Arbeitsgruppe Intensivneurologie -
Research Division Neurological Intensive Care
Die Arbeitsgruppe Neurologische Intensivmedizin hat sich zum Ziel gesetzt, in Patientenversorgung, Forschung und Lehre (prä- und postgraduale Aus- und Weiterbildung) für ihre beiden Komponenten, nämlich :
- akute neurologische Erkrankungen des Gehirns und peripheren Nervensystems und
die intensivmedizinischen Versorgungsstrategien in bezug auf Diagnostik, Monitoring und Therapie
einen gemeinsamen Nenner zu bringen
The declared goals of the research division for neurological intensive care are medical care, research and teaching (pre- and postgraduate) for both of its components:
- acute neurological diseases of the brain and the peripheral nerval system
- strategies for neurological intesive care concerning diagnosis, monitoring and therapy
Leistungsbericht / Publications
Dissertation / Dimplomarbeit
Mitarbeiter: Univ.-Prof.Dr. E. Schmutzhard Univ.-Doz. Dr. Bettina Pfausler Dr. R. Beer |
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Highlights
Klinische Intensiv- und Infektionsneurologie
| Kampfl A, Schmutzhard E, Franz G, Pfausler B, Haring HP, Ulmer H, Felber S, Golaszewski S, Aichner F.(1998) Prediction of recovery from post-traumatic vegetative state with cerebral magnetic-resonance imaging.Lancet |
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Cerebral MRI findings in the subacute stage after head injury can predict the outcome of the post-traumatic vegetative state. Corpus callosum and dorsolateral brainstem lesions are highly significant in predicting non-recovery.
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Schmutzhard E, Engelhardt K, Beer R, Brossner G, Pfausler B, Spiss H, Unterberger I, Kampfl A.(2002) Safety and efficacy of a novel intravascular cooling device to control body temperature in neurologic intensive care patients: a prospective pilot study. Crit Care Med. |
Franz G, Beer R, Kampfl A, Engelhardt K, Schmutzhard E, Ulmer H, Deisenhammer F.(2003) |
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Aß-42 and tau may play a potential role in the pathophysiology of TBI. Furthermore, the results of this study suggest that Aß-42 may be a supportive early predictor for recovery after severe head injury.
Helbok R, Dent W, Nacher M, Lackner P, Treeprasertsuk S, Krudsood S, Wilairatana P, Silachamroon U, Looareesuwan S, and Schmutzhard E (2005) The use of the multi-organ-dysfunction score to discriminate different levels of severity in severe and complicated Plasmodium falciparum malaria. Am J Trop Med Hyg, 72: 150-154 |
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The Multi-Organ-Dysfunction Score is applied in the evaluation of the clinical severity of complicated Plasmodium falciparum malaria, and shown provide a predictive value for morbidity and disease duration.
Experimentelle Intensiv- und Infektionsneurologie
Beer R, Franz G, Krajewski S, Pike BR, Hayes RL, Reed JC, Wang KK, Klimmer C, Schmutzhard E, Poewe W, Kampfl A.(2001) |
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Our findings also suggest a contributory role of caspase 8 activation to caspase 3 mediated apoptotic cell death after experimental TBI in vivo.
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Franz G, Beer R, Intemann D, Krajewski S, Reed JC, Engelhardt K, Pike BR, Hayes RL, Wang KK, Schmutzhard E, Kampfl A.(2002) Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury.J Cereb Blood Flow Metab. |
The results provide the first evidence of Bid cleavage in the traumatized cortex after experimental traumatic brain injury in vivo, and demonstrate that tBid is expressed in neurons and glial cells. Further, findings indicate that cleavage of Bid may be associated with the activation of the initiator caspase-8 and caspase-9. Finally, these data support the hypothesis that cleavage of Bid contributes to the apoptotic degeneration of different CNS cells in the injured cortex.
Lackner P, Beer R, Heussler V, Goebel G, Rudzki D, Helbok R, Tannich E, Schmutzhard E (2006): Behavioural and histopathological alterations in mice with cerebral malaria; Neuropathol. Appl. Neurobiol. (in press) |
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Different features of sensorimotor function and behaviour were studied in murine cerebral malaria and malaria without cerebral involvement applying a well know scoring system for neurological functions in mice. Functional characterisation of animals suffering from cerebral malaria might prove useful in the preclinical assessment of new antimalarial and potential neuroprotective therapies.