Gabriele Baier-Bitterlich, Ph.D.   

 

Publications

 

1. G.Bitterlich and E.Gnaiger,1984. Phytoplanktivorous or omnivorous fish? Digestibility of Zooplankton by silvercarp, Hypophthalmichthys molitrix (Val.). Aquaculture 40, 261-263.

 

2. E. Gnaiger and G. Bitterlich,1984. Proximate biochemical composition and caloric content calculated from elemental CHN analysis: a stoichiometric concept. Oecologia 62, 289-298.

 

3. G.Bitterlich,1985. The nutrition of stomachless phytoplanktivorous fish in comparison with Tilapia. Hydrobiologia 121, 173-179.

 

4. G.Bitterlich,1985. Digestive enzyme pattern of two stomachless filterfeeders, silvercarp (Hypophthalmichthys molitrix ) and bigheadcarp (Aristichthys nobilis). J.Fish Biology 27, 103-112.

 

5. G.Bitterlich,1985. Digestive processes in silvercarp (Hypophthalmichthys molitrix) studied in-vitro. Aquaculture 50, 123-131.

 

6. G.Bitterlich and E.Schaber,1986. Bacteria- food or food competitors of silvercarp Hypophthalmichthys molitrix)? Growth of aerobic and anaerobic bacteria in the gut fluid and tissues surrounding the alimentary tract and their influence on tryptic activity. J.Fish Biol.29, 605-612.

 

7. G.J.Dalla Via, U.Tappeiner, and G.Bitterlich,1987. Shore-level related morphological and physiological variations in the mussel Mytilus gallaprovincialis (Lamarck,1819) (Mollusca bivalvia) in the North Adriatic sea. Monitore Zool.Ital. (N.S.) 21, 293-305.

 

8. E.R.Werner, G.Bitterlich, D.Fuchs, A.Hausen, G.Reibnegger, G.Szabo, M.P.Dierich and H.Wachter,1987. Human macrophages degrade tryptophan upon induction by interferon-gamma. Life Sciences 41, 273-280.

 

9. G. Bitterlich, G. Szabo, E.R. Werner, C. Larcher, D. Fuchs, A. Hausen, G. Reibnegger, T.F. Schulz, J. Troppmair, H. Wachter, and M.P. Dierich,1988. Selective induction of mononuclear phagocytes to produce neopterin by interferons. Immunobiol.176, 228-235.

 

10. G. Bitterlich, C. Larcher, T.F. Schulz, B. Sˆlder, P. Hengster, B.L. Myones, J. Hofbauer, H. Wachter, and M.P. Dierich,1988. Effect of D-Penicillamine on the expression and propagation of the Human Immunodeficiency Virus by H9 T-Lymphoblastoid cells. Arzneimittelforsch./Drug Res. 39, 825-828.

 

11. B.M. Sˆlder, T.F.Schulz, P.Hengster, J.Loewer, C.Larcher, G.Bitterlich, R.Kurth, H. Wachter, and M.P.Dierich,1989. HIV and HIV-infected cells differentially activate the human complement system independant of antibody. Immunol. Lett. 22, 135-146.

 

12. E.C.Reisinger, W.Vogetseder, D.Berzow, D.Kˆfler, G.Bitterlich, H.A.Lehr, H.Wachter, and M.P.Dierich,1990. Complement- mediated enhancement of HIV-1 infection of the monoblastoid cell line U937. AIDS 4, 961-965.

 

13. G.Baier-Bitterlich, W.Schumacher, T.F.Schulz, H.Wachter, and M.P.Dierich,1993. Effects of D-Penicillamine on human cell lines. Arzneimittelforsch./ Drug Res. 3,395-398.

 

14. G.Baier, D.Telford, L.Giampa, K.M.Coggeshall, G.Baier-Bitterlich, N.Isakov, and A.Altman, 1993. Molecular cloning and characterization of PKCq, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J.Biol.Chem. 268, 4997-5004.

