Biocenter, Area Biochemistry and Chemistry
Johann Hofmann, Ph.D.
Innsbruck Medical University, Biocenter, Medical Biochemistry, Fritz-Pregl-Str. 3, A-6020 Innsbruck
e-mail: johann.hofmann@i-med.ac.at
Phone +43-(0)512-9003-70130 Fax +43-(0)512-9003-73130
Research Areas
- Investigations into the function of unknown genes or ESTs regulated by PKCepsilon.
- Development of antagonists of PKCepsilon by interference between PKCepsilon and RACK2
- Investigations into the mechanism of action of novel bicyclic hydrazones with antitumor activity.
Ongoing Projects
- Role of PKC-epsilon modulated genes, FWF P19878
- PKCepsilon antagonist, Pro-KinaseResearch, FP6, EU
Previously completed Ph. D. or Master Theseses
- Bettina Wiesenhofer: The Role of Protein Kinase C in Tumor Therapy, 1997
- Verena Biedermann: Modulation of Protein Kinase C Activity in Cervix Carcinoma Cells, 1998
- Marcel Jenny: Effects of Novel Potential Antitumor Compounds on Human Tumor Cells, 1999
- Erika Rosivatz: The Influence of PKC epsilon on Gene Expression, 2000
- Eva Margreiter: Thiosemicarbazone-Derivatives as Potential Antitumor Drugs, 2004
- Andrea Nessler: The Influence of PKC epsilon on Gene Expression, 2004
- Astrid Wolf: Investigations into New Multidrug Resistance Reversing Compounds, 2005
- Dorota Garczarczyk: Characterization of C6orf69, a Gene Modulated by Protein Kinase C epsilon 2005
Working in the laboratory at present
- Dorata Garczarczyk
- Florian Rechfeld
- Simone Stenico
- Peter Gruber
Vorlesungen und Praktika (Lectures and Exercises)
- Biochemische Übungen für Mediziner
- Seminar für wissenschaftliches Arbeiten
- Wissenschaftliches Arbeiten für Fortgeschrittene
- Biochemisches Praktikum für Fortgeschrittene
Themen des Praktikums für Fortgeschrittene
Messung der Genexpression: Humane Zellkultur, RNA-Isolierung und Messung, Messung
der mRNA eines bestimmten Gens mittels Northern Blots, PCR und Western Blots.
Adressen für bioinformatische Anwendungen. Nach den Wünschen der Teilnehmer können
Teile weggelassen und andere zugefügt werden.
Dauer: 3 Tage.
Anmeldung mittels e-mail an johann.hofmann@i-med.ac.at