Sektion für Molekularbiologie

Fabio Gsaller PhD.

fabio_gsaller

EMail: fabio.gsaller@i-med.ac.at

Phone: +43/(0)512/9003-70224

Fax: +43/(0)512-9003-73100

 

 

 

 

 

 

 

 

 

 

 

 

 

Short curriculum

2004-2008 Bachelor studies of Biology at the Leopold-Franzens-University Innsbruck
2008

Practical training at Dr. Norbert Polacek’s Lab, Division of Genomics and 
RNomics, Medical University of Innsbruck

2008-2010

Master Studies at the Leopold-Franzens-University Innsbruck. 
Thesis: ‘The role of HapX as transcriptional regulator in iron homeostasis of Aspergillus spp.

2010-2013

PhD Studies at the Medical University of Innsbruck. 
Thesis: ‘Iron Metabolism in Acremonium chrysogenum and Aspergillus spp.

2013-2015

PostDoctoral Scientist on the EU FP7 project NOFUN at the Manchester 
Fungal Infection Group, University of Manchester (UK)

2015-2017

Erwin-Schrödinger Fellow at the Manchester Fungal Infection Group, 
University of Manchester (UK)

2017-2018

Erwin-Schrödinger Fellow at the Molecular Biology Division, Medical University of Innsbruck
Project: Genetic Pursuit of Antifungal Drug Mechanisms of Action

current role(s)

Principal Investigator at the Molecular Biology Division, Medical University of Innsbruck

Honorary Senior Research Fellow, University of Manchester

 

Awards

2013 - Award of Excellence (Austrian Federal Ministry of Science, Research and Economy)

2014 - Erwin-Schrödinger PostDoctoral Fellowship (Austrian Science Fund FWF & the European Union)

2015 - Medical Research Grant (The Dowager Countess Eleanor Peel Trust &
           The Fungal Infection Trust), UK

2016 - FEBS Short-Term Fellowship (Federation of European Biochemical Societies)

2017 - Young Scientist Development Award for Clinical Mycology (German-speaking mycological society)

2018 - FWF Stand-Alone Project (Austrian Science Fund FWF)

2018 - Swarovski Forschungsförderung (D. Swarovski & Co.)

2018 - Publication Award (German-speaking mycological society)

 

Research fields

Antifungal Research

 

Publications

  1. Hoenigl M, Orasch T, Faserl K, Prattes J, Loeffler J, Springer J, Gsaller F, Reischies F, Duettmann W, Raggam RB, Lindner H, Haas H. 2018. Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis. J Infect doi:10.1016/j.jinf.2018.09.006.

  2. Long N, Orasch T, Zhang S, Gao L, Xu X, Hortschansky P, Ye J, Zhang F, Xu K, Gsaller F, Strassburger M, Binder U, Heinekamp T, Brakhage AA, Haas H, Lu L. 2018. The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. PLoS Genet 14:e1007762.

  3. Gsaller F, Furukawa T, Carr PD, Rash B, Jochl C, Bertuzzi M, Bignell EM, Bromley MJ. 2018. Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus. Antimicrob Agents Chemother 62.

  4. Misslinger M, Gsaller F, Hortschansky P, Muller C, Bracher F, Bromley MJ, Haas H. 2017. The cytochrome b5 CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus. Metallomics 9:1655-1665.

  5. Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Strassburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ. 2017. A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity. MBio 8.

  6. Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Muller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ. 2016. Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog 12:e1005775.

  7. Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Muhlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H. 2014. The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33:2261-76.

  8. Blatzer M, Gsaller F, Abt B, Schrettl M, Specht T, Haas H. 2014. An endogenous promoter for conditional gene expression in Acremonium chrysogenum: the xylan and xylose inducible promoter xyl1(P.). J Biotechnol 169:82-6.

  9. Gsaller F, Blatzer M, Abt B, Schrettl M, Lindner H, Haas H. 2013. The first promoter for conditional gene expression in Acremonium chrysogenum: iron starvation-inducible mir1(P). J Biotechnol 163:77-80.

  10. Grundlinger M, Gsaller F, Schrettl M, Lindner H, Haas H. 2013. Aspergillus fumigatus SidJ mediates intracellular siderophore hydrolysis. Appl Environ Microbiol 79:7534-6.

  11. Gsaller F, Eisendle M, Lechner BE, Schrettl M, Lindner H, Muller D, Geley S, Haas H. 2012. The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus. Metallomics 4:1262-70.

  12. Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jochl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H. 2010. HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6:e1001124.

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