Division für Molekulare & Zelluläre Pharmakologie

Publications (Division)

2011
     
101.

Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus HG, D'Orsi B, Prehn JH, Eisel UL, Plant T, Plesnila N, Culmsee C.KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis. 2011 Apr 21;2:e147.

 

2010
100.

Jeffries O, Geiger N, Rowe IC, Tian L, McClafferty H, Chen L, Bi D, Knaus HG, Ruth P, Shipston MJ. Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. J Biol Chem. 2010 Oct 22;285(43):33307-14.

 
99.

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U. Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):14950-7.

 
98.

Chen X, Kovalchuk Y, Adelsberger H, Henning HA, Sausbier M, Wietzorrek G, Ruth P, Yarom Y, Konnerth A. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12323-8

 
97.

Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, Knaus HG, Marksteiner J. L-type calcium channel CaV 1.2 in

transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations. J Alzheimers Dis. 2010;20(4):1167-80.

 
96.

Chen L, Jeffries O, Rowe IC, Liang Z, Knaus HG, Ruth P, Shipston MJ. Membrane trafficking of large conductance calcium-activated potassium channels is
regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem. 2010 Jul 23;285(30):23265-75.

 
95.

Oliveira MS, Skinner F, Arshadmansab MF, Garcia I, Mello CF, Knaus HG, Ermolinsky BS, Otalora LF, Garrido-Sanabria ER. Altered expression and function

of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain Res. 2010 Aug 12;1348:187-99

 
 2009
94.

Kaufmann WA, Ferraguti F, Fukazawa Y, Kasugai Y, Shigemoto R, Laake P, Sexton JA, Ruth P, Wietzorrek G, Knaus HG, Storm JF, Ottersen OP. Large-conductance
calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains. J Comp Neurol. 2009 Jul
10;515(2)

 
93.

Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W. Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier. J Neurochem. 2009 Feb;108(3):707-18.

 
2008
92.

Tian L, Jeffries O, McClafferty H, Molyvdas A, Rowe IC, Saleem F, Chen L, Greaves J, Chamberlain LH, Knaus HG, Ruth P, Shipston MJ. Palmitoylation gates
phosphorylation-dependent regulation of BK potassium channels. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):21006-11.

 
91.

Dolga AM, Granic I, Blank T, Knaus HG, Spiess J, Luiten PG, Eisel UL, Nijholt IM. TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity
via NF-kappaB-dependent up-regulation of K2.2 channels. J Neurochem. 2008 Nov;107(4):1158-67.

 
90.

Willis M, Prokesch M, Hutter-Paier B, Windisch M, Stridsberg M, Mahata SK, Kirchmair R, Wietzorrek G, Knaus HG, Jellinger K, Humpel C, Marksteiner J.
Chromogranin B and Secretogranin II in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations and in
Alzheimer patients. J Alzheimers Dis. 2008 Mar;13(2):123-35.

89.

Pacheco Otalora LF, Hernandez EF, Arshadmansab MF, Francisco S, Willis M, Ermolinsky B, Zarei M, Knaus HG, Garrido-Sanabria ER. Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy. Brain Res. 2008 Mar 20;1200:116-31.

 2007
88.

Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus HG, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D. Presence
of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia. Brain Pathol. 2007 Oct;17(4):389-98.

 
87. Brunton, B.J., Sausbier, M., Wietzorrek, J., Sausbier, U., Knaus, H.G., Russel, J.A., Ruth,, P. & Shipston, M.J.: HPA axis hyporesponsiveness to restraint stress in mice deficient for large-conductance, voltage- and calcium-dependent potassium (BK) channel; Endocrinology, in press (2007) [PubMed]
86. Derfuss, T., Segerer, S., Herberger, S., Sinicina, I., Huefner, K., Ebelt, K., Knaus, H.G., Steiner, I., Meinl, E., Dornmair, K., Arbusow, V., Strupp, M., Brandt, T. & Theil, D.: Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia; Brain Pathol., in press (2007) [PubMed]
85. Zarei, M.M., Song, M., Wilson, R., Cox, M., Colom, L., Knaus, H.G., Stefani, E. & Toro, L.: Endocytic trafficking signals in KCNMB2 regulate surface xxpression of a voltage and Ca2+-activated K+ channel; Neuroscience 147, 80-89 (2007) [PubMed]
84. Willis, M., Hutter-Paier, B., Wietzorrek, G., Windisch, M., Humpel, C., Knaus, H.G. & Marksteiner, J.: Localisation and expression of substance P in transgenic mice overexpressing human APP751 with the London (V171) and Swedish (K670M/N671L) mutations; Brain Res. 1143, 199-207 (2007) [PubMed]

