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Florian Überall, Ph.D.
Selected References
Kampfer S, Hellbert K, Villunger A, Doppler W, Baier G, Grunicke HH, and Überall F (1998) Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined acticvities of PKC-lambda, epsilon, and zeta. EMBO J 17: 4046-4055.
Überall F, Hellbert K, Kampfer S, Maly M, Villunger A, Spitaler M, Mwanjewe J, Baier-Bitterlich G, Baier G and Grunicke H (1999) Evidence that protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton. J Cell Biol 144: 413-25.
Überall F, Hellbert K, Kampfer S, Maly K, Villunger, Spitaler M, Mwanjewe J, Baier G, and Grunicke H (1999) Induced reorganization of actin cytoskeleton is mediated by protein kinase C isoforms lambda?and zeta. Nature Biotechnology Short Reports 10: 51.
Hochholdinger F, Baier G, Nogalo A, Bauer B, Grunicke H, and Überall F (1999) Novel Membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-raf-mediated transcriptional activation of c-fos in NIH 3T3 cells. Mol Cell Biol 19, 8052-8065.
Ghaffari-Tabrizi N, Bauer B, Villunger A, Baier-Bitterlich G, Altman A, Utermann G, Überall F and Baier G (1999) Protein kinase C-theta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells. Eur. J. Immunol 29, 132-142.
Spitaler M, Villunger A, Grunicke H and Überall F (2000) Unique structural and functional properties of the ATP binding domain of atypical Protein kinase C-iota. J Biol Chem 275, 33289-33296.
Bauer B, Krumböck N, Ghaffari-Tabrizi N, Kampfer S, Villunger A, Wilda M, Hameister H, Utermann G, Leitges M, Überall F, Baier G (2000) T cell expressed PKC-theta demonstrates cell-type selective function. Eur. J. Immunol 30, 3645-3654.
Bauer B, Fresser, F, Krumböck, N., Hochholdinger F, Spitaler, M, Simm A, Überall F, Schraven B, Baier G (2001) Complex formation and cooperation of PKC-theta and Akt1/PKB-alpha in the transactivation of the IKKbeta/IkappaB/NFkappaB signaling cascade in Jurkat T cells, J Biol Chem 276, 31627-31634.
Glading A, Überall F, Keyse S, Lauffenburger DA and Wells A (2001) Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. J. Biol Chem 276, 23341-23348.
Grunicke H, Kampfer S, Spitaler M, Hochholdinger F, Baier G and Überall F (2001) Elements of signal transduction in drug discovery with special reference to inhibitors of protein kinase C. Ernst Schering Res Found Workshop 43, 81-99.
Mwanjewe J, Spitaler M, Ebner M, Windegger M, Geiger M, Kampfer S, Hofmann J, Überall F and Grunicke H (2001) Regulation of phospholipase D isoenzymes by transforming Ras and atypical PKC-iota. J. Biochem [epub ahead of print].
Kamper S, Windegger M, Hochholdinger F, Schwaiger W, Pestell RG, Baier G, Grunicke H and Überall F (2001) Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras. J. Biol Chem Sep 10 [epub ahead of print].