Cell Science. 125(PT5): 1191-203. PubMed 

 

Hagenbuchner, J., Ausserlechner, MJ., Porto, V., David, R., Meister, B., Bodner, M., Villunger, A., Geiger, K., Obexer, P. (2010) The Antiapoptotic Protein BCL2L1/BCL-XL is Neutralized by Proapoptotic PMAIP1/Noxa in Neuroblastoma Thereby Determining Bortezomib-Sensitivity Independent of Prosurvival MCL1 Expression. Journal of Biological Chemistry. 285(10):6904-12. PubMed

 

Berger, R., Fiegl, H., Goebel, G., Obexer, P., Ausserlechner, MJ., Doppler, W., Hauser-Kronberger, C., Reitsamer, R., Egle, D., Reimer, D., Müller-Holzner, E., Jones, A., Widschwendter, M. (2010) Toll-like Receptor-9 expression in breast and ovarian cancer is associated with poorly differentiated tumors. Cancer Science, 101(4):1059-66. PubMed 

 

Tominaga, K., Tominaga, E., Ausserlechner, MJ., Pereira-Smith, OM. (2010) The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway. Experimental Cell Research. 360(1): 92-102. PubMed

 

Obexer, P., Hagenbuchner, J., Rupp, M., Salvador, C., Holzner, M., Deutsch, M., Porto, V., Kofler, R., Unterkircher, T., Ausserlechner, MJ. (2009) p16INK4Asensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. Journal of Biological Chemistry. 284(45): 30933-40. PubMed

 

Obexer, P., Hagenbuchner, J., Unterkircher, T., Sachsenmaier, N., Seifarth, C., Böck, G., Porto, V., Geiger,  K., Ausserlechner, MJ. (2009) Repression of BIRC5/Survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA-damage-induced apoptosis.  Molecular Biology of the Cell,20(7), 2041-48. PubMed

 

Prelog M, Schwarzenbrunner N, Sailer-Höck M, Kern H, Klein-Franke A, Ausserlechner MJ, Koppelstaetter C, Brunner A, Duftner C, Dejaco C, Strasak AM, Müller T, Zimmerhackl LB, Brunner J. (2008) Premature aging of the immune system in children with juvenile idiopathic arthritis. Arthritis and Rheumatism, 58(7):2153-62. PubMed

 

Spoden GA, Mazurek S, Morandell D, Bacher N, Ausserlechner MJ, Jansen-Dürr P, Eigenbrodt E, Zwerschke W. (2008) Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation., International Journal of  Cancer. 123(2):312-21. PubMed

 

Obexer, P., Geiger, K., Ambros, P., Meister, B., Ausserlechner, M.J. (2007) FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death and Differentiation, 14(3), 534-547. PubMed

 

Ausserlechner, M.J., Obexer, P., Geiger, K., Deutschmann, A., Kofler, R. (2006) A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of anti-proliferative and toxic genes  Molecular Cancer Therapeutics, 5(8), 1927-34. PubMed 

 

Agu, C.A., Klein, R., Schwab, S., Konig-Schwab, M., Kodajova, P., Ausserlechner, M. J., Binishofer, B., Blasi, U., Salmons, B., Günzburg, W. H., Hohenadl, C. (2006): The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models. Journal of Gene Medicine. 8(2), 229-241. PubMed

 

Bacher, N., Tiefenthaler, M., Sturm, S., Stuppner, H., Ausserlechner, M. J., Kofler, R., Konwalinka, G. (2006): Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2 expressing acute lymphoblastic leukaemia cells. British Journal of Haematatology. 132(5), 615-622. PubMed

 

Prelog, M., Bergmann, C., Ausserlechner, M.J., Fischer, H., Margreiter, R., Gassner, I., Brunner, A., Jungraithmayr, T.C., Zerres, K., Sergi, E.C. Zimmerhackl, L.B. (2006) Successful transplantation in a child with rapid progression of autosomal recessive polycystic kidney disease associated with a novel mutation. Pediatric  Transplantation. 10:362-366. PubMed

Ausserlechner, M. J., Obexer, P., Geley, S., Kofler, R. (2005): G1-arrest by p16INK4A Uncouples Growth from Cell Cycle Progression in Leukemic Cells with Deregulated Cyclin E and c-Myc. Leukemia, 19(6), 1051-1057. PubMed

 

Ausserlechner, M. J., Obexer, P., Böck, G., Geley, S., and Kofler, R. (2004): Cyclin D3 and c-Myc Control Glucocorticoid-induced Cell Cycle Arrest but not Apoptosis in Lymphoblastic Leukemia Cells. Cell Death and Differentiation, 11(2), 165-174. PubMed

