Group: Molecular and Cellular Biology
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Head, Jakob Troppmair, PhD
Professor of Molecular Transplantation Biology
Members of the group: Martina Haller MSc; Marion Enthammer MSc; Katarzina Koziel MSc, Martin Deutsch MSc, Astrid Drasche; Tina Burtscher
Research Focus:
The goal of our work is to understand cellular signaling and its role in the determination of cell fate in terms of proliferation, survival, etc. under normal and patho-physiological conditions.
Our interest lies in the dissection of intracellular signaling pathways and of the mechanism controlling signal propagation along them. Historically, this work focused on mitogen- activated protein kinases (MAPKs), but other signaling entities (NF-KB, PI-3-kinase, protein kinase B) are also studied. Of particular interest to us is to use this knowledge to further understand and eventually control aberrant signaling in diseases such as cancer, ischemie/reperfusion or neurodegeneration.
Research projects:
- Analysis of mechanisms underlying the survival control by Raf and PKB
- Regulation of ischemia/reperfusion (I/R) induced tissue damage by MAPKs
- Role of Raf and Raf effector pathways in malignant transformation
- Stress kinase signaling in transformation
Publications of Troppmair Jakob (PubMed)