Koch, J., Lackner, K., Wohlfarter, Y., Sailer, S., Zschocke, J., Werner, E. R., Watschinger, K. & Keller, M. A. Unequivocal mapping of molecular ether lipid species by LC-MS/MS in plasmalogen-deficient mice. Analytical Chemistry (2020)

Gonzalez-Franquesa, A., Gama-Perez, P., Kulis, M., Dahdah, N., Moreno-Gomez, S., Latorre-Pellicer, A., Fernández-Ruiz, R., Monelli, E., Samino, S., Miró, J., Oemer, G., Duran, X., Sanchez-Rebordelo, E., Schneeberger, M., Montane, J., Castellano, G., Chapaprieta, V., Prieto, I., Castaño, C., et al. Obesity causes irreversible mitochondria failure in visceral adipose tissue despite successful anti-obesogenic lifestyle-based interventions 2 3 Affiliations. Jose Antonio Enríquez 16, 21 (2020).      

Mayr, L., Grabherr, F., Schwärzler, J., Reitmeier, I., Sommer, F., Gehmacher, T., Niederreiter, L., He, G. W., Ruder, B., Kunz, K. T. R., Tymoszuk, P., Hilbe, R., Haschka, D., Feistritzer, C., Gerner, R. R., Enrich, B., Przysiecki, N., Seifert, M., Keller, M. A., et al. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease. Nature Communications 11, 1–15 (2020).

Werner, E. R., Keller, M. A., Sailer, S., Lackner, K., Koch, J., Hermann, M., Coassin, S., Golderer, G., Werner-Felmayer, G., Zoeller, R. A., Hulo, N., Berger, J. & Watschinger, K. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proceedings of the National Academy of Sciences  201917461 (2020).

Michel, M., Dubowy, K.-O., Zlamy, M., Karall, D., Adam, M. G., Entenmann, A., Keller, M. A., Koch, J., Odri Komazec, I., Geiger, R., Salvador, C., Niederwanger, C., Müller, U., Scholl-Bürgi, S. & Laser, K. T. Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle. Therapeutic Advances in Chronic Disease 11, 204062232091603 (2020).

Oemer, G., Koch, J., Wohlfarter, Y., Alam, M. T., Lackner, K., Sailer, S., Neumann, L., Lindner, H. H., Watschinger, K., Haltmeier, M., Werner, E. R., Zschocke, J. & Keller, M. A. Phospholipid Acyl Chain Diversity Controls the Tissue-Specific Assembly of Mitochondrial Cardiolipins. Cell Reports 30, 4281-4291.e4 (2020).

Huber, A., Galgóczy, L., Váradi, G., Holzknecht, J., Kakar, A., Malanovic, N., Leber, R., Koch, J., Keller, M. A., Batta, G., Tóth, G. K. & Marx, F. Two small, cysteine-rich and cationic antifungal proteins from Penicillium chrysogenum: A comparative study of PAF and PAFB. Biochimica et Biophysica Acta - Biomembranes 183246 (2020).

Koch, J., Lackner, K., Wohlfarter, Y., Sailer, S., Zschocke, J., Werner, E. R., Watschinger, K. & Keller, M. A. Unequivocal mapping of molecular ether lipid species by LC-MS/MS in plasmalogen-deficient mice. bioRxiv 2020.04.29.066530 (2020).

Oemer, G., Edenhofer, M.-L., Lackner, K., Leman, G., Lindner, H. H., Dubrac, S., Zschocke, J. & Keller, M. A. Fatty Acyl Availability Modulates Cardiolipin Composition and Alters Mitochondrial Function in HeLa Cells. bioRxiv 2020.02.10.937433 (2020).


Huber, A., Oemer, G., Malanovic, N., Lohner, K., Kovács, L., Salvenmoser, W., Zschocke, J., Keller, M. A. & Marx, F. Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of Neurospora crassa. Frontiers in Microbiology 10, 605 (2019).

Keller, M. A., Kampjut, D., Harrison, S. A., Driscoll, P. C. & Ralser, M. Reply to ‘Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor?’ Nature ecology & evolution 3, 139–140 (2019).

Weustenfeld, M., Eidelpes, R., Schmuth, M., Rizzo, W. B., Zschocke, J. & Keller, M. A. Genotype and phenotype variability in Sjögren-Larsson syndrome. Human Mutation 40, 177–186 (2019).

