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Disease specific engineering of designer receptor gene therapies

 

The main research focus of the laboratory aims for preclinical development and optimisation of gene therapies for neurological disorders, like epilepsy, Parkinson’s disease, neuropathic pain, or multiple sclerosis. Refractory epilepsy and Parkinson’s disease are amongst the most common neurological disorders, with more than 21 million and 6 million patients worldwide, respectively. Despite huge efforts to investigate and develop novel treatment strategies, both diseases are still difficult to treat. Multiple gene therapeutic options targeting Parkinson’s disease or refractory epilepsy have already been explored. However, all of them are limited by specific disadvantages, which we aim to overcome by disease specific engineering of designer receptors. In recent years, we developed a biochemical autoregulatory gene therapeutic system targeting refractory epilepsy. This is only activated if the excitatory neurotransmitter glutamate rises pathologically and suppresses emerging seizures. In addition, we identified a novel licensed drug activating the currently available designer receptor exclusively activated by designer drugs (DREADD). This drug comprises a superior side effect profile, facilitating the translation of this technology. Together these major achievements highlight that custom engineering of disease specific designer receptors is indeed feasible and will help to develop technologies with maximised therapy efficacy and minimal risk of side effects. Although, we were already able to advance/develop gene therapeutic strategies for the treatment of refractory epilepsy, we consider the currently available options not ideal. We will therefore further develop new and enhance existing technologies. In addition, we will expand the on-demand engineering of designer receptor gene therapies to other neurological diseases, like Parkinson’s disease.

 

Curriculum Vitae

 

Research projects and third-party funding

 

Publications

 

Collaboration Partners

 

 

Forschung

Kontakt:

Iris Markt
Tel.: +43 (0)512/9003-71201
E-Mail: iris.markt@i-med.ac.at

Fax: +43 (0)512/9003-73200
E-Mail: pharmakologie@i-med.ac.at

Peter-Mayr-Straße 1a
A-6020 Innbruck

Sie finden uns hier.

 

research funded by:

FWF

Kontakt:

Iris Markt
Tel.: +43 (0)512/9003-71201
E-Mail: iris.markt@i-med.ac.at

Fax: +43 (0)512/9003-73200
E-Mail: pharmakologie@i-med.ac.at

Peter-Mayr-Straße 1a
A-6020 Innbruck

Sie finden uns hier.

 

research funded by:

FWF