 

15. G.Baier-Bitterlich, W.Schumacher, E.Reisinger, B.Sˆlder, C.Larcher, A.Hausen, H.Wachter, and M.P.Dierich, 1993. Effects of Thiols and Disulfides on human T-Lymphoblastoid cells. Pharmacology comm. 3, 163-174.

 

16. G.Baier-Bitterlich, J.Rappaport, G.Baier, D.Looney, and F.Wong-Staal, 1994. Transcellular activation of the HTLV promoter by human hematopoietic cells. Oncogene 9, 319-322.

 

17. G.Baier, K.M.Coggeshall, G.Baier-Bitterlich, D.Telford, L.Giampa, and A.Altman, 1994. Construction and characterization of chimeric p56lck – and p59fyn – specific tRNA:ribozymes. Mol.Immunol. 31, 923-932.

 

18. C.Couture, G.Baier, C.Oetken, S.Williams, D.Telford, A.M.Cardine, G.Baier-Bitterlich,

S.Fischer, P.Burn, A.Altman, M.v.Willebrand, T.Pessa-Morikawa, and T.Mustelin, 1994. Activation of p56lck by phosphorylation at Tyr-192 in the SH2 domain. Mol.Cell.Biology 14, 5249-5258

 

19. E.Gulbins, K.M.Coggeshall, G.Baier, D.Telford, C.Langlet, G.Baier-Bitterlich, N.Bonnefoy-Berard, P.Burn, A.Wittinghofer, and A.Altman, 1994. Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides, 1994. Mol.Cell.Biology, 14, 4749-4758.

 

20. G. Baier, G.Baier-Bitterlich, C.Couture, D.Telford, L.Giampa, and A.Altman, 1994. An

efficient expression, purification and immunodetection system for recombinant gene

products, Bio/Techniques 17, 94-99.

 

21. R.Morgan, G.Bitterlich, J.Ragheb, F.Wong-Staal, R.C.Gallo, and F.Anderson, 1994. Further evaluation of sCD4 as an anti-HIV gene therapy: demonstration of protection of primary human peripheral blood lymphocytes from infection by HIV-1. AIDS Res.and Hu. Retro. 10, 1507-1515.

 

22. G.Baier, G.Baier-Bitterlich, N.Meller, K.M.Coggeshall, L.Giampa, D.Telford, N.

Isakov, and A.Altman,1994. Biochemical characterization of human protein kinase C q.

Eur.J.Biochem. 225, 195-203.

 

23. G.Baier-Bitterlich, G.Baier, E.Gulbins, K.M.Coggeshall, and A.Altman, 1995. The role of p56lck in CD4-mediated suppression of CD3-induced early signaling events in T

lymphocytes. Life Sciences 56, 1287-1297.

 

24. M.Erdel, G.Baier-Bitterlich, C.Duba, N.Isakov, A.Altman, G.Utermann, and G.Baier, 1995. Mapping of the human protein kinase C t gene locus to the short arm of chromosome 10 (10p15) by FISH. Genomics 25, 595-597.

 

25. E.Gulbins, R.Bissonette, A.Mahboubi, S.Martin, W.Nishioka, T.Brunner, G.Baier,

G.Baier- Bitterlich, C.Byrd, R.Kolesnick, A.Altman, and D.Green, 1995. Fas-induced apoptosis is mediated by a ceramide-initiated Ras signaling pathway.Immunity 2, 341- 351.

 

26. G.Werner-Felmayer, G.Baier-Bitterlich, D.Fuchs, A.Hausen, C.Murr, G.Reibnegger,

E.R.Werner, and H.Wachter, 1995. Detection of bacterial pyrogens by their effect on

interferon-g mediated formation of neopterin or nitrite in cultured monocyte cell lines.

Clin.Diag.Lab.Immunol. 2, 307-313.

 

27. G.Baier, G.Baier-Bitterlich, D.Looney, and A.Altman 1995. Immunogenic targeting of synthetic HIV-1 peptide vaccines to antigen-presenting cells by chimeric anti-MHC class II and anti-sIgD antibodies.J.Virology 69, 2357-2365.

