Division of Clinical Neurobiology

Clinical Research

Neurogenic orthostatic hypotension

• Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. 
• Orthostatic hypotension and attention in Parkinson's disease with and without dementia. 

Diagnosis of MSA

• Second consensus statement on the diagnosis of multiple system atrophy. 
• Red flags for multiple system atrophy. 
• Recent developments in multiple system atrophy. J Neurol. 2009 in press. 

Biomarkers of MSA

• Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphy. 
• Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease. 
• Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study. 
• Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study.  

Therapeutic Trials in MSA

• Minocycline 1-year therapy in multiple-system-atrophy
• Placebo-controlled trial of riluzole in multiple system atrophy. 
• Safety and tolerability of growth hormone therapy in multiple system atrophy: a double-blind, placebo-controlled study. 

Research Programme of the European MSA Study Group

• Final analysis of the European multiple system atrophy registry
• Red flags for multiple system atrophy 
• Progression of dysautonomia in multiple system atrophy: a prospective study of self-perceived impairment 
• Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG) 
• The alpha-synuclein gene in multiple system atrophy 
• Health-related quality of life in multiple system atrophy 
• The European Multiple System Atrophy-Study Group (EMSA-SG) 
• UCHL-1 gene in multiple system atrophy: a haplotype tagging approach 
• The fragile X tremor ataxia syndrome in the differential diagnosis of multiple system atrophy: data from the EMSA Study Group 

Division of Clinical Neurobiology - Department of Neurology 
Innsbruck Medical University - Anichstr. 35 - 6020 Innsbruck - Austria

Phone: +43 (0)512 504-81 811 (direct) - Fax: +43 (0)512 504-23912 - email: gregor.wenning@i-med.ac.at