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Neurophysiology of calcium channels  

 

Scientific publications

 

  1. Wegleiter, K., Hermann, M., Posod, A., Wechselberger, K., Stanika, R.I., Obermair, G.J., Kiechl-Kohlendorfer, U., Urbanek, M., and Griesmaier, E., The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo. Exp Neurol, 2014. 261: p. 501-9. http://www.ncbi.nlm.nih.gov/pubmed/25111531
  2. Etemad, S., Campiglio, M., Obermair, G.J., and Flucher, B.E., The juvenile myoclonic epilepsy mutant of the calcium channel beta subunit displays normal nuclear targeting in nerve and muscle cells. Channels (Austin), 2014. 8(4). http://www.ncbi.nlm.nih.gov/pubmed/24875574
  3. Griesmaier, E., Stock, K., Medek, K., Stanika, R.I., Obermair, G.J., Posod, A., Wegleiter, K., Urbanek, M., and Kiechl-Kohlendorfer, U., Levetiracetam increases neonatal hypoxic-ischemic brain injury under normothermic, but not hypothermic conditions. Brain Res, 2014. 1556: p. 10-8. http://www.ncbi.nlm.nih.gov/pubmed/24530252
  4. Etemad, S., Obermair, G.J., Bindreither, D., Benedetti, A., Stanika, R., Di Biase, V., Burtscher, V., Koschak, A., Kofler, R., Geley, S., Wille, A., Lusser, A., Flockerzi, V., and Flucher, B.E., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci, 2014. 34(4): p. 1446-61. http://www.ncbi.nlm.nih.gov/pubmed/24453333
  5. Koenig, X., Rubi, L., Obermair, G.J., Cervenka, R., Dang, X.B., Lukacs, P., Kummer, S., Bittner, R.E., Kubista, H., Todt, H., and Hilber, K., Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart. Am J Physiol Heart Circ Physiol, 2014. 306(4): p. H564-73. http://www.ncbi.nlm.nih.gov/pubmed/24337461
  6. Daschil, N., Geisler, S., Obermair, G.J., and Humpel, C., Short- and long-term treatment of mouse cortical primary astrocytes with beta-amyloid differentially regulates the mRNA expression of L-type calcium channels. Pharmacology, 2014. 93(1-2): p. 24-31. http://www.ncbi.nlm.nih.gov/pubmed/24435206
  7. Kern, F., Stanika, R.I., Sarg, B., Offterdinger, M., Hess, D., Obermair, G.J., Lindner, H., Bandtlow, C.E., Hengst, L., and Schweigreiter, R., Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress. Biochem J, 2013. 455(2): p. 217-27. http://www.ncbi.nlm.nih.gov/pubmed/23909438
  8. Knoflach, D., Kerov, V., Sartori, S.B., Obermair, G.J., Schmuckermair, C., Liu, X., Sothilingam, V., Garrido, M.G., Baker, S.A., Glosmann, M., Schicker, K., Seeliger, M., Lee, A., and Koschak, A., Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2. Channels (Austin), 2013. 7(6): p. 503-13. http://www.ncbi.nlm.nih.gov/pubmed/24051672
  9. Nimmervoll, B., Flucher, B.E., and Obermair, G.J., Dominance of P/Q-type calcium channels in depolarization-induced presynaptic FM dye release in cultured hippocampal neurons. Neuroscience, 2013. 253: p. 330-40. http://www.ncbi.nlm.nih.gov/pubmed/24012836
  10. Daschil, N., Obermair, G.J., Flucher, B.E., Stefanova, N., Hutter-Paier, B., Windisch, M., Humpel, C., and Marksteiner, J., CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-beta plaques in an Alzheimer's disease mouse model. J Alzheimers Dis, 2013. 37(2): p. 439-51. http://www.ncbi.nlm.nih.gov/pubmed/23948887
  11. Hausott, B., Vallant, N., Schlick, B., Auer, M., Nimmervoll, B., Obermair, G.J., Schwarzer, C., Dai, F., Brand-Saberi, B., and Klimaschewski, L., Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons. Hippocampus, 2012. 22(3): p. 434-41. http://www.ncbi.nlm.nih.gov/pubmed/21240919
  12. Di Biase, V., Tuluc, P., Campiglio, M., Obermair, G.J., Heine, M., and Flucher, B.E., Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons. J Neurosci, 2011. 31(38): p. 13682-94. http://www.ncbi.nlm.nih.gov/pubmed/21940459
  13. Schlick, B., Flucher, B.E., and Obermair, G.J., Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience, 2010. 167(3): p. 786-98. http://www.ncbi.nlm.nih.gov/pubmed/20188150
  14. Gebhart, M., Juhasz-Vedres, G., Zuccotti, A., Brandt, N., Engel, J., Trockenbacher, A., Kaur, G., Obermair, G.J., Knipper, M., Koschak, A., and Striessnig, J., Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule. Mol Cell Neurosci, 2010. 44(3): p. 246-59. http://www.ncbi.nlm.nih.gov/pubmed/20363327
  15. Obermair, G.J., Schlick, B., Di Biase, V., Subramanyam, P., Gebhart, M., Baumgartner, S., and Flucher, B.E., Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons. J Biol Chem, 2010. 285(8): p. 5776-91. http://www.ncbi.nlm.nih.gov/pubmed/19996312
  16. Jenkins, M.A., Christel, C.J., Jiao, Y., Abiria, S., Kim, K.Y., Usachev, Y.M., Obermair, G.J., Colbran, R.J., and Lee, A., Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J Neurosci, 2010. 30(15): p. 5125-35. http://www.ncbi.nlm.nih.gov/pubmed/20392935
  17. Subramanyam, P., Obermair, G.J., Baumgartner, S., Gebhart, M., Striessnig, J., Kaufmann, W.A., Geley, S., and Flucher, B.E., Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells. Channels (Austin), 2009. 3(5): p. 343-55. http://www.ncbi.nlm.nih.gov/pubmed/19755859