2006
83. Beeton, C., Wulff, H., Stadifer, N.E., Azam, P., Mullen, K., Pennington, M., Kolski-Andreaco, A., Wei, E., Grino, A., Counts, D.R., Wang, P., LeeHealey, C., Andrews, P., Sankaranarayanan, A., Homerick, D., Roeck, W.W., Tehranzadeh, J., Stanhope, K.L., Zimin, P., Havel, P.J., Griffey, S., Knaus, H.G., Nepom, G., Gutman, G., Calabresi, P. & Chandy, K.G.: Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases; Proc. Natl. Acad. Sci. U.S.A., 103, 17414-17419 (2006) [PubMed]
82. Tian, L., McClafferty, H., Sailer, C.A., Ruth, P., Knaus, H.-G. & Shipston, M.J.: Non-canoical SH3 domain binding motif targets multiple adapter proteins to large-conductance Ca2+-actiavted (BK) K+ channel; FASEB J., in press (2006) [PubMed]
81. Berkefeld, H., Sailer, C.A., Bidl, W., Thumfart, J.O., Rhode, V., Eble, S., Klugbauer, N., Reisinger, E., Bischofberger, J., Oliver, D., Knaus, H.G., Schulte, U. & Fakler B.: BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signalling; Science 314, 615-620 (2006) [PubMed]
80. Sailer, C.A., Kaufmann, W.A., Kogler, M., Chen, L., Sausbier, U., Ottersen, O.P., Ruth, P., Shipston, M.J. & Knaus, H.G.: Immunolocalisation of BK channels in hippocampal pyramidal neurons; Eur. J. Neurosci. 24, 442-454 (2006) [PubMed]
79. Macdonald, S.H., Ruth, P., Knaus, H.G. & Shipston, M.J.: Increased large-conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the devoloping mouse CNS; BMC Dev. Biol. 27, 1-6 (2006) [PubMed]
78. Liu, C.J., Priest, B.T., Bugianesi, R.M., Dulski, B.M., Dick, I.E., Brochu, R.M., Knaus, H.G., Middelton, R.E., Kaczorowski, G.J., Slaughter, R.S., Garcia, M.L. & Kohler, M.G.: A high capacity functional assay for Nav1.8 channel using membrane potential FRET-based assay on a FLIPR Tetra instrument; Assay Drug Dev. Technol. 4, 37-48 (2006) [PubMed]
77. Schulte, U., Thumfart, J.O., Kloecker, N., Sailer, C.A., Bildl, W., Biniossek, M., Dehn D., Deller, T., Eble, S., Abbass, K., Wangler, T., Knaus, H.G. & Fakler, B.: The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvß1 subunits; Neuron 49, 697-706 (2006) [PubMed]
76. Sausbier, U., Sausbier, M. Sailer, C.A., Arntz, C., Knaus, H.G., Neuhuber, W. & Ruth, P.: Ca2+-activated K+ channels of the BK-type in mouse brain; Histochem. Cell. Biol. 125, 725-741 (2006) [PubMed]

2005
75. Chen, L., Tian, L., McDonald, S.H.F., McClafferty, H., Hammond, M.S.L., Huibant, J.-M., Ruth, P., Knaus, H.G. & Shipston, M.J.: Funcionally diverse complement of calcium-activated BK channel alpha-subunits generated from a single site of splicing; J. Biol. Chem. 280, 33599-33609 (2005) [PubMed]
74. Rus, H., Pardo, C.A., Hu, L., Darrah, E., Cudrici, C., Niculescu, T., Niculescu, F., Mullen, K.M., Allie, R., Guo, L., Wulff, H., Beeton, C., Judge, S.I.V., Kerr, D.A., Knaus, H.G., Chandy, K.G. & Calabresi, P.A.: The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain; Proc. Natl. Acad. Sci. U.S.A. 102, 11094-11099 (2005) [PubMed]
73. Schmalhofer, W.A., Sanchez, M., Dewan, A., Secades, L., Hanner, M., Knaus, H.G., McManus, O.B., Kohler, M., Kaczorowski, G.J. & Garcia, M.L.: The C-terminus domain of the high-conductance calcium-activated potassium channel: role in channel structure and function; Biochemistry 44, 11135-11144 (2005) [PubMed]
72. Strassmaier, T., Bond, C.T., Sailer, C.A., Knaus, H.G., Maylie, J. & Adelman, J.P.: A novel isoform of SK2 assembles with other SK subunits in mouse brain; J. Biol. Chem. 280, 21231-21236 (2005) [PubMed]
71. Sausbier, M., Arntz, C., Bucurenciu, I., Feil, S., Zhao, H., Sausbier, U., Kamm, S., Zhou, X.P., Essin, K., Sailer, C.A., Krippeit-Drews, P., Feil, R., Hofmann, F., Knaus, H.G., Kenyon, M., Shipston, M.J., Storm, J.F., Neuhuber, W., Korth, M., Schubert, R., Gollasch, M. & Ruth, P.: Elevated blood pressure linked to primary hyperaldosteronism and impared vasodilation in BK channel deficient mice; Circulation 112, 60-68 (2005)

