Publication highlights

Loss of the orphan nuclear receptor NR2F6 enhances CD8(+) T-cell memory via IFN-gamma. Jakic B, Olson WJ, Siegmund K, Klepsch V, Kimpel J, Labi V, Zehn D, Baier G, Hermann-Kleiter N. Cell Death Dis. 2021 Feb 15;12(2):187. doi: 10.1038/s41419-021-03470-9.

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.Olson WJ, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, Baier G, Hermann-Kleiter N. Cell Rep. 2019 Sep 10;28(11):2878-2891.e5.



Loss of the orphan nuclear receptor NR2F6 enhances CD8(+) T-cell memory via IFN-gamma. Jakic B, Olson WJ, Siegmund K, Klepsch V, Kimpel J, Labi V, Zehn D, Baier G, Hermann-Kleiter N. Cell Death Dis. 2021 Feb 15;12(2):187. doi: 10.1038/s41419-021-03470-9.

Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function. Bellmann L, Zelle-Rieser C, Milne P, Resteu A, Tripp CH, Hermann-Kleiter N, Zaderer V, Wilflingseder D, Hörtnagl P, Theochari M, Schulze J, Rentzsch M, Del Frari B, Collin M, Rademacher C, Romani N, Stoitzner P. J Invest Dermatol. 2021 Jan;141(1):84-94.e6. doi: 10.1016/j.jid.2020.05.098.

Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function. Tymoszuk P, Nairz M, Brigo N, Petzer V, Heeke S, Kircher B, Hermann-Kleiter N, Klepsch V, Theurl I, Weiss G, Pfeifhofer-Obermair C. Front Oncol. 2020 Dec 4;10:584477. doi: 10.3389/fonc.2020.584477

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter. Coassin S, Hermann-Kleiter N, Haun M, Wahl S, Wilson R, Paulweber B, Kunze S, Meitinger T, Strauch K, Peters A, Waldenberger M, Kronenberg F, Lamina C. PLoS One. 2020 Apr 28;15(4):e0232073.

Regulation of the germinal center response by nuclear receptors and implications for autoimmune diseases. Olson WJ, Jakic B, Hermann-Kleiter N. FEBS J. 2020 Apr 4. doi: 10.1111/febs.15312. 

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy. Klepsch V, Pommermayr M, Humer D, Brigo N, Hermann-Kleiter N, Baier G. Cell Commun Signal. 2020 Jan 14;18(1):8.

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.Olson WJ, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, Baier G, Hermann-Kleiter N. Cell Rep. 2019 Sep 10;28(11):2878-2891.e5.

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD. Klepsch V, Moschen AR, Tilg H, Baier G, Hermann-Kleiter N. Front Immunol. 2019 May 14;10:1070.

CHK1 dosage in germinal center B cells controls humoral immunity. Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N, Villunger A, Labi V. Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5

Fcμ receptor as a Costimulatory Molecule for T Cells. Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein B. Cell Rep. 2019 Mar 5;26(10):2681-2691.e5. 

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b. Peer S, Cappellano G, Hermann-Kleiter N, Albrecht-Schgoer K, Hinterleitner R, Baier G, Gruber T. Front Immunol. 2018 Oct 8;9:2311.

Nuclear Receptor NR2F6 Inhibition Potentiates Responses to PD-L1/PD-1 Cancer Immune Checkpoint Blockade. Klepsch V., Hermann-Kleiter N., Offermann A., Efremova M., Rieder D., Krogsdam A., Perner S., Tzankov A., Trajanoski Z., Wolf D. and Baier G.: Nat Commun. 2018 Apr 18;9(1): 

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution. Efremova M, Rieder D, Klepsch V, Charoentong P, Finotello F, Hackl H, Hermann-Kleiter N, Löwer M, Baier G, Krogsdam A, Trajanoski Z. Nat Commun. 2018 Jan 2;9(1):32.

NAD metabolism fuels human and mouse intestinal inflammation. R. R Gerner, V. Klepsch, S. Macheiner, K. Arnhard, T. E Adolph, C. Grander, V. Wieser, A. Pfister, P. Moser, N. Hermann-Kleiter, G. Baier, H. Oberacher, H.Tilg, A. R Moschen. Gut. 2018 Oct;67(10):1813-1823.

Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis. Klepsch V, Gerner RR, Klepsch S, Olson WJ, Tilg H, Moschen AR, Baier G, Hermann-Kleiter N. Gut. 2018 Aug;67(8):1434-1444.

Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells. Siegmund K, Thuille N, Wachowicz K, Hermann-Kleiter N, Baier G. PLoS One. 2017 May 22;12(5):e0175463. doi: 10.1371/journal.pone.0175463. eCollection 2017.

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A. Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G. J Biol Chem. 2016 Oct 14;291(42):22086-22092. 

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice. Pfeifhofer-Obermair C, Albrecht-Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G. Cell Commun Signal. 2016 Jul 28;14(1):14. doi: 10.1186/s12964-016-0137-y.

Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy. Klepsch V, Hermann-Kleiter N, Baier G. Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007.

