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Curriculum vitae

Ao. Univ. Prof. Mag. Dr. Florian Überall, PhD, Retired

Nationality: Austrian Date of Birth: 30th April, 1954 Birthplace: Kitzbühel, Tyrol

Contact:

Center of Chemistry and Biomedicine Innsbruck
Division of Medical Biochemistry
Eco- & Nutritional Biochemistry & Nutrigenomics

Innsbruck Medical University
Innrain 80-82
6020 Innsbruck
Austria

PHONE: +43-512-9003-70120

FAX: ++43-512-9003-73130

email: florian.ueberall@i-med.ac.at

Memberships

• Austrian Society of Biochemistry and Molecular Biology (OGBM)
• Austrian Society of Genetic and Gene-Technology (OGGGT) Austrian Cancer Society (ACS)
• American Association for Cancer Research (AACR)
• Austrian Society for Phytotherapy (ÖGPhyt)
• Austrian Association of Molecular Life Sciences and Biotechnology (ÖGMBT)
• Advisory Board Member, TAM, Austrian Federal Ministry of Health

Scientific Advisor

• Co-Editor, Synergy, Elsevier 2013
• Editorial Board Journal of Phytomedicine – International Journal of Phytotherapy and Phytopharmacology
• Austrian Department of Health and Human Services (Ministry of Health)
• General Secretary, Austrian Society of Biochemistry and Molecular Biology
• EMBO Journal, FEBS Letters, J. Biol. Chemistry, Schweiz. Z. Ganzheitsmedizin

International Collaborators

• Altieri D, Department of Pathology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. Role of PKC isotypes in survivin expression;
• Biden T, Garvan Institute, Metabolic Diseases, Sydney Australia, Atypical PKC-iota in insulin signaling;
• Pestell R, Cornell University, New York, USA, Cyclin D1 signal transmission. Role of PKC isotypes;
• Ullrich A, MPI for Biochemistry, Martinsried, Germany, Signaling of Trk- and EGF receptor mutants;
• Ulrich-Merzenich G, Medizinische Poliklinik/Medizinische Klinik III, Bonn, Nutrigenomics, VOC signaling;
• Moscat Jorge, Sanford Burchham, La Jolla, USA, Role of atypical PKC in apoptosis and survival;
• Jörn Probst & Karin Bockelmann, Fraunhofer Insitute ISC, Würzburg, Germany, Biologicl functions of N-chlorotaurin;

Research interests

Nutrigenomic analysis - Systemic interactome - Nutrients => Genes => Health

Gene expression profiling, genome-wide network fingerprinting

Cellular analysis of volatile organic compounds - risk-benefit assessment

Signal transduction of natural compounds

Regulation of redox-sensitive genes

Ecological chemistry

Cancer signalling 

Lectures

262 invited lectures were held (in Austria & international e.g. in the USA, Germany, Switzerland, Italy, Spain and Turkey)

Selected publications (last five years)

• Becker K, Becker K, Fuchs D, Gostner J, Überall F. Immunomodulatory properties of cacao extracts – potential consequences of medical application. Frontiers in Pharmacology 2013, doi: 10.3389/fphar.2013.00154

• Becker K, Schroecksnadel S, Gostner J, Zaknun C, Schennach H, Ueberall F, Fuchs D. Comparison of in vitro tests for antioxidant and immunomodulatory capacities of compounds. Phytomedicine. 2013 Sep 13. pii: S0944-7113(13)00311-5. doi: 10.1016/j.phymed.2013.08.008

• Huemer HP, Geiger M, Posch W, Krumböck N, Fresser F, Wilflingseder D, Ueberall F. Protein kinase C overexpression does not enhance immune-stimulatory surface markers of vaccinia-infected dendritic cells and DC cell lines. Immunol Invest. 2013;42(2):164-77. doi: 10.3109/08820139.2012.750340.