 

28. G.Baier-Bitterlich, D.Fuchs, C.Murr, G.Reibnegger, G.Werner-Felmayer, G.Bˆck, M.P.Dierich, and H.Wachter, 1995. Effect of neopterin and 7,8-dihydroneopterin on programmed cell death induced by tumor necrosis factor alpha. FEBS Lett. 364, 234- 238.

 

29. V.Rudzite, J.Berzinsh, I.Grivane, D.Fuchs, G.Baier-Bitterlich, and H.Wachter 1996.

Serum tryptophan, kynurenine and neopterin in patients with Guillain-Barre-Syndrome (GBS) and with Multiple Sclerosis. Adv. Exp. Med. Biol. 398, 183-187.

 

30. V.Rudzite, E.Jurika, D.Fuchs, G.Baier-Bitterlich, and H.Wachter 1996. Kynurenine and pteridines in changes of membrane fluidity. Adv. Exp. Med. Biol. 398, 255-261.

 

31. C.Murr, G.Baier-Bitterlich, D.Fuchs, D.Gerlach, G.Werner-Felmayer, M.P.Dierich, and

H.Wachter 1996. Streptococcal erythrogenic toxins induce the formation of neopterin in human peripheral blood mononuclear cells via interferon-g. Immunobiol. 195, 314-322.

 

32. C.Murr, G.Baier-Bitterlich, D.Fuchs, E.Werner, H.Esterbauer, W.Pfleiderer, and H.Wachter 1996. Effects of neopterin-derivatives on H2O2-induced chemiluminescence: mechanistic aspects. Free Radicals in Biology and Medicine 21, 449-456.

 

33. V. Rudzite, E.Jurika, G.Baier-Bitterlich, H.Wachter, and D.Fuchs, 1996. Effect of 7,8- dihydroneopterin, biopterin and isoxanthopterin on cholesterol and phospholipid content and phospholipid biosynthesis in vitro. Pteridines 7, 24-28.

 

34. G.Baier-Bitterlich, D.Fuchs, R.Zangerle, P.A. Baeuerle, E.R.Werner, F.Fresser, F.‹berall, G.Baier, and H.Wachter, 1997. Transactivation of the HIV-1 promoter by 7,8- dihydroneopterin in-vitro. AIDS Res.Hum. Retrovir 13, 173-178.

 

35.G.Baier-Bitterlich, F.‹berall, B.Bauer, F.Fresser, H.Wachter, H.Grunicke, G.Utermann, A.Altman, and G.Baier 1996. PKC-t isoenzyme selective stimulation of the transcription factor complex AP-1 in T-Lymphocytes. Mol.Cell. Biol. 16, 1842-1850.

 

36. V.Rudzite, E.Jurika, G.Baier-Bitterlich, H.Wachter, and D.Fuchs, 1995. Effect of sepiapterin, 7,8-dihydrobiopterin, 5,6,7,8-tetrahydrobiopterin and xanthopterin on cholesterol and phospolipid content and phospholipid biosynthesis in vitro. Pteridines 6, 69-73.

 

37. J.Rappaport, S.K.Arya, M.W.Richardson, G.Baier-Bitterlich, and P.E.Klotman 1995. Inhibition of HIV-1 expression by HIV-2. J. Mol. Med.73, 583-589.

 

38. H.Schrˆcksnadel, G.Baier-Bitterlich, O.Dapunt, H.Wachter, and D.Fuchs 1996. Decreased plasma tryptophan in pregnancy. Obstet. Gynecol. 88, 47-50.

 

39. D.Fuchs, H.Schrˆcksnadel, G.Baier-Bitterlich, O.Dapunt, and H.Wachter 1996. Activated cellular immunity and decreased serum tryptophan in healthy pregnancy. Adv. Exp. Med. Biol. 398, 149-153.

 

40. G.Baier-Bitterlich, D.Fuchs, and H.Wachter 1996. 7,8-dihydroneopterin upregulates Interferon-g promoter in T-cells. Immunobiol. 196, 350-355.

 

41. G.Baier-Bitterlich, G.Baier, D.Fuchs, G.Bˆck, K.Khazaie, A.Hausen, G.Utermann, M.Pavelka, and H.Wachter 1996. The role of 7,8-dihydroneopterin in Adult T-Cell Leukemia. Oncogene 13, 2281-2285.

