Selected key scientific
findings,
Ernst R.
Werner, Division
of Biological Chemistry, Biocenter, Innsbruck Medical
University
* Identification of the gene encoding alkylglycerol
(glyceryl-ether) monooxygenase (2010) [>>PubMed]
* A novel assay for glyceryl-ether monooxygenase
(2007) [>>PubMed]
* Tetrahydrobiopterin derivatives suppress allograft rejection
(2006) [>>PubMed]
* 4-Amino tetrahydrobiopterin attenuates dendritic cell-induced
T-cell priming (2005) [>>PubMed]
* GTP cyclohydrolase I and its feedback regulatory protein are
oppositely regulated by lipopolysaccharide (2002) [>>PubMed]
* Ascorbate promotes endothelial cell nitric oxide formation by
tetrahydrobiopterin stabilisation (2001) [>>PubMed]
* Elucidation of mechanistic differences of
tetrahydrobiopterin-dependent enzymes by pterin analogues
(2000) [>>PubMed]
* Design of 4-amino tetrahydrobiopterin as potent pterin-site
inhibitor of nitric oxide synthase (1996) [>>PubMed]
* Synthesis of tritium-labelled tetrahydrobiopterin to study
tetrahydrobiopterin binding to nitric oxide synthase (1994)
[>>PubMed]
* GTP-cyclohydrolase I activity is the major site for cytokine
regulation of pteridine biosynthesis (1990) [>>PubMed]
* Proinflammatory cytokines induce tetrahydrobiopterin
synthesis and indoleamine 2,3-dioxygenase in human cells (1989)
[>>PubMed]
see also: >> Research interest, Ernst R. Werner; >> Research Summary, Division of Biological Chemistry