PD Dr. IMRICH BLASKO
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Tel.: +43/512/504-23636 |
Funktionen und Verantwortungsbereiche:
Facharzt für Psychiatrie, Diplom für Psychosomatische Medizin (PSY-II)
Oberarzt an der Universitätsklinik für Psychiatrie
Abteilung für Allgemeine Psychiatrie
Wissenschaft:
Mitglied der Demenz-Forschungsgruppe (Leiter: Ao. Univ.Prof. Dr. Josef Marksteiner)
Mitglied des Teams der Gedächtnisambulanz
Lehre:
Pflichtpraktika für Medizinstudenten
Key papers:
Blasko I, Knaus G, Weiss E, Kemmler G, Winkler C, Falkensammer G, Griesmacher A, Wurzner R, Marksteiner J, Fuchs D. Cognitive deterioration in Alzheimer's disease is accompanied by increase of plasma neopterin. Journal of Psychiatric Research 2007; 41: 694-701.
Blasko I, Jellinger K, Kemmler G, Krampla W, Jungwirth S, Wichart I, Tragl KH, Fischer P. Conversion from cognitive health to mild cognitive impairment and Alzheimer’s disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine. Neurobiology of Aging 2006.
Blasko I, Lederer W, Oberbauer H, Walch T, Hinterhuber H, Marksteiner J, Humpel Ch. Measurement of thirteen biological markers in CSF of patients with Alzheimer’s disease: focus on MCP-1 and NGF. Dementia and Geriatric Cognitive Disorders 2006; 21(1): 9-15.
Blasko I, Kemmler G, Krampla W, Jungwirth S, Wichart I, Jellinger K, Tragl KH, Fischer P. Plasma Amyloid beta protein 42 in non-demented persons aged 75-years: Effects of concomitant medication and medial temporal lobe atrophy. Neurobiology of Aging 2005; 26(8): 1135-43.
Mitgliedschaften:
Österreichische Gesellschaft für Psychiatrie und Psychotherapie
Österreichische Gesellschaft für Neurowissenschaften
Gesamte persönliche Publikationsliste: (optional)
I. Originalien:
1. Blasko I, Bodner T, Knaus G, Walch T, Monsch A, Hinterhuber H, Marksteiner J (2004): Efficacy of donepezil treatment in Alzheimer patients with and without subcortical vascular lesions; Pharmacology 72(1): 1-5.
2. Blasko I, Beer R, Bigl M, Appelt J, Franz G, Rudzki D, Ransmayr G, Kampfl A, Schliebs R (2004): Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer’s disease b-secretase (BACE-1); Journal of Neural Transmission 111(4): 523-36.
3. Saurwein-Teissl M, Lung TL, Marx F, Gschösser C, Asch E, Blasko I, Parson W, Böck G, Schönitzer D, Trannoy E, Grubeck-Loebenstein B (2002): Lack of antibody production following immunization in old age: association with CD8+CD28- T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines; Journal of Immunology 168(11): 5893-9.
4. Blasko I, Apochal A, Hartmann T, Boeck G, Grubeck-Loebenstein B, Ransmayr G (2001): NSAID Ibuprofen decreases the cytokine-induced production of Amyloid beta peptides; Neurobiology of Disease 8(6): 1094-101.
5. Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B (2000): Costimulatory effects of interferon-gamma and interleukin-1b or tumor necrosis factor alpha on the synthesis of Ab 1-40 and Ab 1-42 by human astrocytes; Neurobiology of Disease 7(6): 682-689.
6. Blasko I, Wagner M, Whitaker N, Grubeck-Loebenstein B, Jansen-Dürr P (2000): The amyloid beta peptide Ab (25-35) induces apoptosis independent of p53; FEBS Letters 2(470): 221-225.
7. Blasko I, Sztankay A, Lukas P, Grubeck-Loebenstein B (1999): Decreased thyroid peroxidase expression in cultured thyrocytes after external gamma irradiation; Experimental and Clinical Endocrinology & Diabetes 2(108): 138-41.