[Pubmed]


2004
70. Tian, L., Coghill, L.S., McClafferty H.N., MacDonald, H.-F., Antoni, F., Ruth, P., Knaus, H.G. & Shipston, M.J.: Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A.  101, 11897-11902 (2004)

[PubMed]

69. Wulff, H., Pennington, M., Knaus, H.G. & Chandy K.G.: K+ channel expression after B- and T-cell differentiation: implications for immunotherapy and autoimmunity. J. Immunol. 173, 776-786 (2004) [PubMed]
68. Zarei, M.M., Eghbali, M., Alioua, A., Song, M., Knaus, H.G., Stefani, E. & Toro L.: A novel ER trafficking signal prevents surface expression of a voltage and Ca2+-activated K+ channel splice variant. Proc. Natl. Acad. Sci. U.S.A. 101, 10072-10077 (2004)

[PubMed]

67. Sausbier, M., Arntz, C., Feil, S., Hu, H., Zhao, H., Kamm, S., Bucurenciu, I., Adelsberger, H., Essin, K., Zhou, X.-B., Sausbier, U., Sailer, C.A., Krippeit-Drews, R., Feil, F., Hoffmann, F., Shipston, M.J., Korth, M., Knaus, H.G., Wolfer, D., Schubert, R., Gollasch, M., Pedroarena, C., Storm, J.F. & Ruth, P.: Cerebellar disorders linked to BK channel deficiency. Proc. Natl. Acad. Sci. U.S.A.  101, 9474-9478 (2004)

[PubMed]

xi. Stephens, F., Zhou, X.B., Sausbier, U., Sailer, C.A., Motejlek, K., Ruth, P., Olcese, J., Korth, M. & Wieland, T.: Melatonin receptor signaling in pregnant and nonpregnant rat uterine myocytes as probed by large conductance Ca2+-activated K+ channel activity. Mol. Endocrinol. 17, 2103-2115 (2004)

[PubMed]

x. Matthes, J., Yildirim, L., Wietzorrek, G., Reimer, D., Striessnig, J. & Herzig, S.: Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Ca(v)1.3-knockout mice. Naunyn Schmiedebergs Arch. Pharmacol. 369, 554-562 (2004) [PubMed]
66. Shakkottai, V.G., Chou, C.H., Oddo, S., Sailer, C.A., Knaus, H.G., Gutman, G.A., Barish, M.E., LaFerla, F.M. & Chandy, K.G.: Silencing SK channels in deep cerebellar nuclei: a transgenic model for human cerebellar ataxia. J. Clin. Invest. 113, 582-590 (2004)

[PubMed]

ix. Sinneggerbrauns, M.J., Hetzenauer, A., Huber, I.G., Renstrom, E., Wietzorrek, G., Berjukov, S., Cavalli, M., Walter, D., Koschak, A., Waldschutz, R., Hering, S., Bova, S., Rorsman, P., Pongs, O., Singewald, N. ; Striessnig J.: Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca(2+) channels. J. Clin. Invest. 113, 1430-1439 (2004)

[PubMed]

65. Rasmussen, H.B., Moller, M., Knaus, H.G., Jensen, B.S., Olesen, S.-P. & Jorgensen, N.K.: Subcellular localization of the delayed rectifier potassium channel KCNQ1 and ERG1 in rat heart. Am.J.Physiol. (Heart Circ. Physiol) 286, H1300-1309 (2004)

[PubMed]

64. Sailer, C.A., Kaufmann, W.A., Marksteiner, J. & Knaus, H.G.: Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain; Mol. Cell. Neurosci. 26, 458-469 (2004)

[PubMed]


