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Priv.-Doz. Ingo Bauer PhD, senior scientist

ingo_bauerEMail: ingo.bauer@i-med.ac.at

Phone: +43/(0)512/9003-70225

Fax: +43/(0)512-9003-73100

 

Short curriculum

2022

Habilitation (Venia docendi) in Molecular Biology

since 2022

Senior scientist at the Institute of Molecular Biology, Biocenter, Innsbruck Medical University

2007–2022

Postdoc at the Institute of Molecular Biology, Biocenter, Innsbruck Medical University

2004–2007

PhD thesis at the Division of Molecular Biology, Biocenter - Innsbruck Medical University.
Functional characterization of protein arginine methyltransferases in the filamentous fungus Aspergillus  nidulans

10/2002 

Start of Master thesis at the Department of Molecular Biology at the University of Innsbruck.
Biochemical, molecular and immunological identification and characterization of histone methyltransferases
and demethylases of Aspergillus nidulans

Summer 2001

Practical training at the Department of Microbiology at the University of Innsbruck.
Soil microbial biomass respiration measurement and community level physiological profiling

1997–2002

Studies in Microbiology at the University of Innsbruck

1996–1997

Civilian service

1991–1996

Bundeshandelsakademie Innsbruck

 

Research fields

 

Publications

  1. Moreno, S., Fickl, M., Bauer, I., Brunner, M., Rázková, A., Rieder, D., Delazer, I., Micura, R., Lusser, A. (2022). 6-thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells. J Med Chem, 65(22):15165–15173. doi: 10.1021/acs.jmedchem.2c01010

  2. Bauer, I., Abt, B., Yap, A., Leuchtle, B., Haas, H. (2022). Online Biomass Monitoring Enables Characterization of the Growth Pattern of Aspergillus fumigatus in Liquid Shake Conditions. J. Fungi 8, 1013. doi: 10.3390/jof8101013

  3. Karahoda, B., Pardeshi, L., Ulas, M., Dong, Z., Shirgaonkar, N., Guo, S., Wang, F., Tan, K., Sarikaya-Bayram, Ö., Bauer, I., Dowling, P., Fleming, A.B., Pfannenstiel, B.T., Luciano-Rosario, D., Berger, H., Graessle, S., Alhussain, M.M., Strauss, J., Keller, N.P., Wong, K.H., Bayram, Ö. (2022). The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis. Nucleic Acids Res 50(17):9797–9813. doi: 10.1093/nar/gkac744

  4. Schoberleitner, I., Mertens, B., Bauer, I., Lusser, A. (2022). Regulation of sensory perception and motor abilities by brain-specific action of chromatin remodeling factor CHD1. Front Mol Neurosci 15:840966. doi: 10.3389/fnmol.2022.840966

  5. Bauer, I. and Graessle, S. (2021). Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds. Genes 12,1470doi: 10.3390/genes12101470

  6. Schoberleitner I., Bauer I., Huang A., Andreyeva E.N., Sebald J., Pascher K., Rieder D., Brunner M., Podhraski V., Oemer G., Cázarez-García D., Rieder L., Keller M.A., Winkler R., Fyodorov D.V., Lusser A. (2021). CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan. Cell Rep 37, 109769. doi: 10.1016/j.celrep.2021.109769

  7. Dietl A.M., Binder U., Bauer I., Shadkchan Y., Osherov N., and Haas H. (2020).  Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of Aspergillus fumigatus. Genes 11, 0423. 2020. doi: 10.3390/genes11040423

  8. Birštonas, L., Dallemulle, A., López-Berges, M.S., Jacobsen, I.D., Offterdinger M., Abt B., Straßburger M., Bauer I., Schmidt O., Sarg B., Lindner H., Haas H., Gsaller F. (2020). Multiplex Genetic Engineering Exploiting Pyrimidine Salvage Pathway-Based Endogenous Counterselectable Markers. mBio 11, e00230–20. doi: 10.1128/mBio.00230-20

  9. Bauer, I., Gross S., Merschak, P., Kremser, L., Karahoda, B., Sarikaya Bayram, Ö., Abt, B., Binder, U., Gsaller, F., Lindner, H., Bayram, Ö., Brosch, G. and Graessle, S. (2020). RcLS2F – A Novel Fungal Class 1 KDAC Co-repressor Complex in Aspergillus nidulans. Front Microbiol 11:43. doi: 10.3389/fmicb.2020.00043

