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Hubertus Haas Ph.D., Professor

hubertus_haasEMail: hubertus.haas@i-med.ac.at

Phone: +43/(0)512/9003-70205

Fax: +43/(0)512-9003-73100

 

Short curriculum

1983-1988 Studies of Microbiology at the University of Innsbruck/Austria 
1988  Master degree (Mag.rer.nat.), Master thesis: "Establishment of a phleomycin resistance based
transformation system for Penicillium chrysogenum" at the Biochemie GmbH Kundl (Novartis) / Austria
1990  EMBO-Short-Term-Fellowship at the "Max-Planck-Institut für Molekulare Genetik" in Berlin/Germany 
1991  Ph.D. degree (Dr. rer. nat.), Ph.D. thesis: "Characterization of extracellular enzymes and the
encoding genes of Penicillium chrysogenum" at the Department of Microbiology (Med. School)/
University of Innsbruck and at the Biochemie GmbH Kundl(Novartis) / Austria
since 1993 Assistant professor at the Department of Molecular Biology at the University of Innsbruck 
1993-1994 Schrödinger Long-Term-Fellowship at the Department of Biochemistry, Columbus, Ohio/USA 
1999 "Habilitation" (venia docendi) in Microbiology
1999-2019 Associate professor at the Department of Molecular Biology at the University of Innsbruck
since 2019 Professor at the Department of Molecular Biology  at the University of Innsbruck

 

Awards

1996 - Höchst Award

1998 - Brandl Award

 

Research fields

Molecular Microbiology

 

Teaching

From the online catalog of the Innsbruck Medical University (in German): Current lectures

From the online catalog of the University of Innsbruck (in German): Current lectures

 

