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Cell-type specialization is encoded by specific chromatin topologies

Warren Winick-Ng1,22 ✉, Alexander Kukalev1,22, Izabela Harabula1,2,22, Luna Zea-Redondo1,2,22, Dominik Szabó1,2,22, Mandy Meijer3, Leonid Serebreni1,16, Yingnan Zhang4, Simona Bianco5, Andrea M. Chiariello5, Ibai Irastorza-Azcarate1, Christoph J. Thieme1, Thomas M. Sparks1, Sílvia Carvalho1,6,7,8, Luca Fiorillo5, Francesco Musella5, Ehsan Irani1,9, Elena Torlai Triglia1,17, Aleksandra A. Kolodziejczyk10,11,18, Andreas Abentung12,19, Galina Apostolova12, Eleanor J. Paul13,20,21, Vedran Franke14, Rieke Kempfer1,2, Altuna Akalin14, Sarah A. Teichmann10,11, Georg Dechant12, Mark A. Ungless13, Mario Nicodemi5,9, Lonnie Welch4, Gonçalo Castelo-Branco3,15 & Ana Pombo1,2,9 ✉

Winick-Ng, W., Kukalev, A., Harabula, I. et al. Cell-type specialization is encoded by specific chromatin topologies. Nature 599, 684–691 (2021). https://doi.org/10.1038/s41586-021-04081-2

SATB2-LEMD2 interaction link nuclear shape plasticity to regulation of cognition-related genes

Patrick Feurle^1*, Andreas Abentung^1*, Isabella Cera^1*, Nico Wahl^1*, Cornelia Ablinger¹, Michael Bucher², Eduard Stefan², Simon Sprenger³, David Teis³, Andre Fischer^4,5, Aodán Laighneach⁶, Laura Whitton⁶, Derek W. Morris⁶, Galina Apostolova^1# and Georg Dechant^1#

The EMBO journal 40 (3), e103701. DOI: 10.15252/embj.2019103701.

Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability.

Cera I, Whitton L, Donohoe G, Morris DW, Dechant G, Apostolova G.

PLoS Genet. 2019 Feb 6;15(2):e1007890. doi: 10.1371/journal.pgen.1007890. eCollection 2019 Feb.

Cocaine Paired Environment Increases SATB2 Levels in the Rat Paraventricular Thalamus.

Salti A, Apostolova G, Kummer KK, Lemos C, Dechant G, El Rawas R.

Front Behav Neurosci. 2018 Oct 2;12:224. doi: 10.3389/fnbeh.2018.00224. eCollection 2018.

Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment.

Whitton L, Apostolova G, Rieder D, Dechant G, Rea S, Donohoe G, Morris DW.

PLoS Genet. 2018 Jul 24;14(7):e1007515. doi: 10.1371/journal.pgen.1007515. eCollection 2018 Jul.

Bicistronic CACNA1A Gene Expression in Neurons Derived from Spinocerebellar Ataxia Type 6 Patient-Induced Pluripotent Stem Cells.

Bavassano C, Eigentler A, Stanika R, Obermair GJ, Boesch S, Dechant G, Nat R.

Stem Cells Dev. 2017 Nov 15;26(22):1612-1625. doi: 10.1089/scd.2017.0085. Epub 2017 Oct

Satb2 determines miRNA expression and long-term memory in the adult central nervous system.

Jaitner C, Reddy C, Abentung A, Whittle N, Rieder D, Delekate A, Korte M, Jain G, Fischer A, Sananbenesi F, Cera I, Singewald N, Dechant G, Apostolova G.

Elife. 2016 Nov 29;5. pii: e17361. doi: 10.7554/eLife.17361.

Reduced Anxiety-Like Behavior and Altered Hippocampal Morphology in Female p75NTR(exon IV-/-) Mice.

Puschban Z, Sah A, Grutsch I, Singewald N, Dechant G.

Front Behav Neurosci. 2016 Jun 1;10:103. doi: 10.3389/fnbeh.2016.00103

Social interaction reward decreases p38 activation in the nucleus accumbens shell of rats.

Salti A, Kummer KK, Sadangi C, Dechant G, Saria A, El Rawas R.