2003
viii. Steffens, F., Zhou, B.-F., Sausbier, U., Sailer, C.A., Motejlek, K., Ruth, P., Olcese, J., Korth, M. & Wieland, T.: Melatonin receptor signalling in pregnant and nonpregnant rat uterine myocytes as probed by large-conductance Ca2+-activated K+ channels. Mol. Endocrinol. 17, 2103-2115 (2003)

[PubMed]

63. Angelo, K., Korolkova, Y., Grunnet, M., Grishin, E.V., Klaerke, D.A., Knaus, H.G., Moller, M. & Olesen, S.P.: A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1. Pflugers Arch. Eur. J. Physiol. 447, 55-63 (2003)

[PubMed]

62. Hay-Schmid, A., Grunnet, M., Abrahamse, S.L., Knaus, H.G. & Klaerke, D.: Localisation of Ca2+-activated big-conductance K+ channels in rabbit distal colon; Pflugers Arch. Eur. J. Physiol. 446, 61-68 (2003)

[PubMed]

vii. Glueckert, R., Wietzorrek, G., Kammen-Jolly, K., Scholtz, A., Stephan, K., Striessnig, J. & Schrott-Fischer, A.: Role of class D L-type Ca2+-channels for normal cochlear morphology. Hearing Res. 78, 95-105 (2003) [PubMed]
vi. Moebius, F.F., Fitzky, B.U., Wietzorrek, G., Haidekker, A., Eder, A. & Glossmann, H.: Cloning of an EBP like protein that lacks sterol delta8/-delta7 isomerase activity. Biochem. J. 374, 229-237 (2003)

[PubMed]

v. Clark, N., Nagano, N., Kuenzi, F.M., Jarolimek, W., Huber, I., Walter, D., Wietzorrek., G., Boyce, S., Kullmann, D.M., Striessnig, J. & Seabrook GR.: Neurological phenotype and synaptic function in mice lacking the CaV1.3 alpha subunit of neuronal L-type voltage-dependent Ca2+ channels. Neuroscience 120, 435-442 (2003)

[PubMed]

61. Obermair, G.J., Kaufmann; W.A., Knaus, H.G. & Flucher, B.F.: The small-conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons; Eur. J. Neurosci. 17, 721-731 (2003)

[PubMed]


2002
60. Freudenthaler, G., Axmann, M., Schindler, H., Pragl, B., Knaus, H.G. and Schütz, G.J.: Ultrasensitive pharmacological characterisation of the voltage-gated potassium channel Kv1.3 studied by single-molecule microscopy. Histochem. Cell. Biol. 117, 197-202 (2002)

[PubMed]

59. Sailer, C.A., Hu, H., Trieb, M., Kaufmann, W.A., Schwarzer, C., Storm, J.F. & Knaus, H.G.: Apamin-sensitive small conductance Ca2+-activated K+ channels in rat brain: regional differences in distribution and functional expression; J. Neurosci. 22, 9698-9707 (2002)

[PubMed]

58. Pragl, B., Koschak, A., Trieb, M., Obermair, G., Kaufmann, W.A., Gerster, U., Blanc, E., Hahn, C., Prinz, H., Darbon, H., Gruber, H.J. and Knaus, H.G.: Synthesis, characterization and application of Cy-dye- and Alexa-dye-labeled hongotoxin1 analogues - first high-affinity probes for voltage-gated K+ channels. Bioconjugate Chem. 13, 416-425 (2002)

[PubMed]

iv. Synaptic proteins in Alzheimer's disease. Marksteiner J., Kaufmann, W.A. & Humpel, C.: J. Mol. Neurosci. 18., 53-63.

[PubMed]

iii. Reduction of chromogranin-like immunoreactivity in distinct subregions of the hippocampus from individuals with schizophrenia. Nowakowski, C., Kaufmann, W.A., Adlassnig, C., Mayer H., Salimi, K., Jellinger, K.A. & Marksteiner, J.: Schizophr.Res. 58, 43-53.

[PubMed]


2001
57. Hu, H., Shao, L.-R., Chavoshy, S., Gu, N., Trieb, M., Behrens, R., Laake, P., Pongs, O., Knaus, H.G., Ottersen, O.P. & Storm, J.F.: Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J. Neurosci. 21, 9585-9597 (2001)

[PubMed]

56. Klocker, N., Oliver, D., Ruppersberg, J.P., Knaus, H.G. & Fakler, B.: Developmental expresion of the small-conductance Ca2+-activated potassium channel SK2 in the rat retina; Mol. Cell. Neurosci. 17, 514-520 (2001)

[PubMed]

55. Michelakis, E.D., Weir, E.K., Waite, R.E., Puttagunta, L., Bateson, J., Knaus, H.G. & Archer, S.L.: Potassium channels regulate tone in rat pulmonary veins. Am. J. Physiol. (Heart Circ. Physiol) 280, L1138-L1147 (2001)

[PubMed]

ii. Apoptosis signals in sporadic in amyotrophic lateral sclerosis: an immunocytochemical study. Embacher, N., Kaufmann, W.A., Beer, R., Mayer, H., Jellinger K.A., Poewe, W. & Ransmayr G. Acta Neuropathol. 102, 426-434.