Publications

  1. Petrik M, Pfister J, Misslinger M, Decristoforo C, Haas H. Siderophore-Based Molecular Imaging of Fungal and Bacterial Infections-Current Status and Future Perspectives. J Fungi (Basel). 2020 May 29;6(2):E73. doi: 10.3390/jof6020073. PMID: 32485852.
  2. Hortschansky P, Misslinger M, Mörl J, Gsaller F, Bromley MJ, Brakhage AA, Groll M, Haas H, Huber EM. Structural basis of HapE<sup>P88L</sup>-linked antifungal triazole resistance in <i>Aspergillus fumigatus</i>. Life Sci Alliance. 2020 May 28;3(7):e202000729. doi: 10.26508/lsa.202000729. PMID: 32467317; PMCID: PMC7266990.
  3. Summer D, Petrik M, Mayr S, Hermann M, Kaeopookum P, Pfister J, Klingler M, Rangger C, Haas H, Decristoforo C. Hybrid Imaging Agents for Pretargeting Applications Based on Fusarinine C-Proof of Concept. Molecules. 2020 May 1;25(9):2123. doi: 10.3390/molecules25092123. PMID: 32370017; PMCID: PMC7249120.
  4. Haselwandter K, Haas H, Häninger G, Winkelmann G. Siderophores in plant root tissue: Tagetes patula nana colonized by the arbuscular mycorrhizal fungus Gigaspora margarita. Biometals. 2020 Jun;33(2-3):137-146. doi: 10.1007/s10534-020-00238-0. Epub 2020 May 3. PMID: 32363469.
  5. Dietl AM, Binder U, Bauer I, Shadkchan Y, Osherov N, Haas H. Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of <i>Aspergillus fumigatus</i>. Genes (Basel). 2020 Apr 15;11(4):423. doi: 10.3390/genes11040423. PMID: 32326414; PMCID: PMC7231135.
  6. Birštonas L, Dallemulle A, López-Berges MS, Jacobsen ID, Offterdinger M, Abt B, Straßburger M, Bauer I, Schmidt O, Sarg B, Lindner H, Haas H, Gsaller F. Multiplex Genetic Engineering Exploiting Pyrimidine Salvage Pathway-Based Endogenous Counterselectable Markers. mBio. 2020 Apr 7;11(2):e00230-20. doi: 10.1128/mBio.00230-20. PMID: 32265325; PMCID: PMC7157766.
  7. Pahlow S, Orasch T, Žukovskaja O, Bocklitz T, Haas H, Weber K. Rapid detection of the aspergillosis biomarker triacetylfusarinine C using interference-enhanced Raman spectroscopy. Anal Bioanal Chem. 2020 Mar 14. doi: 10.1007/s00216-020-02571-2. Epub ahead of print. PMID: 32170382.
  8. Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P. The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res. 2020 Feb 22. pii: gkaa109. doi: 10.1093/nar/gkaa109. [Epub ahead of print] PubMed PMID: 32086516.
  9. Pfister J, Summer D, Petrik M, Khoylou M, Lichius A, Kaeopookum P, Kochinke L, Orasch T, Haas H, Decristoforo C. Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, (68)Ga-Labelled Siderophores. Biomolecules. 2020 Jan 22;10(2). pii: E168. doi: 10.3390/biom10020168. PubMed PMID: 31979017.
  10. Bauer I, Misslinger M, Shadkchan Y, Dietl AM, Petzer V, Orasch T, Abt B, Graessle S, Osherov N, Haas H. The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus. Front Microbiol. 2019 Dec 4;10:2773. doi: 10.3389/fmicb.2019.02773. eCollection 2019. PubMed PMID: 31866965; PubMed Central PMCID: PMC6905131.
  11. Nazik H, Sass G, Ansari SR, Ertekin R, Haas H, Déziel E, Stevens DA. Novel intermicrobial molecular interaction: Pseudomonas aeruginosa Quinolone Signal (PQS) modulates Aspergillus fumigatus response to iron. Microbiology. 2020 Jan;166(1):44-55. doi: 10.1099/mic.0.000858. Epub 2019 Nov 15. PubMed PMID: 31778108.
  12. Orasch T, Dietl AM, Shadkchan Y, Binder U, Bauer I, Lass-Flörl C, Osherov N, Haas H. The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus. Virulence. 2019 Dec;10(1):925-934. doi: 10.1080/21505594.2019.1682760. PubMed PMID: 31694453; PubMed Central PMCID: PMC6844326.
  13. Kaeopookum P, Petrik M, Summer D, Klinger M, Zhai C, Rangger C, Haubner R, Haas H, Hajduch M, Decristoforo C. Comparison of (68)Ga-labeled RGD mono- and multimers based on a clickable siderophore-based scaffold. Nucl Med Biol. 2019 Nov - Dec;78-79:1-10. doi: 10.1016/j.nucmedbio.2019.09.002. Epub 2019 Oct 25. PubMed PMID: 31678781.
  14. Misslinger M, Scheven MT, Hortschansky P, López-Berges MS, Heiss K, Beckmann N, Heigl T, Hermann M, Krüger T, Kniemeyer O, Brakhage AA, Haas H. The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. PLoS Genet. 2019 Sep 16;15(9):e1008379. doi: 10.1371/journal.pgen.1008379. eCollection 2019 Sep. PubMed PMID: 31525190; PubMed Central PMCID: PMC6762210.
  15. Dietl AM, Misslinger M, Aguiar MM, Ivashov V, Teis D, Pfister J, Decristoforo C, Hermann M, Sullivan SM, Smith LR, Haas H. The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397. Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00807-19. doi: 10.1128/AAC.00807-19. Print 2019 Oct. PubMed PMID: 31405865; PubMed Central PMCID: PMC6761561.