Neuropharmacology. 2015 Dec;99:510-6. doi: 10.1016/j.neuropharm.2015.08.029. Epub 2015 Aug 20.

Alternative generation of CNS neural stem cells and PNS derivatives from neural crest-derived peripheral stem cells.

Weber M, Apostolova G, Widera D, Mittelbronn M, Dechant G, Kaltschmidt B, Rohrer H.

Stem Cells. 2015 Feb;33(2):574-88. doi: 10.1002/stem.1880.

Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor.

Prast JM, Schardl A, Schwarzer C, Dechant G, Saria A, Zernig G.

Front Behav Neurosci. 2014 Sep 24;8:317. doi: 10.3389/fnbeh.2014.00317. eCollection 2014

Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.

Quarta S, Baeumer BE, Scherbakov N, Andratsch M, Rose-John S, Dechant G, Bandtlow CE, Kress M.

J Neurosci. 2014 Sep 24;34(39):13222-33. doi: 10.1523/JNEUROSCI.1209-13.2014.

Induced pluripotent stem cells from friedreich ataxia patients fail to upregulate frataxin during in vitro differentiation to peripheral sensory neurons.

Eigentler A, Boesch S, Schneider R, Dechant G, Nat R.

Stem Cells Dev. 2013 Dec 15;22(24):3271-82. doi: 10.1089/scd.2013.0126. Epub 2013 Aug 24.

Cell fate analysis of embryonic ventral mesencephalic grafts in the 6-OHDA model of Parkinson's disease.

Neto SC, Salti A, Puschban Z, Stefanova N, Nat R, Dechant G, Wenning GK.

PLoS One. 2012;7(11):e50178. doi: 10.1371/journal.pone.0050178. Epub 2012 Nov 29.

Acetylcholine, drug reward and substance use disorder treatment: intra- and interindividual striatal and accumbal neuron ensemble heterogeneity may explain apparent discrepant findings.

Prast JM, Kummer KK, Barwitz CM, Humpel C, Dechant G, Zernig G.

Pharmacology. 2012;90(5-6):264-73. doi: 10.1159/000342636. Epub 2012 Sep 25.

Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction.

El Rawas R, Klement S, Kummer KK, Fritz M, Dechant G, Saria A, Zernig G.

Front Behav Neurosci. 2012 Sep 24;6:63. eCollection 2012.

Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons.

Salti A, Nat R, Neto S, Puschban Z, Wenning G, Dechant G.

Stem Cells Dev. 2013 Feb 1;22(3):397-411. doi: 10.1089/scd.2012.0238. Epub 2012 Sep 20.

Identification of differentially expressed non-coding RNAs in embryonic stem cell neural differentiation.

Skreka K, Schafferer S, Nat IR, Zywicki M, Salti A, Apostolova G, Griehl M, Rederstorff M, Dechant G, Hüttenhofer A.

Nucleic Acids Res. 2012 Jul;40(13):6001-15. doi: 10.1093/nar/gks311. Epub 2012 Apr 6. Erratum in: Nucleic Acids Res. 2012 Oct;40(19):9980.

Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas.

El Rawas R, Klement S, Salti A, Fritz M, Dechant G, Saria A, Zernig G.

Front Behav Neurosci. 2012 Mar 2;6:8. doi: 10.3389/fnbeh.2012.00008. eCollection 2012.

Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development.

Nat R, Salti A, Suciu L, Ström S, Dechant G.

Stem Cells Dev. 2012 May 1;21(7):1016-46. doi: 10.1089/scd.2011.0271. Epub 2012 Feb 8.

p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.

Loy B, Apostolova G, Dorn R, McGuire VA, Arthur JS, Dechant G.

J Neurosci. 2011 Aug 24;31(34):12059-67. doi: 10.1523/JNEUROSCI.0448-11.2011.

Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats.

Fritz M, El Rawas R, Salti A, Klement S, Bardo MT, Kemmler G, Dechant G, Saria A, Zernig G.

Addict Biol. 2011 Apr;16(2):273-84. doi: 10.1111/j.1369-1600.2010.00285.x. Epub 2011 Feb 11.