[PubMed]


2000
54. Bond, C.T., Sprengel, R., Bissonette, J.M., Kaufmann, W.A., Pribnow, D., Neelands, T., Storck, T., Baetscher, M., Jerecic, J., Maylie, J., Knaus, H.G., Seeburg, P.H., & Adelman, J.P.: Respiration and parturition affected by conditional overexpression of the small conductance Ca2+-activated K+ channel subunit, SK3. Science 289, 1942-1946 (2000)

[PubMed]

53. Eller, P., Berjukov, S., Wanner, S.G., Huber, I., Hering, S., Knaus, H.G., Todt, G., Kimball, S.D. & Striessnig, J.: High affinity interaction of mibefradil with voltage-gated calcium and sodium channels. Brit. J. Pharmacol. 130, 669-677 (2000)

[PubMed]

52. Legros, C., Pollmann, V., Knaus, H.G., Farrell, A.M., Darbon, H., Bougis, P.E., Martin-Eauclaire, M.-F., and Pongs, O.: Generating a high-affinity scorpion-toxin receptor in KcsA-Kv1.3 chirmeric potassium channels. J. Biol. Chem. 275, 16918-16924 (2000)

[PubMed]

51. Gruber, H.J., Hahn, C.D., Kada, G., Riener, C.K., Harms, G.S., Ahrer, W., Dax, T.G., Knaus, H.G.: Anomalous fluorescence enhancement of Cy3 and Cy3.5 versus anomalous fluorescence loss of Cy5 and Cy7 upon covalent linking to IgG and noncovalent binding to avidin. Bioconjugate Chem. 11, 696-704 (2000)

[PubMed]

50. Gruber, H.J., Kada, G., Pragl, B., Riener, C., Hahn, C.D., Harms, G.S., Ahrer, W., Dax, T.G., Hohenthanner, K., and Knaus, H.-G.: Preparation of thiol-reactive Cy5 derivatives from commercial Cy5 succinimidyl ester. Bioconjugate Chem. 11, 161-166 (2000)

[PubMed]


1999
49. Garcia, M.L., Hanner, M., Knaus, H.G., Slaughter, R.S. & Kaczorowski, G.J.: Scorpion toxins as tools for studying potassium channels; Method Enzymol. 294, 624-639 (1999)

[PubMed]

48. Garcia, M.L., Hanner, M., Knaus, H.G., Slaughter, R.S. & Kaczorowski, G.J.: Purification and functional reconstitution of high-conductance calcium-activated potassium channel from smooth muscle; Method Enzymol. 294, 274-287 (1999)

[PubMed]

47. Wanner, S.G., Glossmann, H., Knaus, H.G., Baker, R., Parsons, W., Rupprecht, K., Brochu, R., Cohen, C.J., Schmalhofer, W.A., Smith, M.M., Warren, W., Garcia, M.L. & Kaczorowski, G.J.: WIN 17317-3, a high-affinity probe for voltage-gated Na+ channels; Biochemistry 38, 11137-11146 (1999)

[PubMed]

46. Grunnet, M., Knaus, H.G., Solander, C. & Klaerke, D.: Quantification and distribution of Ca2+-activated K+ channels in rabbit distal colon. Am. J. Physiol. (Gastr) 277, G22-G30 (1999)

[PubMed]

45. Wanner, S.G., Koch, R.O., Koschak, A., Trieb, A., Garcia, M.L., Kaczorowski, G.J. & Knaus, H.G.: High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition; Biochemistry 38, 5392-5400 (1999)

[PubMed]


1998
i. Roeper, J., Sewing, S., Zhang, Y., Sommer, T., Wanner, S.G. & Pongs, O.: NIP domain prevents N-type inactivation in voltage-gated potassium channels; Nature 391, 390-393 (1998)

[PubMed]

44. Hanner, M., Vianna-Jorge, R., Kamassah, A., Schmalhofer, W.A., Knaus, H.G., Kaczorowski, G.J. & Garcia, M.L.: The beta-subunit of the high-conductance Ca2+-activated K+ channel: Identification of residues involved in charybdotoxin binding; J. Biol. Chem. 273, 16289-16296 (1998)