  16. Petzer V, Wermke M, Tymoszuk P, Wolf D, Seifert M, Ovaçin R, Berger S, Orth-Höller D, Loacker L, Weiss G, Haas H, Platzbecker U, Theurl I. Enhanced labile plasma iron in hematopoietic stem cell transplanted patients promotes Aspergillus outgrowth. Blood Adv. 2019 Jun 11;3(11):1695-1700. doi: 10.1182/bloodadvances.2019000043. PubMed PMID: 31167821; PubMed Central PMCID: PMC6560355.
  17. Sass G, Ansari SR, Dietl AM, Déziel E, Haas H, Stevens DA. Intermicrobial interaction: Aspergillus fumigatus siderophores protect against competition by Pseudomonas aeruginosa. PLoS One. 2019 May 8;14(5):e0216085. doi: 10.1371/journal.pone.0216085. eCollection 2019. PubMed PMID: 31067259; PubMed Central PMCID: PMC6505954.
  18. Zhai C, He S, Ye Y, Rangger C, Kaeopookum P, Summer D, Haas H, Kremser L, Lindner H, Foster J, Sosabowski J, Decristoforo C. Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89. Biomolecules. 2019 Mar 6;9(3). pii: E91. doi: 10.3390/biom9030091. PubMed PMID: 30845658; PubMed Central PMCID: PMC6468543.
  19. Kaeopookum P, Summer D, Pfister J, Orasch T, Lechner BE, Petrik M, Novy Z, Matuszczak B, Rangger C, Haas H, Decristoforo C. Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection. Mol Imaging Biol. 2019 Dec;21(6):1097-1106. doi: 10.1007/s11307-019-01325-6. PubMed PMID: 30838551; PubMed Central PMCID: PMC6877352.
  20. Sass G, Nazik H, Penner J, Shah H, Ansari SR, Clemons KV, Groleau MC, Dietl AM, Visca P, Haas H, Déziel E, Stevens DA. Aspergillus-Pseudomonas interaction, relevant to competition in airways. Med Mycol. 2019 Apr 1;57(Supplement_2):S228-S232. doi: 10.1093/mmy/myy087. Review. PubMed PMID: 30816973.
  21. Kenno S, Speth C, Rambach G, Binder U, Chatterjee S, Caramalho R, Haas H, Lass-Flörl C, Shaughnessy J, Ram S, Gow NAR, Orth-Höller D, Würzner R. Candida albicans Factor H Binding Molecule Hgt1p - A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils. Front Microbiol. 2019 Jan 15;9:3319. Doi 10.3389/fmicb.2018.03319. eCollection 2018. PubMed PMID: 30697200; PubMed Central PMCID: PMC6340940.
  22. Dietl AM, Binder U, Shadkchan Y, Osherov N, Haas H. Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus. Front Microbiol. 2018 Nov 12;9:2615. doi: 10.3389/fmicb.2018.02615. eCollection 2018. PubMed PMID: 30483221; PubMed Central PMCID: PMC6240589.
  23. Misslinger M, Lechner BE, Bacher K, Haas H. Iron-sensing is governed by mitochondrial, not by cytosolic iron-sulfur cluster biogenesis in Aspergillus fumigatus. Metallomics. 2018 Nov 14;10(11):1687-1700. doi: 10.1039/c8mt00263k. PubMed PMID: 30395137; PubMed Central PMCID: PMC6250123.
  24. Steger M, Bermejo-Jambrina M, Yordanov T, Wagener J, Brakhage AA, Pittl V, Huber LA, Haas H, Lass-Flörl C, Posch W, Wilflingseder D. β-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells. Virulence. 2019 Dec;10(1):957-969. doi: 10.1080/21505594.2018.1528843. Epub 2018 Oct 29. PubMed PMID: 30372658.
  25. Long N, Orasch T, Zhang S, Gao L, Xu X, Hortschansky P, Ye J, Zhang F, Xu K, Gsaller F, Straßburger M, Binder U, Heinekamp T, Brakhage AA, Haas H, Lu L. The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. PLoS Genet. 2018 Oct 26;14(10):e1007762. doi: 10.1371/journal.pgen.1007762. eCollection 2018 Oct PubMed PMID: 30365497; PubMed Central PMCID: PMC6221358.
  26. Petrik M, Umlaufova E, Raclavsky V, Palyzova A, Havlicek V, Haas H, Novy Z, Dolezal D, Hajduch M, Decristoforo C. Imaging of Pseudomonas aeruginosa infection with Ga-68 labelled pyoverdine for positron emission tomography. Sci Rep. 2018 Oct 24;8(1):15698. doi: 10.1038/s41598-018-33895-w. PubMed PMID: 30356077; PubMed Central PMCID: PMC6200719.
  27. Hoenigl M, Orasch T, Faserl K, Prattes J, Loeffler J, Springer J, Gsaller F, Reischies F, Duettmann W, Raggam RB, Lindner H, Haas H. Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis. J Infect. 2019 Feb;78(2):150-157. doi: 10.1016/j.jinf.2018.09.006. Epub 2018 Sep 26. PubMed PMID: 30267801; PubMed Central PMCID: PMC6361682.
  28. Ecker F, Haas H, Groll M, Huber EM. Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases. Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14624-14629. doi: 10.1002/anie.201807093. Epub 2018 Aug 27. PubMed PMID: 30070018. Summer D, Kroess A, Woerndle R, Rangger C, Klingler M, Haas H, Kremser L, Lindner HH, von Guggenberg E, Decristoforo C. Multimerization results information of re-bindable metabolites: A proof of concept study with FSC-based minigastrin imaging probes targeting CCK2R expression. PLoS One. 2018 Jul 30;13(7):e0201224. doi: 10.1371/journal.pone.0201224. eCollection 2018. PubMed PMID: 30059514; PubMed Central PMCID: PMC6066219.
