Publications, FWF Project 22289, Tetrahydrobiopterin and Ischemia-Reperfusion Injury,
Ernst R. Werner, Division of Biological Chemistry, Biocenter, Medical University of Innsbruck
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model. Maglione M, Oberhuber R, Cardini B, Watschinger K, Hermann M, Obrist P, Hengster P, Mark W, Schneeberger S, Werner-Felmayer G, Pratschke J, Margreiter R, Werner ER, Brandacher G. Am.J.Transplant. (2010) 10: 2231-2240
IDO and Regulatory T Cell Support Are Critical for Cytotoxic T Lymphocyte-Associated Ag-4 Ig-Mediated Long-Term Solid Organ Allograft Survival. Sucher R, Fischler K, Oberhuber R, Kronberger I, Margreiter C, Ollinger R, Schneeberger S, Fuchs D, Werner ER, Watschinger K, Zelger B, Tellides G, Pilat N, Pratschke J, Margreiter R, Wekerle T, Brandacher G. J.Immunol. (2012), 188: 37 - 46.
Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status. Ladurner A, Schmitt CA, Atanasov AG, Werner ER, Drisch VM, Heiss EH. Free Radic Biol Med (2012) 52: 2082 - 2090
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation. Schmidt K, Neubauer A, Kolesnik B, Stasch JP, Werner ER, Gorren AC Mayer B. Mol Pharmacol (2012), 82: 420 - 427
Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin. Maglione M, Cardini B, Oberhuber R, Watschinger K, Jenny M, Gostner J, Hermann M, Obrist P, Margreiter R, Pratschke J, Brandacher G, Werner ER. Transpl Int (2012), 25: 1024 - 1095
Interaction between Neuronal Nitric-Oxide Synthase and Tetrahydrobiopterin Revisited: Studies on the Nature and Mechanism of Tight Pterin Binding. Heine CL, Kolesnik B, Schmidt R, Werner ER, Mayer B, Gorren AC. Biochemistry (2014), 53: 1284 -1295.
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling. Schmidt K, Kolesnik B, Gorren AC, Werner ER, Mayer B. Biochem.Pharmacol. (2014), 90: 246 - 253.
Crucial Role for Neuronal Nitric Oxide Synthase in Early Microcirculatory Derangement and Recipient Survival following Murine Pancreas Transplantation.Cardini B, Watschinger K, Hermann M, Obrist P, Oberhuber R, Brandacher G, Chuaiphichai S, Channon KM, Pratschke J, Maglione M, Werner ER. PLoS.One. 2014; 9:e112570
Treatment With Tetrahydrobiopterin Overcomes Brain Death-Associated Injury in a Murine Model of Pancreas Transplantation. Oberhuber R, Ritschl P, Fabritius C, Nguyen AV, Hermann M, Obrist P, Werner ER, Maglione M, Florchinger B, Ebner S, Resch T, Pratschke J, Kotsch K. Am.J.Transplant. (2015), in press