Gnaiger, E., Aasander Frostner, E., Abdul Karim, N., Abumrad, N., Acuna-Castroviejo, D., Adiele, R., Ahn, B., Ali, S., Alton, L., Alves, M., Amati, F., Amoedo, N., Andreadou, I., Arago, M., Aral, C., Arandarcikaite, O., Armand, A., Arnould, T., Avram, V., et al. Mitochondrial respiratory states and rate. (2019).


Zelezniak, A., Vowinckel, J., Capuano, F., Messner, C. B., Demichev, V., Polowsky, N., Mülleder, M., Kamrad, S., Klaus, B.,Keller, M. A. & Ralser, M. Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts. Cell Systems 7, 269-283.e6 (2018).

Keller, M. A., Driscoll, P. C., Messner, C. B. & Ralser, M. 1H-NMR as implemented in several origin of life studies artificially implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed. Wellcome Open Research 2, 52 (2018).

Oemer, G., Lackner, K., Muigg, K., Krumschnabel, G., Watschinger, K., Sailer, S., Lindner, H., Gnaiger, E., Wortmann, S. B., Werner, E. R., Zschocke, J. & Keller, M. A. Molecular structural diversity of mitochondrial cardiolipins. Proceedings of the National Academy of Sciences of the United States of America 115, 4158–4163 (2018).

Werner, E. R., Keller, M. A., Sailer, S., Seppi, D., Golderer, G., Werner-Felmayer, G., Zoeller, R. A. & Watschinger, K. A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. Journal of Lipid Research 59, 901–909 (2018).

Watschinger, K., Keller, M. A., Golderer, G., Coassin, S., Zschocke, J. & Werner, E. R. Biochemical characterization of AGMO variants implicated in relapses in visceral leishmaniasis. Journal of Infectious Diseases 217, 1846–1847 (2018).


Naschberger, A., Orry, A., Lechner, S., Bowler, M. W., Nurizzo, D., Novokmet, M., Keller, M. A., Oemer, G., Seppi, D., Haslbeck, M., Pansi, K., Dieplinger, H. & Rupp, B. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport. Structure 25, 1907-1915.e5 (2017).

Alam, M. T., Olin-Sandoval, V., Stincone, A., Keller, M. A., Zelezniak, A., Luisi, B. F. & Ralser, M. The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization. Nature Communications 8, (2017).

Keller, M. A., Kampjut, D., Harrison, S. A. & Ralser, M. Sulfate radicals enable a non-enzymatic Krebs cycle precursor. Nature Ecology and Evolution 1, 83–83 (2017).


Sheridan, K. J., Lechner, B. E., Keeffe, G. O., Keller, M. A., Werner, E. R., Lindner, H., Jones, G. W., Haas, H. & Doyle, S. Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Scientific Reports 6, 35306 (2016).

Keller, M. A., Zylstra, A., Castro, C., Turchyn, A. V, Griffin, J. L. & Ralser, M. Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway. Science Advances 2 (2016).

Paglia, G., Stocchero, M., Cacciatore, S., Lai, S., Angel, P., Alam, M. T., Keller, M., Ralser, M. & Astarita, G. Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism. Journal of Proteome Research 15, 608–618 (2016).

Campbell, K., Vowinckel, J., Keller, M. A. & Ralser, M. Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway. Antioxidants and Redox Signaling 24, 543–547 (2016).


Campbell, K., Vowinckel, J., Mülleder, M., Malmsheimer, S., Lawrence, N., Calvani, E., Miller-Fleming, L., Alam, M. T., Christen, S., Keller, M. A. & Ralser, M. Self-establishing communities enable cooperative metabolite exchange in a eukaryote. eLife 4, (2015).

Piedrafita, G., Keller, M. A. & Ralser, M. The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (Oxidative) stress conditions. Biomolecules 5, 2101–2122 (2015).

Jack, C. V, Cruz, C., Hull, R. M., Keller, M. A., Ralser, M. & Houseley, J. Regulation of ribosomal DNA amplification by the TOR pathway. Proceedings of the National Academy of Sciences 112, 9674–9679 (2015).