  29. Jahreis S, Böttcher S, Hartung S, Rachow T, Rummler S, Dietl AM, Haas H, Walther G, Hochhaus A, von Lilienfeld-Toal M. Human MAIT cells are rapidly activated by Aspergillus spp. in an APC-dependent manner. Eur J Immunol. 2018 Oct;48(10):1698-1706. doi: 10.1002/eji.201747312. Epub 2018 Aug 13. PubMed PMID: 30059139.
  30. Dietl AM, Meir Z, Shadkchan Y, Osherov N, Haas H. Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus. Virulence. 2018;9(1):1036-1049. doi: 10.1080/21505594.2018.1482181. PubMed PMID: 30052132; PubMed Central PMCID: PMC6068542.
  31. Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K. Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell. 2018 Jun 14;5(7):300-326. doi: 10.15698/mic2018.07.638. Review. PubMed PMID: 29992128; PubMed Central PMCID: PMC6035839.
  32. Summer D, Rangger C, Klingler M, Laverman P, Franssen GM, Lechner BE, Orasch T, Haas H, von Guggenberg E, Decristoforo C. Exploiting the Concept of Multivalency with (68)Ga- and (89)Zr-Labelled Fusarinine C-Minigastrin Bioconjugates for Targeting CCK2R Expression. Contrast Media Mol Imaging. 2018 Apr 10;2018:3171794. doi: 10.1155/2018/3171794. eCollection 2018. PubMed PMID: 29849512; PubMed Central PMCID: PMC5914118.
  33. Kurucz V, Krüger T, Antal K, Dietl AM, Haas H, Pócsi I, Kniemeyer O, Emri T. Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion. BMC Genomics. 2018 May 10;19(1):357. doi: 10.1186/s12864-018-4730-x. PubMed PMID: 29747589; PubMed Central PMCID: PMC5946477.
  34. Hsu JL, Manouvakhova OV, Clemons KV, Inayathullah M, Tu AB, Sobel RA, Tian A, Nazik H, Pothineni VR, Pasupneti S, Jiang X, Dhillon GS, Bedi H, Rajadas J, Haas H, Aurelian L, Stevens DA, Nicolls MR. Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation. Sci Transl Med. 2018 Feb 21;10(429). pii: eaag2616. doi:10.1126/scitranslmed.aag2616. PubMed PMID: 29467298; PubMed Central PMCID: PMC5841257.
  35. Misslinger M, Gsaller F, Hortschansky P, Müller C, Bracher F, Bromley MJ, Haas H. The cytochrome b(5) CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus. Metallomics. 2017 Nov 15;9(11):1655-1665.doi: 10.1039/c7mt00110j. PubMed PMID: 29072765.
  36. Sass G, Nazik H, Penner J, Shah H, Ansari SR, Clemons KV, Groleau MC, Dietl AM, Visca P, Haas H, Déziel E, Stevens DA. Studies of Pseudomonas aeruginosa Mutants Indicate Pyoverdine as the Central Factor in Inhibition of Aspergillus fumigatus Biofilm. J Bacteriol. 2017 Dec 5;200(1). pii: e00345-17. doi: 10.1128/JB.00345-17. Print 2018 Jan 1. PubMed PMID: 29038255; PubMed Central PMCID: PMC5717155.
  37. Orasch T, Prattes J, Faserl K, Eigl S, Düttmann W, Lindner H, Haas H, Hoenigl M. Bronchoalveolar lavage triacetylfusarinine C (TAFC) determination for diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies. J Infect. 2017 Oct;75(4):370-373. doi: 10.1016/j.jinf.2017.05.014. Epub 2017 May 31. PubMed PMID: 28576596; PubMed Central PMCID: PMC5757784.
  38. Summer D, Grossrubatscher L, Petrik M, Michalcikova T, Novy Z, Rangger C, Klingler M, Haas H, Kaeopookum P, von Guggenberg E, Haubner R, Decristoforo C. Developing Targeted Hybrid Imaging Probes by Chelator Scaffolding. Bioconjug Chem. 2017 Jun 21;28(6):1722-1733. doi: 10.1021/acs.bioconjchem.7b00182. Epub 2017 May 10. PubMed PMID: 28462989; PubMed Central PMCID: PMC5481817.
  39. Nairz M, Schroll A, Haschka D, Dichtl S, Tymoszuk P, Demetz E, Moser P, Haas H, Fang FC, Theurl I, Weiss G. Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection. Front Cell Infect Microbiol. 2017 Apr 11;7:110. doi: 10.3389/fcimb.2017.00110. eCollection 2017 PubMed PMID: 28443246; PubMed Central PMCID: PMC5387078.
  40. Petrik M, Zhai C, Haas H, Decristoforo C. Siderophores for molecular imaging applications. Clin Transl Imaging. 2017;5(1):15-27. doi: 10.1007/s40336-016-0211-x. Epub 2016 Oct 11. Review. PubMed PMID: 28138436; PubMed Central PMCID: PMC5269471.
  41. Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ. Correction: Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog. 2016 Dec 14;12(12):e1006106. doi: 10.1371/journal.ppat.1006106. eCollection 2016 Dec. PubMed PMID: 27973537; PubMed Central PMCID: PMC5156360.
  42. Hortschansky P, Haas H, Huber EM, Groll M, Brakhage AA. The CCAAT-binding complex (CBC) in Aspergillus species. Biochim Biophys Acta Gene Regul Mech. 2017 May;1860(5):560-570. doi: 10.1016/j.bbagrm.2016.11.008. Epub 2016 Dec 8. Review. PubMed PMID: 27939757.