  18. Di Biase, V., Flucher, B.E., and Obermair, G.J., Resolving sub-synaptic compartments with double immunofluorescence labeling in hippocampal neurons. J Neurosci Methods, 2009. 176(2): p. 78-84. http://www.ncbi.nlm.nih.gov/pubmed/18805439
  19. Tuluc, P., Molenda, N., Schlick, B., Obermair, G.J., Flucher, B.E., and Jurkat-Rott, K., A CaV1.1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle. Biophys J, 2009. 96(1): p. 35-44. http://www.ncbi.nlm.nih.gov/pubmed/19134469
  20. Sinnegger-Brauns, M.J., Huber, I.G., Koschak, A., Wild, C., Obermair, G.J., Einzinger, U., Hoda, J.C., Sartori, S.B., and Striessnig, J., Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol, 2009. 75(2): p. 407-14. http://www.ncbi.nlm.nih.gov/pubmed/19029287
  21. Watschinger, K., Horak, S.B., Schulze, K., Obermair, G.J., Wild, C., Koschak, A., Sinnegger-Brauns, M.J., Tampe, R., and Striessnig, J., Functional properties and modulation of extracellular epitope-tagged Ca(V)2.1 voltage-gated calcium channels. Channels (Austin), 2008. 2(6): p. 461-73. http://www.ncbi.nlm.nih.gov/pubmed/18797193
  22. Obermair, G.J., Tuluc, P., and Flucher, B.E., Auxiliary Ca(2+) channel subunits: lessons learned from muscle. Curr Opin Pharmacol, 2008. 8(3): p. 311-8. http://www.ncbi.nlm.nih.gov/pubmed/18329337
  23. Di Biase, V., Obermair, G.J., Szabo, Z., Altier, C., Sanguesa, J., Bourinet, E., and Flucher, B.E., Stable membrane expression of postsynaptic CaV1.2 calcium channel clusters is independent of interactions with AKAP79/150 and PDZ proteins. J Neurosci, 2008. 28(51): p. 13845-55. http://www.ncbi.nlm.nih.gov/pubmed/19091974
  24. Letschka, T., Kollmann, V., Pfeifhofer-Obermair, C., Lutz-Nicoladoni, C., Obermair, G.J., Fresser, F., Leitges, M., Hermann-Kleiter, N., Kaminski, S., and Baier, G., PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood, 2008. 112(12): p. 4617-27. http://www.ncbi.nlm.nih.gov/pubmed/18796635
  25. Tuluc, P., Kern, G., Obermair, G.J., and Flucher, B.E., Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A, 2007. 104(26): p. 11091-6. http://www.ncbi.nlm.nih.gov/pubmed/17563358
  26. Koschak, A., Obermair, G.J., Pivotto, F., Sinnegger-Brauns, M.J., Striessnig, J., and Pietrobon, D., Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells. J Neurosci, 2007. 27(14): p. 3855-63. http://www.ncbi.nlm.nih.gov/pubmed/17409250
  27. Szabo, Z., Obermair, G.J., Cooper, C.B., Zamponi, G.W., and Flucher, B.E., Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neurons. Eur J Neurosci, 2006. 24(3): p. 709-18. http://www.ncbi.nlm.nih.gov/pubmed/16930401
  28. Schredelseker, J., Di Biase, V., Obermair, G.J., Felder, E.T., Flucher, B.E., Franzini-Armstrong, C., and Grabner, M., The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle. Proc Natl Acad Sci U S A, 2005. 102(47): p. 17219-24. http://www.ncbi.nlm.nih.gov/pubmed/16286639
  29. Obermair, G.J., Kugler, G., Baumgartner, S., Tuluc, P., Grabner, M., and Flucher, B.E., The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling. J Biol Chem, 2005. 280(3): p. 2229-37. http://www.ncbi.nlm.nih.gov/pubmed/15536090
  30. Flucher, B.E., Obermair, G.J., Tuluc, P., Schredelseker, J., Kern, G., and Grabner, M., The role of auxiliary dihydropyridine receptor subunits in muscle. J Muscle Res Cell Motil, 2005. 26(1): p. 1-6. http://www.ncbi.nlm.nih.gov/pubmed/16088377
  31. Obermair, G.J., Szabo, Z., Bourinet, E., and Flucher, B.E., Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons. Eur J Neurosci, 2004. 19(8): p. 2109-22. http://www.ncbi.nlm.nih.gov/pubmed/15090038
  32. Obermair, G.J., Kugler, G., and Flucher, B.E., The role of the calcium channel alpha 2 delta-1 subunit in skeletal muscle. J Muscle Res Cell Motil, 2004. 25(3): p. 239-40. http://www.ncbi.nlm.nih.gov/pubmed/15467389
  33. Kasielke, N., Obermair, G.J., Kugler, G., Grabner, M., and Flucher, B.E., Cardiac-type EC-coupling in dysgenic myotubes restored with Ca2+ channel subunit isoforms alpha1C and alpha1D does not correlate with current density. Biophys J, 2003. 84(6): p. 3816-28. http://www.ncbi.nlm.nih.gov/pubmed/12770887
  34. Obermair, G.J., Kaufmann, W.A., Knaus, H.G., and Flucher, B.E., The small conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons. Eur J Neurosci, 2003. 17(4): p. 721-31. http://www.ncbi.nlm.nih.gov/pubmed/12603262
  35. Pragl, B., Koschak, A., Trieb, M., Obermair, G., Kaufmann, W.A., Gerster, U., Blanc, E., Hahn, C., Prinz, H., Schutz, G., Darbon, H., Gruber, H.J., and Knaus, H.G., Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels. Bioconjug Chem, 2002. 13(3): p. 416-25. http://www.ncbi.nlm.nih.gov/pubmed/12009929
  36. Dittus, J., Cooper, S., Obermair, G., and Pulakat, L., Role of the third intracellular loop of the angiotensin II receptor subtype AT2 in ligand-receptor interaction. FEBS Lett, 1999. 445(1): p. 23-6. http://www.ncbi.nlm.nih.gov/pubmed/10069367

