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Experimentelle Alzheimerforschung

Univ.-Prof. Mag. Dr. Christian Humpel

Leitung

 

Forschungsschwerpunkte:

Wir interessieren uns dafür, warum bei der Alzheimerdemenz die pathologischen Ablagerungen im Gehirn entstehen und wie diese verhindert werden können, und auch, warum Nervenzellen absterben. Weiters wollen wir Biomarker in humanen Flüssigkeiten zur Diagnose finden.

Aktuelle Projekte (auch online):

Ausbreitung der Alzheimerdemenz in Gehirnschnitten (FWF P32558)
Analyse von Alzheimermarkern im Liquor (Routinediagnostik)
Neue Biomarker im Speichel
Gehirnschnitte und Microcontact printing als Modell eines „brain-on-a-chip“

Mitarbeiter:

Anna Draxl, BMA
Mohadeseh Ragerdikashani, BMA
Dhwani Korde, MSc
Katharina Steiner, MSc

Aktuelle Publikationsliste (Auszug):

Züricher C and Humpel C (2023) Saliva: a challenging human fluid to diagnose brain disorders with a focus on Alzheimer's disease. Neural Regen Res 18:2606-2610.

Steiner K and Humpel C (2023) Long-term organotypic brain slices cultured on collagen-based microcontact prints: A perspective for a brain-on-a-chip. J Neurosci Methods 1:399:109979.

Grazia Ilaria C, Korde D, Humpel C (2023) Melatonin Supports the Survival of Cholinergic Neurons in Organotypic Brain Slices of the Basal Nucleus of Meynert. Pharmacology 108:204-212.

Steiner K and Humpel C (2022) Effects of ischemia on the migratory capacity of microglia along collagen microcontact prints on organotypic mouse cortex brain slices. Front Cell Neurosci 16:16:858802.

Humpel C (2022) Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail? Neural Regen Res 17:1881-1884.

Marksteiner J, Defrancesco M, Humpel C (2022) Saliva tau and phospho-tau-181 measured by Lumipulse in patients with Alzheimer's disease. Front Aging Neurosci 29:14:1014305.

Korde W and Humpel C (2022) Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures. Biomolecules 12:1164.

Korde D, Humpel C (2022) Western Agarose Native GeELution (WANGEL) with beta-amyloid and tau: Novel method to elute proteins or peptides using native agarose gels followed by Lumipulse assay. MethodsX 6:101779.

Sarg B, Korde D, Marksteiner J, Humpel C (2022) Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease. Front Biosci (Landmark Ed) 27:153.

Uçar B, Stefanova N, Humpel C (2022) Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices. Biomolecules 12:163.

 

Forschung