  43. Sheridan KJ, Lechner BE, Keeffe GO, Keller MA, Werner ER, Lindner H, Jones GW, Haas H, Doyle S. Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Sci Rep. 2016 Oct 17;6:35306. doi: 10.1038/srep35306. PubMed PMID: 27748436; PubMed Central PMCID: PMC5066259.
  44. Pasricha S, Schafferer L, Lindner H, Joanne Boyce K, Haas H, Andrianopoulos A. Differentially regulated high-affinity iron assimilation systems support growth of the various cell types in the dimorphic pathogen Talaromyces marneffei. Mol Microbiol. 2016 Nov;102(4):715-737. doi: 10.1111/mmi.13489. Epub 2016 Sep 23. PubMed PMID: 27558514.
  45. Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ. Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog. 2016 Jul 20;12(7):e1005775. doi: 10.1371/journal.ppat.1005775. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2016 Dec 14;12 (12 ):e1006106. PubMed PMID: 27438727; PubMed Central PMCID: PMC4954732.
  46. Kaltdorf M, Srivastava M, Gupta SK, Liang C, Binder J, Dietl AM, Meir Z, Haas H, Osherov N, Krappmann S, Dandekar T. Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach. Front Mol Biosci. 2016 Jun 17;3:22. doi: 10.3389/fmolb.2016.00022. eCollection 2016. PubMed PMID: 27379244; PubMed Central PMCID: PMC4911368.
  47. Zhai C, Franssen GM, Petrik M, Laverman P, Summer D, Rangger C, Haubner R, Haas H, Decristoforo C. Comparison of Ga-68-Labeled Fusarinine C-Based Multivalent RGD Conjugates and [(68)Ga]NODAGA-RGD-In Vivo Imaging Studies in Human Xenograft Tumors. Mol Imaging Biol. 2016 Oct;18(5):758-67. doi: 10.1007/s11307-016-0931-3. PubMed PMID: 26905697; PubMed Central PMCID: PMC5010584.
  48. Dietl AM, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H. Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence. 2016 May 18;7(4):465-76. doi: 10.1080/21505594.2016.1146848. Epub 2016 Feb 6. PubMed PMID: 26854126; PubMed Central PMCID: PMC4871644.
  49. Ben Yaakov D, Rivkin A, Mircus G, Albert N, Dietl AM, Kovalerchick D, Carmeli S, Haas H, Kontoyiannis DP, Osherov N. Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis. J Antimicrob Chemother. 2016 Apr;71(4):946-52. doi: 10.1093/jac/dkv446. Epub 2016 Jan 7. PubMed PMID: 26747101; PubMed Central PMCID: PMC5757792.
  50. Petrik M, Zhai C, Novy Z, Urbanek L, Haas H, Decristoforo C. In Vitro and In Vivo Comparison of Selected Ga-68 and Zr-89 Labelled Siderophores. Mol Imaging Biol. 2016 Jun;18(3):344 52. doi: 10.1007/s11307-015-0897-6. PubMed PMID: 26424719; PubMed Central PMCID: PMC4870302.
  51. Haas H. How to trigger a fungal weapon. Elife. 2015 Sep 1;4. doi: 10.7554/eLife.10504. PubMed PMID: 26327696; PubMed Central PMCID: PMC4555636.
  52. Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM. Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi: 10.1371/journal.ppat.1004943. eCollection 2015 Jun. PubMed PMID: 26086393; PubMed Central PMCID: PMC4472839.
  53. Zhai C, Summer D, Rangger C, Franssen GM, Laverman P, Haas H, Petrik M, Haubner R, Decristoforo C. Novel Bifunctional Cyclic Chelator for (89)Zr Labeling-Radiolabeling and Targeting Properties of RGD Conjugates. Mol Pharm. 2015 Jun 1;12(6):2142-50. doi: 10.1021/acs.molpharmaceut.5b00128. Epub 2015 May 19. PubMed PMID: 25941834; PubMed Central PMCID: PMC4453016.
  54. Schafferer L, Beckmann N, Binder U, Brosch G, Haas H. AmcA-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis. Front Microbiol. 2015 Apr 7;6:252. doi: 10.3389/fmicb.2015.00252. eCollection 2015. PubMed PMID: 25904899; PubMed Central PMCID: PMC4387927.
  55. Zhai C, Summer D, Rangger C, Haas H, Haubner R, Decristoforo C. Fusarinine C, a novel siderophore-based bifunctional chelator for radiolabeling with Gallium-68. J Labelled Comp Radiopharm. 2015 May 15;58(5):209-14. doi: 10.1002/jlcr.3286. Epub 2015 Apr 15. PubMed PMID: 25874571; PubMed Central PMCID: PMC4682187.
  56. Baldin C, Valiante V, Krüger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA. Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics. 2015 Jul;15(13):2230-43. doi: 10.1002/pmic.201400584. Epub 2015 May 26. PubMed PMID: 25728394.
  57. Briard B, Bomme P, Lechner BE, Mislin GL, Lair V, Prévost MC, Latgé JP, Haas H, Beauvais A. Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines. Sci Rep. 2015 Feb 10;5:8220. doi: 10.1038/srep08220. PubMed PMID: 25665925; PubMed Central PMCID: PMC5389140.