8. Marx F, Blasko I, Zisterer K, Grubeck-Loebenstein B (1999): Transfected human B cells: a new model to study the functional and immunstimulatory consequences of APP production; Experimental Gerontology 34(6): 783-795.
9. Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B (1999): TNFa plus IFNg induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs; FASEB Journal 13(1): 63-68.
10. Schwingshackl A, Blasko I, Steiner E, Pozzilli P, Cavallo MG, Berger P, Grubeck-Loebenstein B (1998): Sex steroids do not prevent amylin-induced apoptosis in human cells; Experimental Cell Research 241(1): 265-268.
11. Niederwolfsgruber E, Schmitt TL, Blasko I, Trieb K, Steger MM, Maczek C, Hager J, Bobak K, Steiner E, Grubeck-Loebenstein B (1998): The production of the Alzheimer amyloid precursor protein (APP) in extraneuronal tissue does not increase in old age; Journals of Gerontology, Biological and Medical Sciences 53(3): B186-190.
12. Blasko I, Schmitt TL, Steiner E, Trieb K, Grubeck-Loebenstein B (1997): Tumor necrosis factor-a augments amyloid b (25-35) induced apoptosis in human cells; Neuroscience Letters 238(1-2): 17-20.
II. Übersichtsartikel:
1. Blasko I, Stampfer-Kountchev M, Robatscher P, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B (2004): How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes; Aging Cell 3(4): 169-76.
2. Blasko I, Grubeck-Loebenstein B (2003): The role of the immune system in the pathogenesis, prevention and treatment of Alzheimer’s disease; Drugs & Aging 20(2): 101-13.
3. Wick G, Jansen-Dürr P, Berger P, Blasko I, Grubeck-Loebenstein B (1999): Diseases of aging; Vaccine 16(18): 1567-83.
4. Marx F, Blasko I, Grubeck-Loebenstein B (1999): Mechanism of immune regulation in Alzheimer's disease: a viewpoint; Archivum Immunologie et Therapiae Experimentalis 47: 205-209.
5. Marx F, Blasko I, Pavelka M, Grubeck-Loebenstein B (1998): The possible role of the immune system in Alzheimer's disease; Experimental Gerontology 33(7-8): 871-881.
III. Letters to the Editor, Editorials, Kommentare etc.:
1. Blasko I, Grubeck-Loebenstein B (2003): Vaccination against Alzheimer’s disease? Wiener Klinischer Wochenschrift 115(9): 279-80.
2. Blasko I, Ransmayr G, Veerhuis R, Eikelenboom E, Grubeck-Loebenstein B (2001): Does IFNg play a role in neurodegeneration? Journal of Neuroimmunology 116: 1-4.
3. Saurwein-Teissl M, Blasko I, Zisterer K, Neuman B, Lang B, Grubeck-Loebenstein B (2000): An imbalance between pro- and anti-inflammatory cytokines, a characteristic feature of old age; Cytokine 7(12): 1160-1.
4. Grubeck-Loebenstein B, Blasko I, Marx F, Trieb K (2000): Immunization with Amyloid b to prevent Alzheimer's disease: Could T cell activation have harmful effect? Trends in Neurosciences 3(23): 114.
5. Blasko I, Marx F, Grubeck-Loebenstein B, Marksteiner J (1999): Abnormalities of beta-amyloid precursor protein expression in platelets of patient with Alzheimer’s disease - do we understand them well enough? Archives of Neurology 56: 889-890.
IV. Bücher, Buchbeiträge, Proceedings:
1. Blasko I, Grubeck-Loebenstein B, Humpel C (2008): Cell biology of normal brain aging: Glia - astrocytes and oligodendroglia. In: Encyclopedia of Neurosciences, L.R. Squire (eds.), Elsevier Ltd, Oxford, United Kingdom (in press).