Florian Überall, Ph.D.
STG-PKC Team- Überall
Network of protein kinase C function in proliferation, migration, cell survival, and programmed cell death.
People:
Florian Überall
Predoctoral studies at University of Innsbruck, Austria
PhD 1992 University of Innsbruck, Medical Chemistry
Postdoctoral work (1992)
Team Leader (since 1994)
Staff Scientist (1994)
Associate Professor for Medical Biochemistry (1999)
Secretary-General Austrian Society of Biochemistry
and Molecular Biology (since 1999)
Ebner Maria (Postdoctoral fellow)
Geiger Markus (PhD student)
Jenny Marcel (PhD student)
Nogalo Anto (Scientific assistant)
Spitaler Martin (Postdoctoral fellow)
Schwaiger Wolfgang (PhD student)
Windegger Michalea (Postdoctoral fellow)
Wrulich Oliver (PhD student)
Collaborators
Innsbruck
Auer B, Innsbruck (F205) Role of PKC isotypes in pADPRT signaling.
Baier G, Innsbruck Role of PKC isotypes in T-cell signal transduction pathways.
Doppler W, Innsbruck (F209) Prolactin signalling.
Fischer-Colbrie R, Innsbruck (F206A) Secretoneurin and actin function.
Hartl M, Innsbruck (F211) Ras homology proteins and LIM kinases.
Humpel CH, Innsbruck (F206B) Fos signaling in organotypic cell cultures.
Klocker H, Innsbruck (F203) Serine/threonine kinases in androgen receptor signaling.
Doppler W, Innsbruck (F209) Prolactin signalling.
Worldwide
Altieri D, Yale, USA Serine-threonine phosphorylation of survivin.
Biden T, Melborne, Australia, Atypical PKC-iota in insulin signaling.
Keyse S, London, UK Role of ERK specific phosphatases.
Mizukami, Tokyo, Japan PKC isotypes and reoxygenation.
Pestell R, New York, USA Cyclin D1 signal transmission. Role of PKC isotypes.
Troppmaier J, Würzburg, Germany Raf signaling networks.
Ullrich A, Martinsried, Germany Signaling of Trk- and EGF receptor mutants.
Research reports
Press Release
Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined acticvities of PKC-lambda,epsilon, and zeta
Evidence that protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.
Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras.
Research Interest
In living organisms, serine and threonine phosphorylation is associated with signaling pathways controlling a wide variety of processes including cellular growth, proliferation, differentiation, cell polarity, cytoskeletal architecture, stress response and apoptosis. Aberrant phosphorylation is detrimental for cell function and is associated with human disease. Protein kinase C isotypes (PKC) are central within these functions.
Since its discovery more than 10 years ago, the atypical PKC (aPKC) family has attracted great interest. Our group currently investigates aPKC function in cell proliferation, growth control, migration, apoptosis and cell survival induced by oncogenes.
We are part of EUROGENDIS and the group is interested in taking PhD students (EUROGENDIS, international PhD Programm)
The group takes part in the interdisciplinary research activities.
We are part of the research center (SFB) Molecular basis of inter- and intracellular signal transduction.
Our project is called Mitogenic signal transduction cascades. Role of protein kinase C and integrin-mediated signals in mitogenic signal transduction.
Contact
Address STGPKC-Team-Überall
Institute of Medical Chemistry and Biochemistry
Fritz Preglstrasse 3
A-6020 Innsbruck
AUSTRIA
Telephone: ++43-512-507-3536
FAX ++43-512-507-2872
http// www.stgpkc.com (very soon available in the web)
Keywords
Methods biochemistry; cellular transformation assasy;
cyctotoxicity assays; genetic screening;
immuno-fluorescence; kinase assays; PKC assays;
microinjection technique, reporter gene assays;
FACS analysis; "in vitro" translation
stable cell transfections; transient cell transfections,
Cyto-Trap, Y2H, two hybrid system
Molecules Abl; adaptor molecules p62/ZIP, HSP60-like, LIP,
Akt, MEK5, Par-4, Ha-Ras; PI3K;Ras-homology proteins Rac-1, RhoA;
Cellular Networks Anoikis, DNA damage-ATM-aPKC; cytoskeleton; Raf-MEK-ERK,
Ras-aPKC-cyclin D1; Ras-PLD1b-aPKC-PLD2
Ha-Ras>>
Teaching lectures and seminars
Practical courses Biochemische Übungen für Mediziner
VU3 / Block 508.101
Wissenschaftliches Arbeiten für
Fortgeschrittene
PV 10 508.149
Special lectures Spezielle Biochemie der Ernährung
VO2 / Block, 508.193
Interdisciplinary seminars Molekulare Signaltransduktion I-II
VU2 / Block, 508.148