 

42. D.Fuchs, L.Dotevall, T.Gasse, L.Hagberg, G.P.Tilz, G.Baier-Bitterlich, U.Demel, E.Schmutzhard, and H.Wachter, 1996. Enhanced intrathecal neopterin production and tryptophan degradation in patients with Lyme neuroborreliosis. Acta Dermatovenerologica Alpina, Pannonica et Adriatica 5, 137-139.

 

43. A. Diez-Ruiz, A.A. Mˆller, G.Baier-Bitterlich, H.Wachter, and D.Fuchs, 1996. Neopterin production, degradation of tryptophan and neurologic impairment in human immunodeficiency virus infection. Pteridines 7, 29-34.

 

44. W. Schobersberger, G.Hoffmann, P. Hobisch-Hagen, G.Bˆck, H.Vˆlkl, G.Baier- Bitterlich, B.Wirleitner, H.Wachter, and D.Fuchs, 1996. Neopterin and 7,8- dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2. FEBS Lett. 397, 263-268.

 

45. G.P.Tilz, A.Diez-Ruitz, G.Baier-Bitterlich, U.Demel, H.Wachter, and D.Fuchs, 1996. Soluble receptors for tumor necrosis factor and neopterin as parameters of cell-mediated immune activation. Haematology 1, 141-154.

 

46. G.P.Tilz, A.Diez-Ruitz, G.Baier-Bitterlich, U.Demel, H.Wachter, and D.Fuchs, 1997.

Soluble receptors for tumor necrosis factor and neopterin as parameters of cell-mediated immune activation. Allergy Clin. Immunol. Int. 9, 110-118

 

47. G.Hoffmann, S.Kenn, B.Wirleitner, C.Deetjen, S.Frede, M.Smolny, J.Rieder, D.Fuchs, G.Baier-Bitterlich, and W.Schobersberger (1998). Neopterin induces nitric-oxide- dependent apoptosis in Rat vascular smooth muscle cells. Immunobiol. 199, 63-73.

 

48. V.Rudzite, E.Jurika, G.Baier-Bitterlich, B.Widner, G.Reibnegger, and D.Fuchs (1998). Pteridines and Lipid metabolism. Pteridines 9, 103-112.

 

49. B.Widner, G.Baier-Bitterlich, I.Wede, B.Wirleitner, and D.Fuchs, 1998. Neopterin derivatives modulate the nitration of tyrosine by peroxynitrite. Biochem. Biophys. Res. Comm. 248, 341-346.

 

50. B.Widner, G.Baier-Bitterlich, I.Wede, B.Wirleitner, H.Wachter, and D.Fuchs (1998). Neopterin: Indicator of oxidative stress and part of the cytotoxic armature of activated macrophages in Humans. Pteridines 9, 91-102.

 

51. B.Wirleitner, G.Baier-Bitterlich, G.Bˆck†, B.Widner, and D.Fuchs, 1998.

7,8-Dihydroneopterin-Induced Apoptosis in Jurkat T Lymphocytes:

A Comparison with Anti-Fas and Hydrogen Peroxide-Mediated Cell Death. Biochem. Pharmacol. 56, 1181-1187.

 

52. G.Baier-Bitterlich, A.Tretiakova A, M.W. Richardson, K.Khalili, B.Jameson, and J.Rappaport,1998. Structure and function of HIV-1 and SIV Tat proteins based on Carboxyterminal truncations, chimeric Tat constructs, and NMR modeling. Biomed Pharmacother. 52(10):421-30.

 

53. C.Murr, B.Widner, B.Wirleitner, G.Baier-Bitterlich, and D.Fuchs,1999. Neopterin als Prognoseparameter bei malignen Tumorerkrnakungen. J.Lab.Med. 23, 545-549.

 

54. B.Widner, C.Murr, B.Wirleitner, C.Mayr, N.Spˆttl, G.Baier-Bitterlich, and D.Fuchs, 1999. The importance of neopterin as a laboratory diagnostic marker of immune activation. Pteridines 10, 101-111.