[PubMed]

43. Tian, L., Knaus, H.G. & Shipston, M.J.: Glucocorticoid inhibition of BK channels: a role for serine / threonine protein phosphatase; J. Biol. Chem. 273, 13531-13536 (1998)

[PubMed]

42. Liu, Y.P., Hudetz, A.G., Knaus, H.G. & Rusch, N.J.: Increased expression of Ca2+-activated K+ channels in the cerebral microcirculation of genetically hypertensive rats. Evidence for their protection against cerebral vasospasm; Circ. Res. 81, 729-737 (1998)

[PubMed]

41. Saria, A., Seidl, C.V., Koch, R.O., Telser, S., Wanner, S.G., Humpel, C., Garcia, M.L. & Knaus, H.G.: Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels; Eur. J. Pharmacol. 343, 193-200 (1998)

[PubMed]

40. Koschak, A., Bugianesi, R.M., Mitterdorfer, J., Kaczorowski, G.J., Garcia, M.L. & Knaus, H.G.: Subunit composition of brain voltage-gated potassium channels determined by hongotoxin1, a novel peptide derived from Centruroides limbatus venom; J. Biol. Chem. 273, 2639-2644 (1998)

[PubMed]


1997
39. Garcia, M.L., Hanner, M., Knaus, H.G., Koch, R.O., Schmalhofer, W.A., Slaughter, R.S. & Kaczorowski, G.J.: Pharmacology of potassium channels; Adv. Pharmacol. 39, 425-471 (1997)

[PubMed]

38. Liu, Y.P., Knaus, H.G. & Rusch, N.J.: Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats. Hypertension 30, 1403-1409 (1997)

[PubMed]

37. Tanaka, T., Meera, P., Song, M., Knaus, H.G. & Toro, L.: Molecular constituents of maxiKCa channels in human coronary smooth muscle: predominant alpha and beta complexes. J. Physiol. 502, 545-557 (1997)

[PubMed]

36. Hanner, M., Schmalhofer, W.A., Munujos, P., Knaus, H.G., Kaczorowski, G.J. & Garcia, M.L.: The beta-subunit of the high-conductance Ca2+-activated K+ channel contributes to the high affinity receptor for charybdotoxin; Proc. Natl. Acad. Sci. U.S.A. 94, 2853-2858 (1997)

[PubMed]

35. Helms, L., Felix, J.P., Bugianesi, R.M., Garcia, M.L., Stevens, S., Leonard, R.J., Knaus H.G., Koch, R.O., Wanner, S.G., Kaczorowski G.J., & Slaughter, R.S.: Margatoxin binds to a homomultimer of Kv1.3 channels in Jurkat cells; Comparison with Kv1.3 expressed in CHO cells; Biochemistry 36, 3737-3744 (1997)

[PubMed]

34. Koch, R.O., Wanner, S.G., Koschak, A., Hanner, M., Schwarzer, C., Kaczorowski, G.J., Slaugther, R.S., Garcia, M.L. & Knaus, H.G.: Complex subunit assembly of neuronal voltage-gated K+ channels: basis for high-affinity toxin interactions and pharmacology; J. Biol. Chem. 272, 27577-27581 (1997)

[PubMed]

33. Koschak, A., Koch, R.O., Liu, J., Kaczorowski, G.J., Reinhart, P.H., Garcia, M.L. & Knaus, H.G.: [125]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels; Biochemistry 36, 1943-1952 (1997)

[PubMed]


1996
32. Kaczorowski, G.J., Knaus, H.G., Leonard, R., McManus, O.B. & Garcia, M.L.: High conductance calcium-activated potassium channels; structure, pharmacology, and function; J. Bioenerg. Biomembr. 28, 255-267 (1996)

[PubMed]

31. Hanner, M., Moebius, F.F., Flandorfer, A., Knaus, H.G., Striessnig, J., Kempner, E., & Glossmann, H.: Purification, molecular cloning and expression of the mammalian sigma1- binding site; Proc. Natl. Acad. Sci. U.S.A. 93, 8072-8077 (1996)

[PubMed]

30. Knaus, H.G., Schwarzer, C., Koch, R.O., Eberhart, A., Kaczorowski, G.J., Glossmann, H., Wunder, F., Pongs, O., Garcia, M.L. & Sperk, G.: Distribution of high-conductance Ca2+-activated K+ channels in rat brain: targeting to axons and nerve terminals; J. Neurosci. 16, 955-963 (1996)

