Renal Epithelial Cell Physiology - Team Jennings
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Priv. Doz. Dr. Paul Jennings PhD p.jennings@vu.nl
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Paul Jennings is currently an Assistant Professor at the Division of Physiology, Medical University of Innsbruck. He completed his PhD in 2001 in the field of in vitro nephrotoxicity. His research is focused to understanding the molecular mechanisms of chemical induced nephrotoxicity with a strong focus on stress response pathways including but not limited to Nrf2, unfolded protein response and p53. Current models employed in his laboratory include primary human proximal tubule (PT) cells, telomerase immortalised human PT cells (RPTEC/TERT1) and human iPSC derived PT and podocyte cells. His laboratory is experienced in integrated omic analysis and biokinetics. Dr. Jennings’ research group is an integral member of several key European Projects which aim to improve drug safety assessment regimes including, Predict-IV, DETECTIVE, StemBANCC and EUToxRisk. Links: Pubmed, Google Scholar, Research Gate |
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Dr. Anja Wilmes anja.wilmes@i-med.ac.at
Anja Wilmes graduated with a Diplom in “Biology” from the University of Heidelberg, Germany in 2004. She then completed her PhD thesis in “Cell and Molecular Biology” in 2008 at Victoria University of Wellington, New Zealand under the supervision of Prof. John Miller. Her PhD thesis was entitled “Differences in Mode of Action between Peloruside A and Paclitaxel, two Microtubule Stabilizing Agents”. She joined Pauls Jenning’s group as a PostDoc in 2009. Her work focuses on identifying cellular stress response pathways, including Nrf2-mediated oxidative stress response, in renal proximal tubular cells, as well as epithelial tight junction regulation. Anja is also working on developing renal differentiation strategies of induced pluripotent stem cells as part of the StemBANCC project. Links: Pubmed, Google Scholar, Research Gate |
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Dr. Alice Limonciel
Alice Limonciel studied the life sciences at the University of Nice - Sophia-Antipolis, France, for two years before entering the engineer school Polytech’ Nice-Sophia in 2005. In the school, she first studied the general principles of pharmacology before opting for a toxicology specialisation. During her 3-year engineer training, Alice gained practical experience in several research laboratories in Europe: LCMBA, Antiviral – Antitumor group, Nice, France (2006), IRAS, Molecular and Cellular Toxicology, Utrecht, the Netherlands (2007) and Bayer CropScience, Toxicology Research Unit, Sophia-Antipolis, France (2008). She graduated with an Engineer degree (equivalent to MSc.) in "Toxicology and Health and Environment Security" in 2008. Alice completed her PhD in the Renal group of the Department of Physiology and Medical Physics of Innsbruck Medical University in October 2013 under the supervision of Paul Jennings, entitled "Characterisation of the molecular stress responses of cultured human renal proximal tubule cells exposed to industrial and pharmaceutical nephrotoxins". She is continuing this work as a PostDoc in the DETECTIVE project. Links: Pubmed, Google Scholar, Research Gate |
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Mag. Giada Carta Giada Carta graduated with a bachelor in Cellular and Molecular Biology at the University of Rome “Tor Vergata” in 2012 with a neuroscience based experimental thesis performed at the Medical University of Innsbruck under the supervision of Univ.-Prof. Dr. med. Hans-Günther Knaus at the Division of Cellular and Molecular Pharmacology. She continued her studies at the Leopold-Franzens-University in Innsbruck, and graduated with a Master in Cell Molecular and Developmental biology in 2015. In 2016 she started her PhD in the Molecular Cell Biology program under the supervision of Ass. Prof. Priv.-Doz. Dr. Paul Jennings in the renal group at the Division of Physiology of the Medical University Innsbruck. Her study focuses on the prediction and modelling of chemical induced chronic diseases utilizing state-of-the-art in vitro models as part of the EU-ToxRisk21 project. Links: Pubmed |
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Mag. Georg Kern Room 147 Phone: +43 512 9003 70804 Georg.Kern@i-med.ac.at
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Previous Lab Members |
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Dr. Lydia Aschauer completed her PhD at the Physiology Department of the Innsbruck Medical University in December 2013 . The title of her PhD thesis is "Characteristion of renal epithelial maturation processes and their role in compound-induced cellular stress". Links: Pubmed, Google Scholar, Research Gate |
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Dr. Med. Sinikka Prajczer PhD. Sinikka graduated with a PhD thesis in 2012, entitled "Investigation of immune mechanisms in uromodulin-assosiated kidney disease". Link: Pubmed |
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Dr. Sara Signorelli. Sara graduated from our lab with a PhD thesis in 2010 entitled "Development of in vitro systems of the pulmonary alveolus for the investigation of hypoxia-induced cell survival strategies." Link Pubmed. |
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Dr. Sonia Aydin. Sonia graduated from our lab in 2010. Her PhD thesis was entitled "Development of in vitro models for the investigation of chronic renal disease". Link Pubmed. |
