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Markus Nagl

Markus NAGL logo-orcid
Ao. Univ.-Prof. Dr.med.

Tel.: +43 (0)512 9003-70708
E-Mail: m.nagl@i-med.ac.at


Biographical sketch

Associate Professor, MD - Specialist for Hygiene and Microbiology - Qualification as General Practitioner - Special qualification for Clinical Trials - Qualified Person for pharmaceutical quality management


Current Position

Associate Professor, MD


Education

2011 Education in Pharmaceutical Quality Management, Qualified Person since 2012
2005 Specialist for Hygiene and Microbiology
2003 Associate Professor for Hygiene and Microbiology
2001 - present University Assistant at the Division of Hygiene and Medical Microbiology, University of Innsbruck
2000 - 2001 Schrödinger Research Fellow at the University College London (The Rayne Institute)
1998 Diploma for clinical studies (special education)
1997 - 1999 Research assistant at the Institute of Hygiene, University of Innsbruck
1997 Qualification as General Practitioner
1993 - 1996 Medical training in general medicine, University Hospital of Innsbruck
1992 - 1993 Assistant at the bone marrow transplantation subunit of the Department of Internal Medicine, University Hospital of Innsbruck
1992 Military service at the Military Hospital of Innsbruck
1991 Graduation as Medical Doctor, University of Innsbruck
1990 - 1991 Thesis at the Institute of Hygiene, University of Innsbruck, Start with the continuous research on N-chlorotaurine and other chloramines
1985 - 1991 University of Innsbruck Medical School, Austria

 

Projects

KLI459-B30 FWF Stand alone
Tolerability of inhaled N-chlorotaurine
in humans – a phase I clinical study
FWF 2015-2017

Aganocides and N-chlorotaurine –
preclinical studies

NovaBay
Pharmaceuticals, Inc.
2010-2012

L313-B13 FWF Stand alone

N-chlorotaurine applied to the bronchopulmonary system:
tolerability and antiinfective properties
FWF 2007-2009

P15240-MED FWF Stand alone

N-chlorotaurine applied to the bronchopulmonary system:
tolerability and antiinfective properties
FWF 2001-2004

P12298-MED FWF Stand alone

N-Chlorotaurine, a key substance in the human defence system: investigations
on the mechanism of its microbicidal
effect upon inflammation
FWF 1997-1999



Awards and Honors

Austrian Hygiene Prize (Österreichischer Hygienepreis), Nov. 1999

CAST Life Sciences Business Award 2004, 3rd prize. Jul. 2004

Rudolf Schülke Prize 2013 to Christian Mair and Markus Nagl and Austrian Hygiene Prize 2013 to Christian Mair (former name Eitzinger) for the study "Eitzinger C, Ehrlenbach S, Lindner H, Kremser L, Gottardi W, Debabov D, Anderson M, Nagl M, Orth D. N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli. PloS One 2012; 7: e47105," for which M. Nagl was senior and corresponding author

Themistocles Gluck-Preis 2014 to Débora Coraca-Huber for the study “Coraca-Huber DC, Ammann C, Fille M, Hausdorfer J, Nogler M, Nagl M. Bactericidal activity of N-chlorotaurine against biofilm forming bacteria grown on metaldiscs. Antimicrob Agents Chemother 2014; 58: 2235-9”, for which M. Nagl was senior and co-corresponding author.


Research Interests

Long-lived oxidants (chloramines) are produced by activated human granulocytes and monocytes. N-chlorotaurine, the main representative, is thought to be involved in termination of inflammation since it downregulates proinflammatory cytokines.

After synthesis of the pure sodium salt of N-chlorotaurine (NCT) by Waldemar Gottardi, we demonstrated its broad-spectrum microbicidal activity against bacteria, viruses, fungi, and protozoa. NCT may not only play a role in killing of pathogens at inflammatory sites, but it is also very well tolerated by human tissue and can be used in pharmacological doses as an antiseptic to treat infections of different body sites, e.g. conjunctivitis, otitis externa, sinusitis, purulently coated crural ulcers, urinary tract infections, organ abscesses, bronchopulmonary system.


Advantages are

endogenous occurrence
outstanding tolerability and usability in sensitive body regions and cavities
broad spectrum of microbicidal activity including all reigns of pathogens
absence of induction of resistance because of the oxidative reaction mechanism
therapeutic efficacy in different body sites if the infection can be treated topically
anti-inflammatory effects, induces downregulation of proinflammatory cytokines
enhancement of microbicidal activity in the presence of body fluids
immediate postantibiotic effect and loss of virulence of pathogens
inactivation of virulence factors of pathogens

 

Present research comprises basic science on the mechanisms of action and interactions as well as clinical studies on therapeutic application of NCT and other chloramines:

Direct activity of chloramines and bromamines against pathogens and mechanisms of action, tolerability by body cells, function in innate immunity

Clinical application of NCT
Clinical trials on the tolerability and efficacy of NCT in topical treatment of infections, e.g. conjunctivitis, otitis and sinusitis, leg ulcer and other skin and tissue infections, cystitis, organ abscesses.
Recently of high interest: bronchopulmonary system and inhalation of NCT.

Further occasional topics:
Activity of other antimicrobial agents (antibiotics, disinfectants ...).


Publications

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Teaching

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