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Preparation documents for the Master's programme in Pharmaceutical Science - Drug Development and Regulatory Affairs (PHARM_SCI)

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1. Analytik

Which of the following statements related to the fundamentals of analytical chemistry are correct:

  • In adsorption chromatography elution speed can be modified by changing the polarity of the mobile phase. (correct)
  • With an UV-vis spectrophotometer only colored compounds can be determined. (wrong)
  • The resolution between two peaks should not be lower than 1.5 to consider both baseline separated. (correct)
  • Whether a compound is chiral or not can easily be determined with a refractometer. (wrong)

2. Chemistry

a) Please assign the following types of chemical bonds in the figure: covalent bond, hydrogen bond, ionic bond, coordinate bond

Correct answer: 

 

b) Single choice: How much solid sodium hydroxide (MW = 40.0 g/mol) do you need to neutralize 100 ml of 1M (= 1 mol/L) hydrochloric acid (MW = 36.5 g/mol)?

Drop down Optionen:

  • 0.4 g
  • 4.0 g
  • 3.65 g
  • 36.5 g

Correct answer: 4.0 g

3. Statistics

Question 1: There is a population of 100 observation units.  The mean, median, variance and range (range = maximum-minimum) are determined from a random sample of size n=10. Then another 10 observation units are selected from the same population and the descriptive statistics for the resulting total sample of 20 are calculated. Which of the following cannot be reduced under any circumstances?

a) Mean
b) Median
c) Variance
d) Range
e) Standard deviation

Correct answer: d)

 

Question 2: In order to get a new drug approved, which type of study is preferable?

a) A randomized controlled trial
b) A case-control study
c) A cohort study
d) A cross-sectional study

Correct answer: a)

4. Molecular Biology

What is a vector vaccine?

a) a genetically engineered ”transport virus” which carries the gene encoding the actual vaccine 
b) an inactivated virus that is unable to infect human cells
c) a bacterial virus (bacteriophage) that is unable to infect human cells
d) a directly applied viral messenger-RNA (mRNA) encoding a vaccine
e) a bacterially-produced antigenic protein

Correct answer: a)

5. Physiology and pathophysiology

Why does a deficiency in Vitamin K increase the chance of bleeding?

a) Reduced aggregation of platelets
b) Platelets are not able to adhere to endothelial cells
c) Due to a liver failure, less prothrombin is synthesized
d) Reduced gamma-carboxylation of prothrombin

Correct answer: d)

6. Genetics

Breeding of a homozygous wild-type mother and a homozygous knockout father results in which distribution of genotypes in the F2 generation?
According to Mendelian laws, the genotypes split into:    % homozygous wild-type,        % homozygous knockout,        % heterozygous

fill in appropriate numbers from this list. 0 %; 10 %;  25 %; 33 %; 50 %; 80 %

Correct answer: 25; 25; 50 in that order.

 

7. Pharmacology 

What is efficacy?

a) The maximal biological effect of a drug
b) The ability of a drug to bind a receptor
c) If a drug binds only one receptor
d) The strength of the drug-receptor binding

Correct answer: a)

8. Pharmaceutical Technology

General guidelines for the peroral intake of drug products:

Take medicines with plenty of water – correct
Enteric-coated tablets to be taken in the “fasted” state – correct
Breaking up sustained-release (diffusion coating) or enteric-coated Tablets before administration is allowed - false
For a fast effect perorally applied medicines should be administered with food – false

9. Biotechnology

Parenteral formulation are dosage forms are administered / most common routes 

- Oral (wrong)
- Subcutaneous (correct)               
- Intravenous Subcutaneous (correct)
- Intramuscular Subcutaneous (correct)
- Intrathecal Subcutaneous (correct) 

Erstzulassung

Kontakt

 

 

Aufnahmeverfahren

 

aufnahmeverfahren@i-med.ac.at


Denise Gredler, BA

 

Zi. Nr.: 04-230

kein Parteienverkehr

 

 

 

Zulassung

 

studienabteilung@uibk.ac.at

 

Mag. Pelageh Ladstätter, Bsc.
Lehrgangskoordinatorin
Universität Innsbruck
Innrain 52
6020 Innsbruck

 

 

Kontakt

 

 

Aufnahmeverfahren

 

aufnahmeverfahren@i-med.ac.at


Denise Gredler, BA

 

Zi. Nr.: 04-230

kein Parteienverkehr

 

 

 

Zulassung

 

studienabteilung@uibk.ac.at

 

Mag. Pelageh Ladstätter, Bsc.
Lehrgangskoordinatorin
Universität Innsbruck
Innrain 52
6020 Innsbruck