 

55.A.Villunger, N.Ghaffari-Tabrizi, I.Tinhofer, N.Krumbock, B.Bauer, T.Schneider, S.Kasibhatla, R.Greil, G.Baier-Bitterlich, F.Uberall, D.Green, G.Baier 1999. Synergistic action of protein kinase C theta and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells. Eur J Immunol.29(11):3549-61.

 

56. K.Oettl, B.Wirleitner, G. Baier-Bitterlich, T.Grammer, F.Fuchs, G.Reibnegger. Formation of oxygen radicals in solutions of 7,8-dihydroneopterin. Biochem Biophys Res Commun. 1999 Oct 14;264(1):262-7.

 

57. F.Uberall, K.Hellbert, S.Kampfer, K.Maly, A.Villunger, M.Spitaler, J.Mwanjewe, G.Baier-Bitterlich, G.Baier, H.H.Grunicke, 1999. Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton. J Cell Biol. 144(3):413-25.

 

58. N. Ghaffari-Tabrizi, B.Bauer, A.Villunger, G.Baier-Bitterlich, A.Altman, G.Utermann, F.‹berall, and G.Baier, 1999. PKC-t, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T-cells. Europ.J.Immunol 29(1):132-42.

 

59. B.Widner, B.Wirleitner, G.Baier-Bitterlich, C.Murr, D.Fuchs, 1999. Neopterin-a laboratory diagnostic parameter for immune activation. FONS, Informacni Bulletin, Ceska Spolecnost Klinicke Biochemie 8: 32-41.

 

60. N. Spottl, B.Wirleitner, G.Bock, B.Widner, D.Fuchs, G.Baier-Bitterlich, 2000. Reduced pteridine derivatives induce apoptosis in human neuronal NT2/HNT cells.Immunobiology 201(3-4):478-91.

 

61. B.Widner, N. Sepp, E.Kowald, U.Ortner, B.Wirleitner, P.Fritsch, G.Baier-Bitterlich, D.Fuchs, 2000. Enhanced tryptophan degradation in systemic lupus erythematosus. Immunobiology 201(5):621-30.

 

62. B.Widner, B.Wirleitner, G.Baier-Bitterlich, G.Weiss, D.Fuchs, 2000. Cellular immune activation, neopterin production, tryptophan degradation, and the development of immunodeficiency. Arch. Immunol. Ther. Exp.48: 251-258.

 

63. B.Wirleitner, E.Kowald, B.Widner, U.Ortner, G.Baier-Bitterlich, N.Sepp, D.Fuchs. Soluble fas ligand amd neopterin in patients with systemic and cutaneous discoid lupus erythematosus. Pteridines 11:85-89.

 

64. C.Enzinger, B.Wirleitner, N.Spötl, G.Böck, D.Fuchs, G.Baier-Bitterlich, (2002). Reduced pteridine derivatives induce apoptosis in PC12 cells. Neurochemistry Int. 41(1):71-78.

65. Enzinger C, Wirleitner B, Bock G, Baier-Bitterlich G, Fuchs D. (2001). Influence of cytokines tumor necrosis factor-alpha and interferon-gamma on signaling cascades associated with apoptosis in rat PC12 cells. Neurosci Lett. 316(3):157-60.

 

66.  Wirleitner B, Czaputa R, Oettl K, Bock G, Widner B, Reibnegger G, Baier G, Fuchs D, Baier-Bitterlich G. (2001). Induction of apoptosis by 7,8-dihydroneopterin: involvement of radical formation.

Immunobiology. 203(4):629-41.

 

67.  Lutz C, Nimpf J, Jenny M, Boecklinger K, Enzinger C, Utermann G, Baier-Bitterlich G, Baier G. Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP). (2002) J Biol Chem. 2002 Nov 8;277(45):43143-51.

 

68.  Enzinger C, Wirleitner B, Lutz C, Bock G, Tomaselli B, Baier G, Fuchs D, Baier-Bitterlich G. (2002). 7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway. Eur J Cell Biol. 81(4):197-202.