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Publications in Journals, FWF Project 13793, Biochemistry of novel tetrahydrobiopterin derivatives
Ernst R. Werner, Division of Biological Chemistry, Biocenter,Medical University of Innsbruck

Nitric-oxide-mediated relaxations in salt-induced hypertension: effect of chronic b1-selective receptor blockade.Cosentino, F., Bonetti, S., Rehorik, R., Eto, M., Werner-Felmayer, G., Volpe, M., Lüscher, T. F. (2002) J.Hypertension 20, 421-428 

A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations in rats. Fitzal, F., Redl, H., Strohmaier, W., Werner, E. R., Bahrami, S. (2002) Shock 18, 158-162

Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. Werner, E. R., Bahrami, S., Heller, R., Werner-Felmayer, G. (2002)  J.Biol.Chem. 277, 10129-10133

Biopterin analogues: novel nitric oxide synthase inhibitors with immunosuppressive action. Werner, E. R., Werner-Felmayer, G. (2002) Curr.Drug.Metab. 3, 119-121

Prolongued survival of murine cardiac allografts by treatment with the 4-amino analogue of tetrahydrobiopterin. Brandacher, G., Zou, Y., Obrist, P., Steurer, W., Werner-Felmayer, G., Margreiter, R., Werner, E. R. (2001)  Transplant Proc. 33, 516-517

The 4-amino analogue of tetrahydrobiopterin efficiently prolongs murine cardiac allograft survival. Brandacher, G., Zou, Y., Obrist, P., Steurer, W., Werner-Felmayer, G., Margreiter, R., Werner, E. R. (2001)  J.Heart Lung Transpl. 20, 747-749

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin deficient mice. Cosentino, F., Barker, J. E., Brand, M. P., Heales, S. J., Werner, E. R., Tippins, J. R., West, N., Channon, K. M., Volpe, M., Lüscher, T. F. (2001) Arterioscler.Thromb.Vasc.Biol. 21, 496-502

Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase. Gorren, A. C. F., Kungl, A. J., Schmidt, K., Werner, E. R., Mayer, B. (2001) Nitric Oxide 5, 176-186

L-Ascorbic acid potentiates endothelial nitric oxide synthase via a chemical stabilization of tetrahydrobiopterin. Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner-Felmayer, G., Werner, E. R. (2001)  J.Biol.Chem. 276, 40-47

Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy. Schmidt, P. P., Lange, R., Gorren, A. C. F., Werner, E. R., Mayer, B., Andersson, K. K. (2001)  J.Biol.Inorg.Chem. 6, 151-158

Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue. Bahrami, S., Fitzal, F., Peichl, G., Gasser, H., Fuerst, W., Banerjee, A., Redl, H., Strohmaier, W., Werner-Felmayer, G., Werner, E. R. (2000) Shock 13, 386-391

Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. Golser, R., Gorren, A. C. F., Leber, A., Andrew, P., Habisch, H. J., Werner, E. R., Schmidt, K., Venema, R. C., Mayer, B. (2000) J.Biol.Chem. 275, 5291-5296

Low-temperature optical absorption spectra suggest a role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis. Gorren, A. C. F., Bec, N., Schrammel, A., Werner, E. R., Lange, R., Mayer, B. (2000)  Biochemistry 39, 11763-11770

Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyl tetrahydrobiopterin. Gorren, A. C. F., Schrammel, A., Riethmüller, C., Schmidt, K., Koesling, D., Werner, E. R., Mayer, B. (2000) Biochem.J. 347, 475-484

Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase.Werner, E. R., Habisch, H. J., Gorren, A. C. F., Schmidt, K., Canevari, L., Werner-Felmayer, G., Mayer, B. (2000) Biochem.J. 348, 579-583

Electronic structure of tetrahydropteridine derivatives.Reibnegger, G., Pauschenwein, J., Werner, E. R. (1999)  Pteridines 10, 91-94

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