 

 

Books and book chapters

 

Obermair GJ, Flucher BE (2013) Neuronal functions of auxiliary calcium channel subunits. In Modulation of Presynaptic Calcium Channels, Stephens G, Mochida S, Eds. Springer,  pp. 365. [link: http://www.springer.com/biomed/book/978-94-007-6333-3]

 

 Minnich B, Obermair GJ, Deacon S (2001): Chronobiology and Chronic Rheumatism: Effects of Radon-Balneotherapy and Melatonin Treatment within Chronic Arthrosis, Reports of the Research Institute Gastein - Tauernregion, Lang - Europäischer Verlag der Wissenschaften, Vol. 4: 186pp.

 

Gerald Obermair

 

 neuron.jpg

 

Gerald Obermair,
Division of Physiology
Dept. Physiology and Medical Physics
Medical University of Innsbruck
Schöpfstrasse 41
6020 Innsbruck, Austria.
Phone: +43 512 9003 70841
Gerald.Obermair@i-med.ac.at

 

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 neuron.jpg

 

Gerald Obermair,
Division of Physiology
Dept. Physiology and Medical Physics
Medical University of Innsbruck
Schöpfstrasse 41
6020 Innsbruck, Austria.
Phone: +43 512 9003 70841
Gerald.Obermair@i-med.ac.at

 

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