• Klein A, Wrulich OA, Jenny M, Gruber P, Becker K, Fuchs D, Gostner J, Überall F. Pathway-focused bioassays and transcriptome analysis contribute to a better activity monitoring of complex herbal remedies. BMC Genomics 2013, 14:133

• Gostner JM, Schröcksnadel S, Becker K, Jenny M, Schennach H, Uberall F, Fuchs D. Antimalaria drug chloroquine counteracts activation of indolamine (2,3)-dioxygenase activity in human PBMC. FEBS Open Bio. 2012 Aug 17;2:241-5

• Crespo JA, Stöckl P, Ueberall F, Jenny M, Saria A, Zernig G. Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary fort he retrieval, consolidation and reconsolidation of drug memeory, PLoS One 2012, 7: e30502.
  
  
• Gostner J, Wrulich OA, Jenny M, Fuchs D, Ueberall F. An update on the strategies in multicomponent activity monitoring within the phytopharmacaeutical field. BMC Complement Altern Med., 2012, 14:12-18.
  
  
• Crespo JA, Stöckl P, Ueberall F, Jenny M, Saria A, Zernig G. Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memeory, PLoS One 2012, 7: e30502.
  
  
• Jenny M, Wondrak A, Zvetkova E, Ngoc Tram NT, Phi TP, Schennach H, Culig Z, Ueberall F, Fuchs D, Crinum latifolium leave extracts suppress immune activation cascades in peripheral blood mononuclear cells and proliferation of prostate tumor cells, Epub. (2011).
  
  
• Jenny M, Schroecksnadel S, Ueberall F, Fuchs D. The potential role of cannabinoids in modulating serotonergic signalling by their influence on tryptophan metabolism, Pharmaceuticals, 2010, 3: 2647-2660.
  
  
• Ciardi C, Jenny M, Tschoner A, Ueberall F, Patsch J, Pedrini M, Ebenbichler C, Fuchs D. Food additives sodium sulfite, sodium benzoate and curcumin inhibit leptin release in murine adipocytes in vitro, Epub, (2011).
  
  
• Morandell S, Grosstessner-Hain K, Roitinger E, Lindhorst T, Teis D, Wrulich AO, Mazanek M, Taus T, Ueberall F, Mechtler K, Huber LA. QIKS - Quantitative identification of kinase substrates. Proteomics, 2010, 10: 2015-2025.
  
  
• Maier E, Kurz K, Jenny M, Schennach H, Ueberall F, Fuchs D. Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro. Food Chem Toxicol., 2010, 48(7): 1950-1956.
  
  
• Narazenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schäfer R, Ueberall F, Sers C. Atypical Protein Kinase C z Exhibits a Proapoptotic Function in Ovarian Cancer. Mol Cancer Res., 2010, 8(6): 919-34.
  
  
• Schroecksnadel S, Jenny M, Kurz K, Klein A, Ledochowski M, Uberall F, Fuchs D. LPS-induced NF-kappaB expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun., 2010, 399: 642-646.
  
  
• Jenny M, Santer E, Klein A, Ledochowski M, Schennach H, Ueberall F, Fuchs D, Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells. Journal of Ethnopharmacology, 2009, 122:261-267.
  
  
• Malinowska K, Cavarretta IT, Susani M, Wrulich OA, Ueberall F, Kenner L, Culig Z. Identification of µ- crystallin as an androgen-regulated gene in human prostate cancer. The Prostate, 2009, 69: 1109-1118.
  
  
• Irschick EU, Haas G, Troger J, Ueberall F, Huemer HP. Involvement of protein kinase C in phagocytosis of human retinal pigment epithelial cells and induction of matrix metalloproteinase secretion. Int Ophthalmol., 2009, 5: 333-41.
  
  
• Gruber T, Fresser F, Jenny M, Ueberall F, Leitges M, Baier G. PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol., 2007, 45(1): 117-126.

12 selected publications of the entire working period

• Klein A, Wrulich OA, Jenny M, Gruber P, Becker K, Fuchs D, Gostner J, Überall F. Pathway-fossued bioassays and transcriptome abnalysis contribute to a better activity monitoring of complex herbal remedies. BMC Genomics 2013, 14:133

• Crespo JA, Stöckl P, Ueberall F, Jenny M, Saria A, Zernig G. Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memeory, PLoS One 2012, 7: e30502.