  58. Haas H, Petrik M, Decristoforo C. An iron-mimicking, Trojan horse-entering fungi--has the time come for molecular imaging of fungal infections? PLoS Pathog. 2015 Jan 29;11(1):e1004568. doi: 10.1371/journal.ppat.1004568. eCollection 2015 Jan. PubMed PMID: 25634225; PubMed Central PMCID: PMC4310729.
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  65. Silva-Bailão MG, Bailão EF, Lechner BE, Gauthier GM, Lindner H, Bailão AM Haas H, de Almeida Soares CM. Hydroxamate production as a high affinity iron acquisition mechanism in Paracoccidioides spp. PLoS One. 2014 Aug 26;9(8):e105805. doi: 10.1371/journal.pone.0105805. eCollection 2014. PubMed PMID: 25157575; PubMed Central PMCID: PMC4144954.
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  70. Vergeiner S, Schafferer L, Haas H, Müller T. Improved MALDI-TOF microbial mass spectrometry imaging by application of a dispersed solid matrix. J Am Soc Mass Spectrom. 2014 Aug;25(8):1498-501. doi: 10.1007/s13361-014-0923-y. Epub 2014 Jun 4. PubMed PMID: 24894842.
  71. Albarouki E, Schafferer L, Ye F, von Wirén N, Haas H, Deising HB. Biotrophy-specific downregulation of siderophore biosynthesis in Colletotrichum graminicola is required for modulation of immune responses of maize. Mol Microbiol. 2014 Apr;92(2):338-55. doi: 10.1111/mmi.12561. Epub 2014 Mar 17. PubMed PMID: 24674132; PubMed Central PMCID: PMC4235341.
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  76. Amich J, Schafferer L, Haas H, Krappmann S. Regulation of Sulphur assimilation is essential for virulence and affects iron homeostasis of the human-pathogenic mould Aspergillus fumigatus. PLoS Pathog. 2013;9(8):e1003573. doi: 10.1371/journal.ppat.1003573. Epub 2013 Aug 29. PubMed PMID: 24009505; PubMed Central PMCID: PMC3757043.
  77. Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D. Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol. 2013 Nov;79(21):6670-6. doi: 10.1128/AEM.02642-13. Epub 2013 Aug 23. PubMed PMID: 23974138; PubMed Central PMCID: PMC3811484.
  78. Leal SM Jr, Roy S, Vareechon C, Carrion Sd, Clark H, Lopez-Berges MS, Di Pietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E. Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog. 2013;9(7):e1003436. doi: 10.1371/journal.ppat.1003436. Epub 2013 Jul 11. Erratum in: PLoS Pathog. 2013 Jul;9(7). doi:10.1371/annotation/4f388450-90fe-4c65-9b9b-71a2b7935ac0. diPietro, Antonio [corrected to Di Pietro, Antonio]. PubMed PMID: 23853581; PubMed Central PMCID: PMC3708856.
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  80. Petrik M, Haas H, Laverman P, Schrettl M, Franssen GM, Blatzer M, Decristoforo C. 68Ga-triacetylfusarinine C and 68Ga-ferrioxamine E for
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  96. Hegedus N, Leiter E, Kovács B, Tomori V, Kwon NJ, Emri T, Marx F, Batta G, Csernoch L, Haas H, Yu JH, Pócsi I. The small molecular mass antifungal protein of Penicillium chrysogenum--a mechanism of action oriented review. J Basic Microbiol. 2011 Dec;51(6):561-71. doi: 10.1002/jobm.201100041. Epub 2011 Jul 21. Review. PubMed PMID: 21780144.
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  106. Thön M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA. The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res. 2010 Mar;38(4):1098-113. doi: 10.1093/nar/gkp1091. Epub 2009 Dec 3. PubMed PMID: 19965775; PubMed Central PMCID: PMC2831313.
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  117. Blum G, Perkhofer S, Haas H, Schrettl M, Würzner R, Dierich MP, Lass-Flör C. Potential basis for amphotericin B resistance in Aspergillus terreus. Antimicrob Agents Chemother. 2008 Apr;52(4):1553-5. doi: 10.1128/AAC.01280-07. Epub 2008 Feb 11. PubMed PMID: 18268082; PubMed Central PMCID: PMC2292529.
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  121. Oide S, Moeder W, Krasnoff S, Gibson D, Haas H, Yoshioka K, Turgeon BG. NPS6, encoding a nonribosomal peptide synthetase involved in siderophore-mediated iron metabolism, is a conserved virulence determinant of plant pathogenic ascomycetes. Plant Cell. 2006 Oct;18(10):2836-53. Epub 2006 Oct 20. PubMed PMID: 17056706; PubMed Central PMCID: PMC1626607.
  122. Eisendle M, Schrettl M, Kragl C, Müller D, Illmer P, Haas H. The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell. 2006 Oct;5(10):1596-603. PubMed PMID: 17030991; PubMed Central PMCID: PMC1595343.