[PubMed]


1995
29. Garcia, M.L., Knaus, H.G., Munujos, P., Slaughter, R.S., & Kaczorowski, G.J.: Charybdotoxin and its effects on potassium channels; Am. J. Physiol. 269, C1-C10 (1995)

[PubMed]

28. Giangiacomo, K.M., Garcia-Calvo, M., Knaus, H.G., Mullmann, T.J., Garcia, M.L. & McManus, O.B.: Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle; Biochemistry 34, 15849-15862 (1995)

[PubMed]

27. Munujos, P., Knaus, H.G., Kaczorowski, G.J. & Garcia, M.L.: Crosslinking of ChTX to high-conductance Ca2+-activated K+ channels: Identification of the covalently modified toxin residue; Biochemistry 34, 10771-10776 (1995)

[PubMed]

26. Knaus, H.G., Koch, R.O., Eberhart, A., Kaczorowski, G.J., Garcia, M.L. & Slaughter, R.L.: [125I]Margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mamalian brain; Biochemistry 34, 13627-13634 (1995)

[PubMed]

25. Knaus, H.G., Eberhart, A., Koch, R.O., P. Munujos, P., Schmalhofer, W.A., Warmke, J.W., Kaczorowski, G.J., & Garcia, M.L.: Characterization of the alpha-subunit of the high-conductance Ca2+-activated K+ channel from tracheal smooth muscle; J. Biol. Chem. 270, 22434-22439 (1995)

[PubMed]


1994
24. Moebius, F.F., Hanner, M., Knaus, H.G., Striessnig, J. & Glossmann, H.: Purification and N-terminal sequencing of the high-affinity phenylalkylamine calcium antagonist binding protein from guinea-pig liver endoplasmic reticulum; J. Biol. Chem. 269, 29314-29320 (1994)

[PubMed]

23. Garcia-Calvo, M., Knaus, H.G., Kaczorowski, G.J., Garcia, M.L. & Kempner, E.: Functional unit size of the charybdotoxin receptor in smooth muscle; Proc. Natl. Acad. Sci. U.S.A. 91, 4718-4722 (1994)

[PubMed]

22. Garcia-Calvo, M., Knaus, H.G., McManus, O.B., Giangiacomo, K.M., Kaczorowski, G.J. & Garcia, M.L.: Purification and reconstitution of the high-conductance calcium-activated potassium channel from tracheal smooth muscle; J. Biol. Chem. 269, 676-682 (1994)

[PubMed]

21. Knaus, H.G., Eberhart, A., Glossmann, H., Munujos, P., Kaczorowski, G.J. & Garcia, M.L.: Pharmacology and structure of high-conductance calcium-activated potassium channels; Cell. Signal. 6, 861-870 (1994)

[PubMed]

20. Knaus, H.G., Eberhart, A. Kaczorowski, G.J. & Garcia, M.L.: Covalent attachment of charybdotoxin to the beta-subunit of the high-conductance Ca2+-activated K+ channel: Identification of the site of incorporation and implications for channel topology; J. Biol. Chem. 269, 23336-23341 (1994)

[PubMed]

19. Knaus, H.G., Folander, K., Garcia-Calvo, M., Garcia, M.L., Kaczorowski, G.J., Smith, M.M. & Swanson, R.: Primary sequence and immunological characterization of the beta-subunit of the high-conductance Ca2+-activated K+ channel from smooth muscle; J. Biol. Chem. 269, 17274-17278 (1994)

[PubMed]

18. Knaus, H.G., McManus, O.B., Lee, S.H., Schmalhofer, W., Garcia-Calvo, M., Helms, L.M.H., Sanchez, M., Giangiacomo, Garcia, M.L., Reuben, J.P., Smith III, A.B. & Kaczorowski, G.J.: Tremorgenic indole alkaloids potently inhibit smooth muscle high- Ca2+-activated K+ channels; Biochemistry 33, 5819-5828 (1994)

[PubMed]

17. Knaus, H.G., Garcia-Calvo, M., Kaczorowski, G.J. & Garcia, M.L.: Subunit composition of the high-conductance Ca2+-activated K+ channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels; J. Biol. Chem. 269, 3921-3924 (1994)

[PubMed]


1993
16. Lakitsch, M., Knaus, H.G., Topar, G., Romanin, C., Boer, R., Flockerzi, D., Striessnig, J., Schindler, H.G., Hoeltje, H.D. & Glossmann, H.: Heterogeneity of L-type calcium channel alpha1 subunits: stereoselective discrimination of different populations by the novel 1,4-dihydropyridine B 874-67; Mol. Pharmacol. 43, 293-301 (1993)

