Isidor Happacher, MSc.
EMail: isidor.happacher[at]i-med.ac.at
Short curriculum
| 2023-... |
Start of the PhD project entitled “Fungal siderophore utilization specificity” in the “Infection, Immunity & Transplantation (IIT)” programme. In the laboratory of Prof. Hubertus Haas, Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, Austria |
| 2022-2023 |
Research Assistant in the laboratory of Prof. Hubertus Haas, Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, Austria |
| 2020-2022 |
Master’s in microbiology, University of Innsbruck, Austria |
| 2016-2020 |
Bachelor’s in biology, University of Innsbruck, Austria |
Research fields
molecular mycology
fungal iron homeostasis
siderophore metabolism
Publications
- Happacher I, Aguiar M, Alilou M, Abt B, Baltussen TJH, Decristoforo C, Melchers WJG, Haas H. The Siderophore Ferricrocin Mediates Iron Acquisition in Aspergillus fumigatus. Microbiol Spectr. 2023 Jun 15;11(3):e0049623. doi: 10.1128/spectrum.00496-23. Epub 2023 May 18. PMID: 37199664; PMCID: PMC10269809.
- Happacher I, Aguiar M, Yap A, Decristoforo C, Haas H. Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications. Essays Biochem. 2023 Sep 13;67(5):829-842. doi: 10.1042/EBC20220252. PMID: 37313590; PMCID: PMC10500206.
- Happacher I, Oberegger S, Abt B, Yap A, Caballero P, Aguiar M, Pervaiz J, Gariglio G, Misslinger M, Decristoforo C, Haas H. FpnA, the Aspergillus fumigatus homolog of human ferroportin, mediates resistance to nickel, cobalt and gallium but does not function in iron homeostasis. Commun Biol. 2025 Mar 8;8(1):399. doi: 10.1038/s42003-025-07799-1. PMID: 40057608; PMCID: PMC11890741.
- Zhu C, Liu Q, Chen Y, Tian F, Kong D, Happacher I, Haas H, Zhang Y, Luo Z. The siderophore-iron transporter BbMirB is required for the fungal pathogen Beauveria bassiana to repress insect immunity and promote proliferation during colonization of hemocoel. mBio. 2025 Oct 8;16(10):e0198125. doi: 10.1128/mbio.01981-25. Epub 2025 Aug 25. PMID: 40852985; PMCID: PMC12506104.
- Oberegger S, Misslinger M, Happacher I, Haas H. Functional transitions of the Aspergillus fumigatus iron regulator HapX are governed by conserved domains cooperatively binding [2Fe-2S] clusters. Nucleic Acids Res. 2025 Aug 27;53(16):gkaf796. doi: 10.1093/nar/gkaf796. PMID: 40867055; PMCID: PMC12390756.
- Alilou M, Liu Y, Steixner M, Happacher I, Abt SB, Fürnkranz U, Gsaller F, Peintner U, Haas H. Bioactive specialized metabolites of Trochila sp., an endophytic fungus of Lilium carniolicum. Phytochemistry. 2025 Sep 24;242:114684. doi: 10.1016/j.phytochem.2025.114684. Epub ahead of print. PMID: 41005518.
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