• Gostner J, Wrulich OA, Jenny M, Fuchs D, Ueberall F. An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field. BMC Complement Altern Med, 2012, 14:12-18.

• Morandell S, Grosstessner-Hain K, Roitinger E, Lindhorst T, Teis D, Wrulich AO, Mazanek M, Taus T, Ueberall F, Mechtler K, Huber LA. QIKS - Quantitative identification of kinase substrates. Proteomics, 2010, 10: 2015-2025.

• Gruber T, Fresser F, Jenny M, Ueberall F, Leitges M, Baier G. PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol., 2007, 45(1): 117-126.

• Sonja Kampfer, Michaela Windegger, Wolfgang Schwaiger, Richard G. Pestell, Gottfried Baier, Hans H. Grunicke, and Florian Überall. Protein kinase C isoforms involved in the transcriptional activation of Cyclin D1 by transforming Ha-Ras. J. Biol. Chem., 2001, 276: 42834-42842.

• Mwanjewe J, Spitaler, M, Kampfer S, Hofmann J, Florian Überall, and Grunicke H. Regulation of phospholipase D (PLD) isoenzymes by transforming Ras and atypical aPKC-iota. Biochem. J., 2001, 359: 211-217.

• Martin Spitaler, Andreas Villunger, Hans H. Grunicke and Überall F. Unique structural and functional properties of the ATP binding domain of atypical Protein kinas C-iota. J. Biol. Chem., 2000, 275: 33289-33296.

• Sonja Kampfer, Karina Hellbert, Andreas Villunger, Wolfgang Doppler, Gottfried Baier, G., Hans H. Grunicke, and Florian Überall. Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-iota, epsilon and zeta. EMBO J., 1998, 17: 4046-4055.

• Florian Überall, Karina Hellbert, Sonja Kampfer, Karl Maly, Andreas Villunger, Martin Spitaler, James Mwanjewe, Gottfried Baier, and Hans H., Grunicke. Evidence for an implication of atypical protein kinase C-lambda and in Ras-mediated reorganization of the F-actin cytoskeleton. J. Cell. Biol., 1999, 24: 23-34.

• Florian Überall, Karina Hellbert, Sonja Kampfer, Karl Maly, Andreas Villunger, Martin Spitaler, James Mwanjewe, Gottfried Baier, and Hans H. Grunicke. Induced reorganization of actin cytoskeleton is mediated by protein kinase C isoforms lambda and zeta. Nature Biotechnology Short Reports, 1999, 10: 51.

• Franz Hochholdinger, Gottfried Baier, Anto Nogalo, Birgitt Bauer, Hans H., Grunicke, and Florian Überall. Novel membrane-targeted ERK-1 and ERK-2 mutants which act as dominant negative, isotype-specific MAP kinase inhibitors of Ras-Raf-mediated transcriptional activation of c-fos in NIH3T3 cells. Mol. Cell. Biol., 1999, 19: 8052-8065.

Books

• Wrulich OW, Überall F, Nutrigenomik: Regulation der Genexpression durch Nährstoffe, Klinische Ernährungsmedizin, Ledochowski M, 2009, (Hrsg.), Springer Verlag, ISBN: 978-3-211-88899-5

• Überall A, Überall F: Herb- und Bitterstoffe, AT-Verlag Aarau, ISBN 978-3-03800-755-5

Reviews

• Becker K, Becker K, Fuchs D, Gostner J, Überall F. Immunomodulatory properties of cacao extracts – potential consequences of medical application. Frontiers in Pharmacology 2013, doi: 10.3389/fphar.2013.00154.

• Gostner JM, Gruber P, Becker K, Naschberger M, Uberall F. New approaches to elucidate the activities of botanical multi-component mixtures. Forsch Komplementmed. 2013;20 Suppl 2:41-4. doi: 10.1159/000351739. Epub 2013 Jun 21.