Watschinger, K., Keller, M. A., McNeill, E., Alam, M. T., Lai, S., Sailer, S., Rauch, V., Patel, J., Hermetter, A., Golderer, G., Geley, S., Werner-Felmayer, G., Plumb, R. S., Astarita, G., Ralser, M., Channon, K. M. & Werner, E. R. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proc. Natl. Acad. Sci. U. S. A. 112,2431–2436 (2015).

Michel, S., Keller, M. A., Wamelink, M. M. C. & Ralser, M. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. BMC Genetics 16, (2015).

Keller, M. A., Piedrafita, G. & Ralser, M. The widespread role of non-enzymatic reactions in cellular metabolism. Current Opinion in Biotechnology 34, 153–161 (2015).

Timm, K. N., Hartl, J., Keller, M. A., Hu, D. E., Kettunen, M. I., Rodrigues, T. B., Ralser, M. & Brindle, K. M. Hyperpolarized [U-2H, U-13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells. Magnetic Resonance in Medicine 74, 1543–1547 (2015).

Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin-Sandoval, V., Grüning, N. M., Krüger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D. & Ralser, M. The return of metabolism: Biochemistry and physiology of the pentose phosphate pathway. Biological Reviews 90, 927–963 (2015).


Keller, M. A., Zander, U., Fuchs, J. E., Kreutz, C., Watschinger, K., Mueller, T., Golderer, G., Liedl, K. R., Ralser, M., Kräutler, B., Werner, E. R. & Marquez, J. A. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature communications 5, 4439 (2014).

Keller, M. A., Turchyn, A. V. & Ralser, M. Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean. Mol. Syst. Biol. 10, 725 (2014).

Grüning, N. M., Du, D., Keller, M. A., Luisi, B. F. & Ralser, M. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biology 4, 130232 (2014).


Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R. First insights into structure-function relationships of alkylglycerol monooxygenase. Pteridines 24, 99–103 (2013).

Keller, M. A., Watschinger, K., Golderer, G., Werner-Felmayer, G. & Werner, E. R. Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin- dependent alkylglycerol monooxygenase. Pteridines 24, 105–109 (2013).

Mayer, M., Keller, M. A., Watschinger, K., Werner-Felmayer, G., Werner, E. R. & Golderer, G. Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli. Pteridines 24, 111–115 (2013).


Keller, M. A., Watschinger, K., Lange, K., Golderer, G., Werner-Felmayer, G., Hermetter, A., Wanders, R. J. A. & Werner, E. R. Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds. Journal of Lipid Research 53, 1410–1416 (2012).

Watschinger K., Fuchs J.E., Yarov-Yarovoy V., Keller M.A., Golderer G., Hermetter A., Werner-Felmayer G., Hulo N., Werner E.R. Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol monooxygenase. Biochem J. (2012). 443(1): 279-86.

Watschinger K., Keller M.A., Golderer G., Hermann M., Maglione M., Sarg B., Lindner H., Hermetter A., Werner-Felmayer G., Konrat R., Hulo N., Werner E.R. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proc. Natl. Acad. Sci. USA. (2010) 107 (31): 13672-13677.

Keller M.A., Watschinger K., Golderer G., Maglione M., Sarg B., Lindner H.H., Terrinoni A., Beretta M., Mayer B., Werner-Felmayer G., Werner E.R. Monitoring of Fatty Aldehyde Dehydrogenase by Pyrenedecanal. J. Lipid Res. (2010) 51 (6):1554-9.

Keller M.A., Watschinger K., Golderer G., Maglione M., Werner-Felmayer G., Werner E.R. Role of Fatty Aldehyde Dehydrogenase in Ether Lipid Degradation Pathways. Pteridines (2009) 20(Special issue): 59-63.

Watschinger K., Keller M.A., Golderer G., Hermetter H., Maglione M., Prast H., Werner-Felmayer G., Werner E.R. Alkylglycerol monooxygenase: Properties of an orphan enzyme – an update. Pteridines (2009) 20(Special issue): 55-58.

Werner E.R., Hulo N., Watschinger K., Keller M.A., Golderer G., Werner-Felmayer G. Alkylglycerol monooxygenase candidate genes - is there a common protein motif for tetrahydrobiopterin interaction?. Pteridines (2009) 20(Special issue): 51-54.

Watschinger K., Keller M.A., Hermetter A., Golderer G., Werner-Felmayer G., Werner E.R. Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. Biol Chem. (2009) 390(1):3-10.