Biocenter, Area Biochemistry and Chemistry
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Johann Hofmann, Ph.D.
Publications:
- Shishkin A. A, Ivanov O. G., Zaitsev A. V., Kononova E. G., Malinina E. A., Ol'shevskaya V. A., Kalinin V. N., Hofmann J., Shtil A. A. The copper-containing monocarboranylporphyrin: a prototype of new DNA-binding cytotoxic compounds. Dokl. Biochem. Biophys., 403, 313-316. 2005.
---- - Ol’shevskaya, V.A., Zaitsev, A.V., Luzgina, V.N., Kondratieva, T.T., Ivanov, O.G., Kononova, E.G., Petrovskii, P.V., Mironov, A.F., Kalinin, V.N., Hofmann, J., and Shtil, A.A. Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: synthesis and toxicity for anticancer drug resistant tumor cells. Bioorg. Med. Chem., 14, 109-120, 2006.
---- - Garczarczyk, D., Rechfeld, F., Hechenberger, G., and Hofmann, J. Protein kinase C isozymes – targets for potential therapies. DOSIS, 22, 93-103, 2006
---- - Easmon, J., Pürstinger, G., Thies, K, Heinisch, G. and Hofmann, J. Synthesis, structure activity-relationships and antitumor studies of 2-benzoxazolyl hydrazones derived from ?-(N)-acyl heteroaromatics. J. Med. Chem., 49, 6343-6350, 2006
---- - Lamy, C., Hofmann, J., Parrot-Lopez, H., and Goekjian, P. Synthesis of a fluoroalkene peptidomimetic precursor of N-acetyl-L-glutamyl-L-alanine. Tetrahedron Lett., 48, 6177-6180, 2007
---- - Perkhofer, S., Kehrel, B.E., Dierich, M.P., Donnelly, J.P., Nussbaumer, W., Hofmann, J., von Eiff, C., Lass-Florl, C. Human platelets attenuate Aspergillus species via granule-dependent mechanisms. J. Infect Dis., 198, 1243-1246, 2008
---- - Hofmann, J. Resistance to chemotherapy. Brit. J. Cancer, 99, 1368, 2008
-- - Hofmann, J., Easmon, J., Pürstinger, G., Heinisch, G., Condorelli, D. F., Musumarra, G., Jenny, M., Shtil, A., and Scire, S. Investigations on the mechanism of action of the new antitumor compound EPH136. Invest. New Drugs, 27, 189-202, 2009
---- - Garczarczyk, D., Toton, E., Biedermann, V., Rosivatz, E., Rechfeld, F., Rybczynska, M., and Hofmann, J. Signal transduction of constitutively active protein kinase C epsilon. Cell Signal., 21, 745–752, 2009
---- - Radford, D.J. Wang, K., McNelis, J.C., Taylor, A.E., Hechenberger, G., Hofmann, J., Chahal, H., Arlt, W., and Lord, J.M. Dehdyroepiandrosterone Sulfate Directly Activates Protein Kinase C-? to Increase Human Neutrophil Superoxide Generation. Mol. Endocrinol. 24, 813-821, 2010
---- - Garczarczyk, D., Szeker, K., Galfi, P., Csordas, A., and Hofmann J. Protein kinase C? in colon cancer cells: Expression, Thr514 phophorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation. Chem. Biol. Interact. 185, 25-32, 2010.
---- - Rechfeld, F., Gruber, P., Hofmann, J., and Kirchmair, J. Modulators of protein-protein interactions – novel approaches in targeting protein kinases and other pharmaceutically relevant biomolecules. Curr. Topics Med. Chem. In press
---- - Mair, N., Leitner, M.G., Benetti, C., Quarta, S., Constantin, C.E., Schweigreiter, R., Garczarczyk, D., Biasio, W., Andratsch, M., Hofmann, J., Gibbins, I.L., Kress, M. and Haberberger, R.V. Sphingosine-1-phosphate augments pain sensitivity through neuronally expressed metabotropic sphingosine-1-phosphate receptors. Submitted
---- - Toton, E., Lisiak, N., Rubis, B., Budzianowski, J., Gruber, P., Hofmann, J. and Rybczynska, M. The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by a Bcl-2, PARP-1, c-Jun and c-Fos decrease. Submitted
---- - Gruber, P., Rechfeld, F., Kirchmair, J., Hauser, N., Boehler, M., Garczarczyk, D., Langer, T. and Johann Hofmann The barbituric acid derivative BAS 02104951 inhibits PKC?, PKC? and PKC?/RACK2 interaction. Submitted