Milestones of directed differentiation of mouse and human embryonic stem cells into telencephalic neurons based on neural development in vivo.

Nat R, Dechant G.

Stem Cells Dev. 2011 Jun;20(6):947-58. doi: 10.1089/scd.2010.0417. Epub 2011 Jan 31. Review.

The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2.

Apostolova G, Loy B, Dorn R, Dechant G.

J Neurosci. 2010 Dec 1;30(48):16356-64. doi: 10.1523/JNEUROSCI.3502-10.2010.

Development of neurotransmitter phenotypes in sympathetic neurons.

Apostolova G, Dechant G.

Auton Neurosci. 2009 Nov 17;151(1):30-8. doi: 10.1016/j.autneu.2009.08.012. Epub 2009 Sep 5. Review.

Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response.

Köllensperger M, Stefanova N, Pallua A, Puschban Z, Dechant G, Hainzer M, Reindl M, Poewe W, Nikkhah G, Wenning GK.

J Neurosci Res. 2009 May 15;87(7):1679-85. doi: 10.1002/jnr.21972.

The rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection.

Tuffereau C, Schmidt K, Langevin C, Lafay F, Dechant G, Koltzenburg M.

J Virol. 2007 Dec;81(24):13622-30. Epub 2007 Oct 10.

Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons.

Apostolova G, Dorn R, Ka S, Hallböök F, Lundeberg J, Liser K, Hakim V, Brodski C, Michaelidis TM, Dechant G.

Mol Cell Neurosci. 2007 Jul;35(3):397-408. Epub 2007 Apr 1.

Neurotrophic factors acutely alter the sorting of the vesicular acetyl choline transporter and the vesicular monoamine transporter 2 in bimodal sympathetic neurons.

Felder E, Dechant G.

Mol Cell Neurosci. 2007 Jan;34(1):1-9. Epub 2006 Oct 23.

The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons.

Zagrebelsky M, Holz A, Dechant G, Barde YA, Bonhoeffer T, Korte M.

J Neurosci. 2005 Oct 26;25(43):9989-99.

Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA.

Schweigreiter R, Walmsley AR, Niederöst B, Zimmermann DR, Oertle T, Casademunt E, Frentzel S, Dechant G, Mir A, Bandtlow CE.

Mol Cell Neurosci. 2004 Oct;27(2):163-74.

Antigen recognition properties of a Vgamma1.3Vdelta2-T-cell receptor from a rare variant of polymyositis.

Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H, Hohlfeld R.

J Neuroimmunol. 2004 Jul;152(1-2):168-75.

From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits.

Bandtlow C, Dechant G.

Sci STKE. 2004 May 25;2004(235):pe24. Review.

Regulation, cellular localization, and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons.

Gschwendtner A, Liu Z, Hucho T, Bohatschek M, Kalla R, Dechant G, Raivich G.

Mol Cell Neurosci. 2003 Oct;24(2):307-22.

Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases.

Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R.

Ann Neurol. 2003 Mar;53(3):292-304. Review.

Neurotrophins.

Dechant G, Neumann H.

Adv Exp Med Biol. 2002;513:303-34. Review.

The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system.

Dechant G, Barde YA.

Nat Neurosci. 2002 Nov;5(11):1131-6. Review.

Opposing functions of GDNF and NGF in the development of cholinergic and noradrenergic sympathetic neurons.

Brodski C, Schaubmar A, Dechant G.

Mol Cell Neurosci. 2002 Apr;19(4):528-38.

Therapy of neurodegenerative diseases using neurotrophic factors: cell biological perspective.

Brodski C, Vogt Weisenhorn DM, Dechant G.

Expert Rev Neurother. 2002 May;2(3):417-26. doi: 10.1586/14737175.2.3.417.

Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons.

Naumann T, Casademunt E, Hollerbach E, Hofmann J, Dechant G, Frotscher M, Barde YA.

J Neurosci. 2002 Apr 1;22(7):2409-18.

Chat in the trophic web: NGF activates Ret by inter-RTK signaling.

Dechant G.

Neuron. 2002 Jan 17;33(2):156-8.

Institute for Neuroscience - Gemeinsame Einrichtung für Neurowissenschaften