[PubMed]


1992
15. Knaus, H.G., Striessnig, J., Hering, S., Marrer, S., Schwenner, E., Hoeltje, H.D. & Glossmann, H.: [35S]Sadopine, a novel high affinity, high specific activity L-type Ca2+-channel probe: characterization of two equipotent diastereomers with opposite allosteric properties; Mol. Pharmacol. 41, 298-307 (1992)

[PubMed]

14. Knaus, H.G., Moshammer, T., Kang, H.C., Haugland, R.P. & Glossmann, H.: A unique fluorescent phenylalkylamine probe for L-type Ca2+-channels; J. Biol. Chem. 267, 2179-2189 (1992)

[PubMed]

13. Knaus, H.G., Moshammer, T., Friedrich, K., Kang, H.C., Haugland, R.P. & Glossmann, H.: In vivo labeling of L-type Ca2+ -channels by fluorescent dihydropyridines: evidence for a functional, extracellular heparin binding site; Proc. Natl. Acad. Sci. U.S.A. 89, 3586-3590 (1992)

[PubMed]


1991
12. Knaus, G.A. Knaus, H.G. & Saria A.: Complex allosteric interaction of heparin with neurokinin-1 receptors; Eur. J. Pharmacol. 207, 267-270 (1991)

[PubMed]

11. Staudinger, R., Knaus, H.G. & Glossmann, H.: Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type calcium channel; J. Biol. Chem. 266, 10787-10795 (1991)

[PubMed]

10. Grabner, M., Friedrich, K., Knaus, H.G., Striessnig, J., Scheffauer, F., Staudinger, R., Koch, E.J., Schwartz, A. & Glossmann H.: Calcium channels from Cyprinus carpio skeletal muscle; Proc. Natl. Acad. Sci. U.S.A. 88, 727-731 (1991)

[PubMed]


1990
09. Kieselbach, G.F., Ragaut, R., Knaus, H.G., Koenig, P., & Wiedermann, C.J.: Neurokinin receptors in the human eye: characterization and autoradiographic distribution; Peptides 11, 655-659 (1990)

[PubMed]

08. Humpel C., Knaus, G.A., Auer, B., Knaus, H.G., Haring C., Theodorsson, E., & Saria, A.: Effects of haloperidol and clozapine on preprotachykinin-A messenger RNA, tachykinin tissue levels, tachykinin release and [125I]Bolton-Hunter substance P binding in the nigro-striatal system; Synapse 6, 1-9 (1990)

[PubMed]

07. Knaus, H.G., Scheffauer, F., Romanin, C., Schindler, H.G. & Glossmann, H.: Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels; J. Biol. Chem. 265, 11156-11166 (1990)

[PubMed]


1989
06. Grassegger, A., Striessnig, J., Weiler, M., Knaus, H.G. & Glossmann, H.: [3H]HOE166 defines a novel calcium antagonist drug receptor - distinct from the 1,4 dihydropyridine binding domain; Naunyn Schmiedebergs Arch. Pharmacol. 340, 752-759 (1989)

[PubMed]


1988
05. Striessnig, J., Knaus, H.G. & Glossmann, H.: Photoaffinity labelling of the calcium channel-associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea-pig hippocampus; Biochem. J. 253, 39-47 (1988)

[PubMed]

04. Striessnig, J., Meusburger, E., Grabner, M., Knaus, H.G., Glossmann, H., Kaiser, J., Schoelkens, B., Becker, R., Linz, W. & Henning, R.: Evidence for a distinct Ca2+ antagonist receptor for the novel Ca2+-channel blocker HOE166; Naunyn Schmiedebergs Arch. Pharmacol. 337, 331-340 (1988)

[PubMed]


1987
03. Vaghy, P.L., Striessnig, J., Miwa, K., Knaus, H.G., Itagaki, K., McKenna, E., Glossmann, H. & Schwartz, A.: Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations; J. Biol. Chem. 262, 14337-14342 (1987)

[PubMed]

02. Knaus H.G., Striessnig J., Koza A. & Glossmann H.: Neurotoxic aminoglycoside antibiotics are potent inhibitors of [125I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes; Naunyn Schmiedebergs Arch. Pharmacol. 336, 583-586 (1987)

[PubMed]

01. Striessnig, J., Knaus, H.G., Grabner, M., Moosburger K., Seitz, E., Lietz, H. & Glossmann, H.: Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel; FEBS Lett. 212, 247-253 (1987)

[PubMed]


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