 

Riml, S., Schmidt, S., Ausserlechner, M.J., Geley, S., Kofler, R. (2004): Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells. Cell Death and Differentiation, 11(S1), 65-72. PubMed

 

Villunger, A., Michalak, E., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M.J., Adams, J.M., Strasser, A. (2003): BH3-only Proteins Puma/Bbc3 and Noxa Are Limiting for Cytotoxic Drug-Induced Apoptosis. Science, 302, 1036-1038. PubMed

 

Renner, K., Ausserlechner, M.J., Kofler, R. (2003). A Conceptual View on Gluco­corticoid-Induced Apoptosis, Cell Cycle Arrest and Glucocorticoid Resistance in Lymphoblastic Leukemia. Current Molecular Medicine, 3, 707-717. PubMed

 

Kofler, R., Schmidt, S., Kofler, A., Ausserlechner, M.J., (2003): Resistance to Glucocorticoid-induced Apoptosis in Lymphoblastic Leukemia.  Journal of Endocrinology, 178, 19-27. PubMed

 

Larcher, C., Bernhard, D., Schaad, E., Adler, B., Ausserlechner, M.J., Mitterer, M., Huemer, H.P. (2003): Functional Analysis of the Mutated Epstein-Barr Virus LMP1 Oncoprotein (LMP-69del) from a Case of Persistent Polyclonal B-cell Lymphocytosis. Haematologica, 88(12), 1324-1335. PubMed

 

Ausserlechner, M. J., Obexer, P., Wiegers, G. J., Hartmann, B. L., Geley, S., and Kofler, R. (2001): The Cell Cycle Inhibitor p16/Ink4a Sensitizes Lymphoblastic Leukemia Cells to Apoptosis by Physiologic Glucocorticoid Levels. Journal of Biological Chemistry. 276, 10984-10989. PubMed

 

Ruefli, A. A., Ausserlechner, M. J., Bernhard, D., Sutton, V. R., Tainton, K., Kofler, R., Smyth, M. J., Johnstone, R. W. (2001): The Histone Deacetylase Inhibitor and Chemotherapeutic Agent Suberoylanilide Hydroxamic Acid (SAHA) Induces a Cell-death Pathway Characterized by Cleavage of Bid and Production of Reactive Oxygen Species. PNAS, 18, 10833-10838. PubMed

 

Tonko, M., Ausserlechner, M. J., Bernhard, D., Helmberg, A., and Kofler, R. (2001): Gene Expression Profiling of Proliferating Versus G1/G0 Arrested Human Leukemia Cells Suggests a Mechanism For Glucocorticoid-induced Apoptosis. The FASEB Journal, 15, 693-699. PubMed 

 

Bernhard, D., Tinhofer, I, Tonko, M., Hübl, H, Ausserlechner, M. J., Greil, R, Kofler, R., and Csordas, A.(2000): Resveratrol Causes Arrest in the S-phase prior to Fas-independent Apoptosis in CEM-C7H2 Acute Leukemia Cells. Cell Death and Differentiation, 7, 834-842. PubMed

 

Bernhard, D., Ausserlechner, M. J., Tonko, M., Loffler, M., Hartmann, B. L., and Kofler, R. (1999): Apoptosis Induced by the Histone Deacetylase Inhibitor Butyrate in Human Leukemic Lymphoblasts. The FASEB Journal, 13, 1991-2001. PubMed

 

Löffler, M., Ausserlechner, M. J., Tonko, M., Hartmann, B. L., Bernhard, D., Geley, S., and Kofler, R. (1999): C-Myc Does Not Prevent Glucocorticoid-induced Apoptosis of Human Leukemic Lymphoblasts. Oncogene, 18, 4626-4631. PubMed

 

Ausserlechner, M. J., Sgonc, R., and Wick, G. (1998): Chemiluminescence-based RNase Protection Assays for Simultaneous Quantification of Procollagen mRNAs Containing AU Rich Regions. Biotechniques 24, 366-370. PubMed

 

Ausserlechner, M. J., Sgonc, R., Dietrich, H., and Wick, G. (1997): Altered Procollagen mRNA Expression during the Progression of Avian Scleroderma. Molecular Medicine 3, 654-662. PubMed

 

Geley, S., Hartmann, B. L., Hattmannstorfer, R., Löffler, M., Ausserlechner, M. J., Bernhard, D., Sgonc, R., Strasser-Wozak, E. M. C., Ebner, M., Auer, B., and Kofler, R. (1997): p53-induced Apoptosis in the Human T-ALL Cell Line CCRF-CEM. Oncogene 15, 2429-2437. PubMed

 

 

 

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