  123. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, García JL, García MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jiménez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latgé JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Peñalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Córdoba S, Rodríguez-Peña JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sánchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 2005 Dec 22;438(7071):1151-6. Erratum in: Nature. 2006 Jan 26;439(7075):502. Lafton, Anne [corrected to Lafon, Anne]. PubMed PMID: 16372009.
  124. Tribus M, Galehr J, Trojer P, Brosch G, Loidl P, Marx F, Haas H, Graessle S. HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress. Eukaryot Cell. 2005 Oct;4(10):1736-45. PubMed PMID: 16215180; PubMed Central PMCID: PMC1265891.
  125. Schrettl M, Winkelmann G, Haas H. Ferrichrome in Schizosaccharomyces pombe--an iron transport and iron storage compound. Biometals. 2004 Dec;17(6):647-54. PubMed PMID: 15689108.
  126. Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN Jr, Haynes K, Haas H. Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med. 2004 Nov 1;200(9):1213-9. Epub 2004 Oct 25. PubMed PMID: 15504822; PubMed Central PMCID: PMC2211866.
  127. Fluckinger M, Haas H, Merschak P, Glasgow BJ, Redl B. Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores. Antimicrob  Agents Chemother. 2004 Sep;48(9):3367-72. PubMed PMID: 15328098; PubMed Central PMCID: PMC514737.
  128. Eisendle M, Oberegger H, Buttinger R, Illmer P, Haas H. Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans. Eukaryot Cell. 2004 Apr;3(2):561-3. PubMed PMID: 15075286; PubMed Central PMCID: PMC387658.
  129. Leiter, E., Marx, F., Pusztahelyi, T., Haas, H. and Pocsi, I. (2004) Penicillium chrysogenum glucose oxidase - a study on its antifungal effects. J. Appl. Microbiol. 97: 1201-1209. 
  130. Oberparleiter C, Kaiserer L, Haas H, Ladurner P, Andratsch M, Marx F. Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli. Antimicrob Agents Chemother. 2003 Nov;47(11):3598-601. PubMed PMID: 14576124; PubMed Central PMCID: PMC253792.
  131. Haas H (2003). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl. Microbiol. Biot. 62: 316-30. 
  132. Oberegger H, Eisendle M, Schrettl M, Graessle S, Haas H. 4'-phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans. Curr Genet. 2003 Dec;44(4):211-5. Epub 2003 Sep 24. PubMed PMID: 14508603.
  133. Trojer P, Brandtner EM, Brosch G, Loidl P, Galehr J, Linzmaier R, Haas H, Mair K, Tribus M, Graessle S. Histone deacetylases in fungi: novel members, new facts. Nucleic Acids Res. 2003 Jul 15;31(14):3971-81. PubMed PMID: 12853613; PubMed Central PMCID: PMC167634.
  134. Eisendle M, Oberegger H, Zadra I, Haas H. The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol. 2003 Jul;49(2):359-75. PubMed PMID: 12828635.
  135. Greene AV, Keller N, Haas H, Bell-Pedersen D. A circadian oscillator in Aspergillus spp. regulates daily development and gene expression. Eukaryot Cell. 2003 Apr;2(2):231-7. PubMed PMID: 12684372; PubMed Central PMCID: PMC154850.
  136. Haas H, Schoeser M, Lesuisse E, Ernst JF, Parson W, Abt B, Winkelmann G, Oberegger H. Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C. Biochem J. 2003 Apr 15;371(Pt 2):505-13. PubMed PMID: 12487628; PubMed Central PMCID: PMC1223275.
  137. Oberegger H, Schoeser M, Zadra I, Schrettl M, Parson W, Haas H. Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus Nidulans. Appl Environ Microbiol. 2002 Nov;68(11):5769-72. PubMed PMID: 12406779; PubMed Central PMCID: PMC129941.
  138. Oberegger H, Zadra I, Schoeser M, Abt B, Parson W & Haas H (2002). Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization. Bioch. Soc. Trans. 30(4):781-783  
  139. Oberegger H, Schoeser M, Zadra I, Abt B & Haas H (2001). SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans. Mol. Microbiol. 41(5): 1077-1089.  
  140. Conlon H, Zadra I, Haas H, Arst HN, Jones MG & Caddick MX (2001). The Aspergillus nidulans GATA transcription factor gene areBencodes at least three proteins and features three classes of mutation. Mol. Microbiol. 40(2): 361-375.  
  141. Dangl M, Brosch G, Haas H, Loidl P & Lusser A (2001). Comparative analysis of HD2 type histone deacetylases in higher plants. Planta 213, 280-285.  
  142. Oberegger H, Zadra I, Schoeser M & Haas H (2000). Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus. FEBS letters, 485:113-116.  
  143. Zadra I, Abt B, Parson W & Haas H (2000). AxylP promoter-based expression system and its use for antisense downregulation of the Penicillium chrysogenum nitrogen regulator NRE. Appl. Environ. Microbiol. 66:4810-4816.  
