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DNA translating ribosomes

Nina Clementi (Postdoctoral Fellow)

The ribosome is in charge of providing fast and accurate protein synthesis in every living cell. Therefore it is inevitable that the genetic information is transcribed into RNA, which then can be used as template for the ribosome. However, experiments form the 1960s indicate that under certain conditions also DNA can be used as template for protein synthesis. We in the process of establishing an in vitro selection approach, that allows us to generate mutant ribosomes capable of translating DNA

Figure taken from: Francis Crick, Central Dogma of Molecular Biology. 1970 Nature, 227, 561-563;