• Schroecksnadel S, Maier E, Jenny M, Kurz K, Ueberall F, Fuchs F. Beeinflussung immunologischer Regelkreise durch Konservierungsmittel und Farbstoffe in vitro, Allergologie, 2011, 34 (4): 200-211.

• Eder B, Überall F. Do chronic fatigue syndrome and atherosclerosis share common molecular risk factors. Schweiz Z Ganzheitsmed, 2011, 23: 109-120.

• Wrulich OA, Überall F. DNS-Mikroarrays- Verbesserung der analytischen Plattformen zur Beschreibung molekularer Wirkmuster von Naturstoffpräparaten oder Science Fiction? Schweiz Z Ganzheitsmed, 2009, 21: 348-355.

• Wrulich OA, Jenny M, Überall F. Molekulare Risiko- und Nutzenbewertung von Phytopharmaka. Neue Herausforderungen oder unerfüllbare Vorgaben?, J. Phytotherapie, 2009, 2: 7-13.

• Ueberall F, Fuchs D, Vennos Cecile. Das anti-inflammatorische Potential von Padma 28, Übersicht experimenteller Daten zur antiatherogenen Wirkung und Diskussion des Vielstoffkonzeptes, Forsch Komplementärmed, 2006, 13: 7-14.

• Jenny M, Wrulich OA, Schwaiger W, Überall F. Relevance of atypical protein kinase C isotypes in the drug discovery process. ChemBioChem, 2005, 6: 1-9.

• Geiger M, Wrulich OA, Jenny M, Schwaiger W, Grunicke HH, Überall F. Defining the human targets of phorbol ester and diacylglycerol, Current Opinion in Molecular Therapeutics, 2003, 5: 631-641.

• Hans H. Grunicke, Karl Maly, Inge Tinhofer, Sabine Giselbrecht, Sonja Kampfer, Gottfried Baier, and Florian Überall. Inhibition of phospholipase C and protein kinase C by alkyl-phosphocholines. Drugs of Today, 1998, 34: 100-113.

• Hans H. Grunicke, Karl Maly, Inge Tinhofer, Sabine Giselbrecht, Sonja Kampfer, Gottfried Baier, and Florian Überall. Inhibition of phospholipase C and protein kinase C by alkyl-phosphocholines. Drugs of Today, 1998, 34: 100-113.

• Geiger M, Wrulich OA, Jenny M, Schwaiger W, Grunicke HH, Überall F. Defining the human targets of phorbol ester and diacylglycerol, Current Opinion in Molecular Therapeutics, 2003, 5: 631-641.

• Jenny M, Wrulich OA, Schwaiger W, Überall F. Relevance of atypical protein kinase C isotypes in the drug discovery process. ChemBioChem, 2005, 6: 1-9.

• Ueberall F, Fuchs D, Vennos Cecile. Das anti-inflammatorische Potential von Padma 28, Übersicht experimenteller Daten zur antiatherogenen Wirkung und Diskussion des Vielstoffkonzeptes, Forsch Komplementärmed, 2006, 13: 7-14.

• Wrulich OA, Jenny M, Überall F. Molekulare Risiko- und Nutzenbewertung von Phytopharmaka. Neue Herausforderungen oder unerfüllbare Vorgaben?, J. Phytotherapie, 2009, 2: 7-13.

• Wrulich OA, Überall F. DNS-Mikroarrays- Verbesserung der analytischen Plattformen zur Beschreibung molekularer Wirkmuster von Naturstoffpräparaten oder Science Fiction? Schweiz Z Ganzheitsmed, 2009, 21: 348-355.

• Eder B, Überall F. Do chronic fatigue syndrome and atherosclerosis share common molecular risk factors. Schweiz Z Ganzheitsmed, 2011, 23: 109-120.

• Schroecksnadel S, Maier E, Jenny M, Kurz K, Ueberall F, Fuchs F. Beeinflussung immunologischer Regelkreise durch Konservierungsmittel und Farbstoffe in vitro, Allergologie, 2011, 34 (4): 200-211.