  144. Feng B, Haas H & Marzluf GA (2000). ASD4, a new GATA factor of Neurospora crassa, displays sequence-specific DNA binding and functions in ascus and ascospore development. Biochemistry 39:11065-73.  
  145. Graessle S, Dangl M, Haas H, Mair K, Trojer P, Brandtner E, Walton JD, Loidl P & Brosch G. (2000). Characterization of two putative histone deacylase genes from Aspergillus nidulans. Biochim. Biophys. Acta 1492:120-6.  
  146. Lusser A, Eberharter A, Loidl A, Goralik-Schramel M, Haas H & Loidl P (1999). Analysis of the histone acetyltransferasae B complex of maize embryos. Nucl. Acids Res. 27:4427-35.  
  147. Haas H (1999). GATA- factors and nitrogen metabolism in filamentous fungi. Amino Acids 17:98. Abstract.  
  148. Haas H, Zadra I, Stöffler G & Angermayr K (1999). The Aspergillus nidulans GATA-factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J. Biol. Chem. 274:4613-4619.  
  149. Angermayr K, Parson W, Stöffler G & Haas H (1999). Expression of atrC - encoding a novel member of the ATP-binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. Biochim. Biophys. Acta 1453:304-310.  
  150. Dangl M, Lusser A, Brosch G, Loidl A, Haas H & Loidl P (1998). Second family of histone deacetylases. Science 280:1167a (www.sciencemag.org). Technical comment.  
  151. Zhou L, Haas H & Marzluf GA (1998). Isolation and characterization of a new gene, sre, which encodes a GATA-type regulatory protein that controls iron transport in Neurospora crassa. Mol. Gen. Genet. 259:532-540.  
  152. Haas H, Angermayr K, Zadra I, & Stöffler G (1997). Overexpression of nreB, a new GATA factor-encoding gene of Penicillium chrysogenum, leads to repression of the nitrate assimilatory gene cluster. J. Biol. Chem. 272:22576-22582.  
  153. Lusser A, Brosch G, Loidl A, Haas H & Loidl P (1997). Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein. Science 277:88-91.  
  154. Lusser A, Brosch G, Loidl A, Haas H & Loidl P (1997). A Novel Type of Histonedeacetylases: Molecular Cloning and Sequencing of HD2 of Z. mays. 17th International Congress of Biochemistry and Molecular Biology, FASEB Journal 11(9). Abstract.  
  155. Graessle S, Haas H, Friedlin E, Kürnsteiner H, Stöffler G & Redl B (1997). Regulated system for heterologous gene expression in Penicllium chrysogenum. Appl. Env. Microbiol. 63:753-756.  
  156. Haas H, Angermayr K & Stöffler G (1997). Molecular analysis of a Penicillium chrysogenum GATA factor encoding gene (sreP) exhibiting significant homology to the Ustilago maydis urbs1 gene. Gene 184:33-37.  
  157. Haas H, Zadra I & Graessle S (1996). Partial sequence of the actin encoding gene (actA) of Penicillium chrysogenum. GenBank accession number U61733.  
  158. Haas H, Marx F, Graessle S & Stöffler G (1996). Sequence analysis and expression of the Penicillium chrysogenum nitrate reductase encoding gene (niaD). Biochim. Biophys. Acta 1309:81-84.  
  159. Marx F, Haas H, Reindl M, Stöffler G, Lottspeich F & Redl B (1995). Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity. Gene 167:167-171.  
  160. Marx F, Haas H, Hofer S, Stöffler G & Redl B (1995). Sequence and structure of Penicillium chrysogenum phoG, homologous to an acid phosphatase encoding gene of Aspergillus nidulansGene 160:137-138.  
  161. Haas H & Marzluf GA (1995). NRE, the major nitrogen regulatory protein of Penicillium chrysogenum, binds specifically in the intergenic promoter regions of nitrate assimilation and penicillin biosynthetic gene clusters. Curr. Genet. 28:177-183.  
  162. Haas H, Bauer B, Redl B, Stöffler G & Marzluf GA (1995). Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenumCurr. Genet. 27:150-158.  
  163. Haas H, Friedlin E, Stöffler G & Redl B (1993). Cloning and structural organization of a xylanase-encoding gene from Penicillium chrysogenumGene 126:237-242.  
  164. Haas H, Redl B, Herfurth E & Stöffler G (1992). Purification, characterization and partial amino acid sequences of a xylanase produced by Penicillium chrysogenum. Biochim. Biophys. Acta 1117:279-286.  
  165. Haas H, Redl B, Friedlin E & Stöffler G (1992). Isolation and molecular analysis of the Penicillium chrysogenum phoA gene encoding a secreted phosphate-repressible acid phosphatase. Gene 113:129-133.  
  166. Haas H, Redl B, Leitner E & Stöffler G (1991). Penicillium chrysogenum extracellular acid phosphatase: purification and biochemical characterization. Biochim. Biophys. Acta 1074:392-397. 

Institut für Molekularbiologie