Prof. Klaus Scheffzek

Institute of Biological Chemistry, Biocentre, Medical University of Innsbruck

Defects in signalling pathways are often associated with the occurence of severe diseases, e.g. cancer. We are interested in understanding the mechanisms of pathogenesis associated with cancer-related diseases. Currently a major focus is neurofibromatosis type 1 (NF1), a genetic disease with an incidence of 1 in 3500 newborns. NF1 patients have an increased tumor risk, may show a variety of developmental defects and frequently have learning disabilities.

The NF1 gene encodes a huge protein (20 times larger than the oxygen carrier protein myoglobin), termed neurofibromin, and when mutated is responsible for the disease pathology. Our goal is to define the functional spectrum of neurofibromin by following a structural proteomics approach.


Research Interests
- Small G-proteins and their regulation
- Protein kinases
- Chromatin remodeling/transcription
- Plant science
- Complex machineries

Scientific Curriculum

2011 Univ.-Prof. Chair Biological Chemistry/Structural Biology (Medical University of Innsbruck)
2001-2010 Group leader at EMBL (Structural Biology/Developmental Biology)
May 2009 'Außerplanmäßiger Professor’ (University Heidelberg)
SS 2009 Lehrstuhlvertretung, (lecturing/examination) in Biochemistry (Univ/FZ  Karlsruhe, A. Ulrich)
2004 Habilitation in Biochemistry/Biophysics
1999-2001 Staff Scientist in the Structural and Computational Biology Programm EMBL
1998-1999 Group leader, MPI f. Molecular Physiology (Dpt. Structural Biology), Dortmund
1995-1998 Post doctoral work, MPI f. Molecular Physiology (Dpt. Structural Biology, A. Wittinghofer), Dortmund
1995 Dr. rer. nat in Biology (’summa cum laude’)
1992-1995 Doctoral thesis, MPI f. Medical Research (Dpt. Biophysics. K.C. Holmes, A. Wittinghofer), Heidelberg
1992 Diploma in Biology (’sehr gut’)
1986-1992 Study of Biology, Ruprecht-Karls-Universität Heidelberg
1984 Diploma in Physics (’sehr gut’)
1977-1984 Study of Physics, Ruprecht-Karls-Universität Heidelberg












Publications (selected)

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. de Araujo MEG, Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K. Science. 2017, 358:377-381.

The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K. Proc Natl Acad Sci U S A. 2016, 113:7497-502.



Prof. Klaus Scheffzek, PhD
Innrain 80-82, CCB-Building,
A-6020 Innsbruck
Tel:    +43 512 9003 70300
Fax:    +43 512 9003 73110