Project Publications ,fwf P29551 Closing the crucial genetic gap in plasmalogen biosynthesis ,
Ernst R. Werner, Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck
Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase.
Werner ER, Fernández-Quintero ML, Hulo N, Golderer G, Sailer S, Lackner K, Werner-Felmayer G, Liedl KR, Watschinger K. Cell Mol Life Sci. 2022 Mar 28;79(4):214. doi: 10.1007/s00018-022-04238-w.
Unequivocal Mapping of Molecular Ether Lipid Species by LC-MS/MS in Plasmalogen-Deficient Mice.
Koch J, Lackner K, Wohlfarter Y, Sailer S, Zschocke J, Werner ER, Watschinger K, Keller MA. Anal Chem. 2020 Aug 18;92(16):11268-11276. doi: 10.1021/acs.analchem.0c01933
The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.
Werner ER, Keller MA, Sailer S, Lackner K, Koch J, Hermann M, Coassin S, Golderer G, Werner-Felmayer G, Zoeller RA, Hulo N, Berger J, Watschinger K. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7792-7798. doi: 10.1073/pnas.1917461117
A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates.
Werner ER, Keller MA, Sailer S, Seppi D, Golderer G, Werner-Felmayer G, Zoeller RA, Watschinger K. J Lipid Res. 2018 May;59(5):901-909. doi: 10.1194/jlr.D080283.