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance. Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G. Cell Rep. 2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035.

Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions. Hermann-Kleiter N, Baier G. Cell Commun Signal. 2014 Jun 12;12:38. doi: 10.1186/1478-811X-12-38. Review.

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells. Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G. PLoS One. 2014 May 2;9(5):e96401. doi:10.1371/journal.pone.0096401. eCollection 2014.

LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells. Thauerer B, Voegele P, Hermann-Kleiter N, Thuille N, de Araujo ME, Offterdinger M, Baier G, Huber LA, Baier-Bitterlich G.PLoS One. 2014 Apr 21;9(4):e95863. doi: 10.1371/journal.pone.0095863. eCollection 2014. 

Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells. Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A, Pfeifhofer-Obermair C, Baier G.J Mol Cell Biol. 2013 Dec;5(6):358-68. doi: 10.1093/jmcb/mjt017. 

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, Leitges M, Thome M, Massoumi R, Baier G.PLoS One. 2013;8(1):e53709. doi: 10.1371/journal.pone.0053709.

The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses. Meisel M, Hermann-Kleiter N, Hinterleitner R, Gruber T, Wachowicz K, Pfeifhofer-Obermair C, Fresser F, Leitges M, Soldani C, Viola A, Kaminski S, Baier G. Immunity. 2013 Jan 24;38(1):41-52. doi: 10.1016/j.immuni.2012.09.021. 

Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage. Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A. Cell Death Differ. 2013 Apr;20(4):546-57. doi: 10.1038/cdd.2012.152.

Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter. Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, Müller M, Roth L, Katopodis A, Baier G. J Autoimmun. 2012 Dec;39(4):428-40. doi: 10.1016/j.jaut.2012.07.007. 

Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G. J Autoimmun. 2011 Nov;37(3):198-208. doi: 10.1016/j.jaut.2011.05.018.

NFAT pulls the strings during CD4+ T helper cell effector functions. Hermann-Kleiter N, Baier G. Blood. 2010 Apr 15;115(15):2989-97. doi: 10.1182/blood-2009-10-233585. Review.

PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation. Thuille N, Lutz-Nicoladoni C, Letschka T, Hermann-Kleiter N, Heit I, Baier G. Immunol Lett. 2009 Sep 22;126(1-2):54-9. doi: 10.1016/j.imlet.2009.07.014.

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G. Sci Signal. 2009 Jun 23;2(76):ra30. doi: 10.1126/scisignal.2000046.

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation. Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. 

Lasp1 misexpression influences chondrocyte differentiation in the vertebral column. Hermann-Kleiter N, Ghaffari-Tabrizi N, Blumer MJ, Schwarzer C, Mazur MA, Artner I. Int J Dev Biol. 2009;53(7):983-91. doi: 10.1387/ijdb.072435nh.

PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein Hildesheim B, Wagner J, Leitges M, Baier G. Mol Immunol. 2009 Jun;46(10):2071-9. doi: 10.1016/j.molimm.2009.02.030. Epub 2009 Apr 7.

PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Letschka T, Kollmann V, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Obermair GJ, Fresser F, Leitges M, Hermann-Kleiter N, Kaminski S, Baier G. Blood. 2008 Dec 1;112(12):4617-27. doi: 10.1182/blood-2007-11-121111. Epub 2008 Sep 16.

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G. Immunity. 2008 Aug 15;29(2):205-16. doi: 10.1016/j.immuni.2008.06.008.

Defective IgG2a/2b class switching in PKC alpha-/- mice. Pfeifhofer C, Gruber T, Letschka T, Thuille N, Lutz-Nicoladoni C, Hermann-Kleiter N, Braun U, Leitges M, Baier G. J Immunol. 2006 May 15;176(10):6004-11.

PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes. Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G. Blood. 2006 Jun 15;107(12):4841-8. Epub 2006 Mar 2.

Protein kinase Cepsilon is dispensable for TCR/CD3-signaling. Gruber T, Thuille N, Hermann-Kleiter N, Leitges M, Baier G. Mol Immunol. 2005 Feb;42(3):305-10.

Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11. Kleiter N, Artner I, Gmachl N, Ghaffari-Tabrizi N, Kratochwil K. Cytogenet Genome Res. 2002;97(1-2):100-5.2.

Genomic organization and chromosome location of the murine Rpl23 gene. Kleiter N, Artner I, Copeland NG, Gilbert DJ, Jenkins NA, Kratochwil K. Cytogenet Cell Genet. 2000;90(3-4):227-30.

Microvascularization of the pineal gland in the freshwater turtle, Pseudemys scripta elegans (Reptilia): a scanning electron microscopic study of vascular corrosion casts. Kleiter N, Lametschwandtner A. J Pineal Res. 1995 Sep;19(2):93-102.

Microvascularization of the cerebellum in the turtle, Pseudemys scripta elegans (Reptilia). A scanning electron microscope study of microvascular corrosion casts, including stereological measurements. Kleiter N, Lametschwandtner A. Anat Embryol (Berl). 1995 Feb;191(2):145-53

Kleiter Lab