  10. Bauer, I., Misslinger, M., Shadkchan, Y., Dietl, A.M., Petzer, V., Orasch, T., Abt, B.,  Graessle, S., Osherov, N. and Haas, H. (2019). The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus. Front Microbiol 10:2773. doi: 10.3389/fmicb.2019.02773

  11. Orasch T., Dietl A.M., Shadkchan Y., Binder U., Bauer I., Lass-Flörl C., Osherov N., Haas H. (2019). The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus. Virulence 10, 925-934. doi: 10.1080/21505594.2019.1682760

  12. Bauer, I., Pidroni, A., Bayram, Ö., Brosch, G., Graessle, S. (2019). Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay. J Vis Exp 147: e59527. doi: 10.3791/59527

  13. Bauer, I., Lechner, L., Pidroni, A., Petrone, A., Merschak, P., Lindner, H., Kremser, L., Graessle, S., Golderer, G., Allipour, S. and Brosch, G. (2019). Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans. Fungal Genet and Biol 129, 86-100. doi: 10.1016/j.fgb.2019.05.006

  14. Binder U., Navarro-Mendoza M.I., Naschberger V., Bauer I., Nicolas F.E., Pallua J.D., Lass-Flörl C., Garre V. (2018). Generation of A Mucor circinelloides Reporter Strain-A Promising New Tool to Study Antifungal Drug Efficacy and MucormycosisGenes (Basel). pii: E613. doi: 10.3390/genes9120613

  15. Pidroni A., Faber B., Brosch G., Bauer I. and Graessle S. (2018). A Class 1 Histone Deacetylase as Major Regulator of Secondary Metabolite Production in Aspergillus nidulans. Front Microbiol 9:2212. doi: 10.3389/fmicb.2018.02212

  16. Bauer I., Varadarajan D., Pidroni A., Gross S., Vergeiner S., Faber B., Herrmann M., Tribus M., Brosch G., Graessle S. (2016). A class 1 histone deacetylase with potential as an antifungal target. mBio 7(6):e00831-16. doi: 10.1128%2FmBio.00831-16 

  17. Bauer, I., Graessle, S., Loidl, P., Hohenstein, K., Brosch, G. (2010). Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulansFungal Genetics and Biology 47(6):551-61. doi: 10.1016/j.fgb.2010.03.006  

  18. Castellano, S., Milite, C., Ragno, R., Simeoni, S., Mai, A., Limongelli, V., Novellino, E., Bauer, I., Brosch, G., Spannhoff, A., Cheng, D., Bedford, M.T., Sbardella, G. (2010). Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). Chem Med Chem 5(3), 398-414. doi: 10.1002/cmdc.200900459 

  19.  Bauer, I., Tribus, M., Galehr, J., Rieser, G., Brosch, G., Loidl, P., Trojer, P., Haas, H. and Graessle, S. (2010). A novel motif in fungal class 1 histone deacetylases is essential for growth and development of AspergillusMolecular Biology of the Cell Vol. 21, 345-353. doi: 10.1091/mbc.E09-08-0750

  20. Heinke R., Spannhoff A., Meier R., Trojer P., Bauer I., Jung M., and Sippl W. (2009). Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. Chem Med Chem 4(1):69-77. doi: 10.1002/cmdc.200800301

  21. Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schule R, Hanefeld W, Sippl W, Jung M. (2007). A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett 17, 4150-4153.  doi: 10.1016/j.bmcl.2007.05.088

  22. Ragno, R., Simeoni, S., Castellano, S., Vicidomini, C., Mai, A., Caroli, A., Tramontano, A., Bonaccini, C., Trojer, P., Bauer, I., Brosch, G. and Sbardella, G. (2007). Small Molecule Inhibitors of Histone Arginine Methyltransferases: Homology Modeling, Molecular Docking, Binding Mode Analysis and Biological Evaluations. J Med Chem 50, 1241-1253. doi:  10.1021/jm061213n

  23. Spannhoff, A., Heinke, R., Bauer, I., Trojer, P., Metzger, E., Gust, R., Schuele, R., Brosch, G., Sippl, W. and Jung, M. (2007). Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem 50, 2319-2325.  doi:  10.1021/jm061250e

  24. Trojer, P., Dangl, M., Bauer, I., Graessle, S., Loidl, P. and Brosch, G. (2004). Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity. Biochemistry 43, 10834-10843. doi: 10.1021/bi049626i

Institut für Molekularbiologie